... the histaminergic and eicosanoid systems in the male rat brain interact in their regulation of ACTH secretion. The PG synthesis inhibitor indomethacin (10 mg/kg i.p.) attenuated the ACTH response to LPS (10 µg/kg i.p.) and HA (30 µg i.c.v.). Infusion of PGE 1 , PGE 2 or PGF 2α (1 and/or 5 µg infused...

... and ACTH was maximally stimulated by 2.0 ng IL-1β. Also, immunocytochemically labelled CRH in the ME was markedly depleted after intra-ME IL-1β. Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-lβ from hypothalamic explants...

... in Krebs-Ringer bicarbonate buffer, medial basal hypothalami (MBH) were preincubated for 30 min with dexamethasone (DEX), a phospholipase A 2 (PLA 2 ) inhibitor, to block arachidonic acid (AA) formation, or with inhibitors of AA metabolism: a cyclooxygenase inhibitor – indomethacin (IND); a lipoxygenase...

..., indomethacin, would have on these responses. Endotoxin caused a marked release of OXY from mean baseline levels of 5 pg/ml to mean peak levels of 168 pg/ml. Indomethacin greatly attenuated this increase. In contrast, OXY release in response to hemorrhage of either 22 or 44%of the blood volume of the rat...

..., instructions or products referred to in the content or advertisements. Prostaglandins Luteinizing hormone Prolactin Pituitary Arachidonic acid Cycloxygenase Lipoxygenase Indomethacin Nordihydroguaiaretic acid Neuroendocrinology 43: 428 434 ( 1986) © 1986 S. Karger AO, Basel 0028 3835/86/0433...

... observations, PG synthesis-inhibiting drugs, salicylate and indomethacin (INDO), reduced GH and TSH secretion. Another PG synthesis-inhibiting drug, acetaminophen, also reduced GH and TSH secretion. Antisomatostatin serum administered to INDO-treated rats indicated that somatostatin has a relatively small role...

...Joseph Weidenfeld; Richard Allen Siegel; Nissim Conforti; Israel Chowers The present study was designed to determine the role of glucocorticoids in the mediation of the stimulatory effect of indomethacin (IM) on the hypothalamo-hypophyseal-adrenal axis. Intact male rats were treated with a single...

... with indomethacin (7.6 μg/min) or vehicle, dogs were infused intravenously with either 2.5 or 0.15 M NaCl. Hypertonic saline infusion elevated plasma osmolality approximately 60 mosm/kg H2O. In accordance, the plasma ADH concentration increased substantially in animals perfused ventriculocisternally...

...J. Weidenfeld; R.A. Siegel; N. Conforti; I. Chowers The effects of the prostaglandin (PG) synthetase inhibitor indomethacin (IM) on basal and stress-induced activity of the hypothalamo-hypophyseal-adrenal (HHA) axis were investigated. IM was systemically administered to adult male rats in a single...

...E.A. Linton; G.W. Bennett; S.A. Whitehead The possible role of prostaglandins (PGs) in the hypothalamic control of ovulation has been investigated by studying the effects of indomethacin (ID) and PGs on the release of luteinizing hormone-releasing hormone (LHRH) from hypothalamic synaptosomes...

...M. Yamamoto; L. Share; R.E. Shade In anesthetized dogs, perfusion of the cerebral ventricles with indomethacin (IM), an inhibitor of prostaglandin biosynthesis, at rates of 1.9 or 7.6 µ g/min was without effect on the plasma ADH concentration. Ventriculo-cisternal perfusion with angiotensin II (All...

...M.E. Thompson; G.A. Hedge The importance of endogenous prostaglandins (PGs) in regulating CRF release was investigated by administering the PG synthesis inhibitor, indomethacin (Ind), in specific hypothalamic regions to adult female rats. Solid Ind pellets placed in the anterior hypothalamic area...