...Yuan Zhan; Lang Lang; Fen Wang; Xian Wu; Haiwang Zhang; Yuelin Dong; Hao Yang; Defa Zhu Introduction: Hypothyroidism and its induced neurological-associated disorders greatly affect the health-related quality of patients’ life. Meanwhile, microglia in brain have essential regulatory functions...

... and organs, and Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment. Hypothyroidism occurs when there is insufficient production of thyroid hormones (THs) by the thyroid. The relationship between hypothyroidism and aging as well as AD is controversial at present...

...Jiancang Cao; Chen Chen; Taotao Zhang; Yalan Han; Rui Qin; Wenxiu Su; Jing Tian; Fengli Liang; Qian Shi; Huiyan Zhang; Gang Huang; Limin Tian; Ying Wang; Lianping Zhao Introduction: Hypothyroidism leads to impaired white matter (WM) integrity, associated with cognitive/neuropsychiatric dysfunction...

...Yasser A. Khadrawy; Noha M. Khoder; Hussein G. Sawie; Hayat M. Sharada; Eman N. Hosny; Mohga S. Abdulla Objective: The present study evaluates the neuroprotective effect of α-lipoic acid (ALA) and/or metformin (MET) on the behavioral and neurochemical changes induced by hypothyroidism. Methods...

... of this disorder, one of which is endocrine disorders. Thyroid hormones are involved in various physiological processes in the body; one of the most important of them is neuromodulation. Thyroid disorders, including hyperthyroidism or hypothyroidism, can affect the nervous system and play a role in the development...

... disturbances or by selenium status. Aims: To investigate whether or not dietary diphenyl diselenide can modify the expression of genes of antioxidant enzymes and endpoint markers of oxidative stress under hypothyroid conditions. Methods: Female rats were rendered hypothyroid by continuous exposure...

...Anthony J. Cleare; Alan McGregor; Susan M. Chambers; Sheila Dawling; Veronica O’Keane Hypothyroidism is associated with both reduced central 5-HT function and an increased incidence of depression. This study tested the hypothesis that the reduced 5-HT function returns to normal with thyroxine...

...César Varela; Luanda Cacicedo; Gumersindo Fernández; Teresa de los Frailes; F. Sánchez Franco The effects of hypothyroidism duration on several factors implicated in GH secretion control were studied in the male rat at different maturity stages, ranging from the peripuberal period to adulthood...

...Daniel D. Savage; Mary Alice Otero; Christine Y. Montano; Seddigheh Razani-Boroujerdi; Linda L. Paxton; Edward J. Kasarskis The effect of perinatal hypothyroidism on hippocampal mossy fiber zinc density was examined in rats. Timed pregnant Sprague-Dawley rat dams were given water containing either...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Thyrotropin-releasing hormone Hypothalamic nuclei Messenger RNA Hypothyroidism...

...Luciana Giardino; Antonino Velardo; Andrea Gallinelli; Laura Calzà In this paper we describe the modification of the galanin (GAL)-like immunostaining in the hypothalamus of rats, which were made hypothyroid at 52 days after birth. On 21st day after the surgical ablation of the thyroid gland...

... was studied in the rat. In hypothyroid animals treated by thyroidectomy (Tx), the ME content of TRH and PYE 27 was reduced by more than 50%; further, when compared with euthyroid controls there was a significant 2-fold enhancement of the in vitro release of these peptides from ME fragments in response...

...Morteza Behnam-Rassoli; Linda C. Herbert; Vyvyan Howard; Peter O.D. Pharoah; Martin Stanisstreet The effects of a pre- and postnatal hypothyroid environment on the development of the neocortex have been determined. Rats were treated with propylthiouracil (PTU) with or without thyroid hormone...

...Daniel D. Savage; Christine Y. Montano; Alice Otero; Linda L. Paxton The effect of perinatal hypothyroidism on the number and distribution of hippocampal kainic acid binding sites was examined in rats. Timed pregnant Sprague-Dawley rat dams were given water containing either 0.02% propylthiouracil...

...Antonio Argiolas; Lugi Gessa; Rosaria Melis; Roberto Stancampiano; Andrea Vaccari Prenatal plus neonatal administration of methimazole (MMI), a procedure provoking marked hypothyroidism in rats, increased by about 100% the thymic content of oxytocin and severely (by approximately 80%) decreased...

...Karen S.L. Lam; Seymour Reichlin In this study, we demonstrated that the cell content and basal secretion of vasoactive intestinal peptide (VIP) in primary rat pituitary cell cultures were increased in hypothyroidism. VIP release from hypothyroid pituitary cells in vitro was stimulated...

... synthesis of DA in the neurons, a greater concentration of DA in hypophysial portal plasma as well as an augmented accumulation of DA in the adenohypophysis. In the same animals, PRL was reduced in the adenohypophysis and in plasma, reflecting a blunted secretion of PRL in severe hypothyroidism. Treatment...

... with chlorpromazine and antiserum against somatostatin. Chlorpromazine plus somatostatin antiserum pretreated rats gave consistent response to GRF which was not observed in untreated rats. Chlorpromazine alone has no effect on GH secretion induced by GRF in rat pituitary monolayer culture. In rats made hypothyroid...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth hormone Thyroid hormones Somatostatin GRF Hypothyroidism Neuroendocrinology 41: 476-481 (1985) © 1985 S...

...Luigi Molinengo; M. Chiara Cassone; Livio Oggero The postmortal decay of acetylcholine (Ach) was studied in the cervical spinal cords of rats in conditions of hyper- and hypothyroidism. The modifications of thyroid function were achieved either by chronic (20–25 days) administration of /-thyroxine...