... hypothalamic TRH release in medium with 56 ml KC1 increased 3-fold compared to basal release, and in these depolarization conditions TRH release was similar between hypothalami from control, starved and refed rats. In rats starved for 2 days, TRH level in hypophysial portal blood was lower than...

... (into hypophysial portal blood) and in vitro (from hypothalamic fragments) 5,9 and 30 days after induction of diabetes. Experimental diabetes was induced by an intraperitoneal injection of streptozotocin (STZ) at a dose of 65 mg/kg. Basal plasma GH was significantly reduced in diabetic rats at all stages...

... decarboxylase inhibition) and dopamine release into hypophysial portal blood, and PRL influence on the activity of the ΗDA neurons was studied after repeated s.c. administrations of ovine PRL (oPRL) or the solvent vehicle. A reduced activity of the ΗDA neurons was observed in both groups of nulliparous aged...

... secretion into hypophysial portal blood were examined in pentobarbital-anesthetized male rats. Neither the concentration of SRIF in portal plasma nor the secretion rate of SRIF was changed after i.c.v. administration of 0.9% saline. Administration of 10 ng or 5 µg human GRF i.c.v. produced a significant...

... of the tuberoinfundibular dopaminergic (TIDA) neurons was evaluated by measurement of dopamine (DA) biosynthesis in the neurons and DA release into hypophysial portal blood. The accumulation of DA and PRL in the adenohypophysis as well as PRL concentration in plasma were also estimated, and the various parameters were...

... (ACTH) secretion, we have measured CRF levels in rat hypophysial portal blood (HPB) after the pharmacological destruction of the ventral noradrenergic bundle (VNAB), using 6-hydroxydopamine (6-OHDA) stereotaxically injected into the VNAB. CRF levels in HPB were measured by radioimmunoassay...

...Iain C.A.F. Robinson; Keith M. Fairhall; Ron C. Dow; George Fink A method has been devised for collecting hypophysial portal blood from the anaesthetised guinea pig in order to measure the release in vivo of the neurohypophysial peptides, oxytocin (OT), vasopressin (AVP), neurophysin (NP...

.... This difference was due, at least in part, to an approximately twofold greater release of CRF-41 into hypophysial portal blood of the Long-Evans and Brattleboro compared with Wistar rats. There was no significant difference between the strains in the output of oxytocin into portal blood. While no AVP could...

... measured CRF secretion in hypophysial portal blood (HPB) in rats anesthetized with sodium thiopental after injection of insulin. Before treatment, systemic ACTH levels (952 ± SE 143 pg/ml; n= 12) were well above normal values, probably reflecting the anesthetic and surgical stress consecutive...

...John Sheward; Robert Benoit; George Fink Somatostatin-28(1-12)-like immunoreactivity was measured in extracts of rat hypophysial portal blood and peripherial blood. The concentration of somatostatin-28(1–12) was higher in portal than in peripheral extracts, and its release into portal vessel blood...

... in hypophysial portal blood. Vasopressin was measured by radioimmunoassay in plasma obtained by microcannulation of individual long portal veins of 8 intact male Long-Evans rats (2.0 ± 0.44 ng/ml SEM), and in 8 in which the posterior pituitary was removed just prior to collection (1.5 ± 0.3 ng/ml SEM). Since...