... can be identified intraoperatively, partial or even total hypophysectomy has been suggested. However, the outcome of these procedures is less favorable than with selective resections of distinct adenomas. Less than 10% of pituitary adenomas associated with Cushing’s disease are macroadenomas...

...] (doses/100 g BW/day). Concentrations of GAL in the hypothalamus were measured by radioimmunoassay (RIA) and GAL mRNA abundance was quantified by Northern blot (6 rats/group); 2 rats/group were used for immunohistochemistry. Hypophysectomy caused decreases of hypothalamic GAL peptide and mRNA...

... by in situ hybridization using a [ 35 S]-labelled cDNA probe encoding for POMC. Hypophysectomy performed 2 weeks previously decreased by 24% the number of silver grains/unit of surface of labelled neurons. Intracerebroventricular injection of 3 µg of PRL 4 h before sacrifice induced a significant decrease...

...Miklós Palkovits; Udo Buhner; Helmut Geiger; Mariann Fodor; August Heidland Twelve days after hypophysectomy depleted atrial natriuretic polypeptide (ANP) concentrations were measured in the plasma and in 8 of 18 microdissected brain nuclei of rats. Reduced ANP levels were found in brain structures...

... commissural, periventricular, and perifornical nuclei. In intact rats PACAP immunolabeled fibers were present in the internal zone of the median eminence and posterior pituitary. One week after hypophysectomy the intensity of staining in the internal zone was enhanced and immunoreactive fibers appeared...

... in the hypothalamus; an even more pronounced decrease was found after hypophysectomy of female animals. A treatment with estradiol restored the PRL binding in the ovariectomized rats to above normal levels. These results of in vitro biochemical analysis together with the experimental modulation of hormonal status...

..., instructions or products referred to in the content or advertisements. Benzodiazepine binding Adrenal gland Hypophysectomy Corticosterone Circadian rhythms Neuroendocrinology 199ü;51:97 103 © 1990 S. Karger AG. Basel 0028-3835/90/0511-0097 S 2.75/0 Influence of the Pituitary-Adrenal Axis...

... not change in adult rats. SS content was unchanged in either age group. Following hypophysectomy GHRH content declined similarly in both groups, whereas the decrease in SS content was greater in adolescent rats. With replacement rGH, weight gain was restored, GHRH content increased but not fully to control...

... was detected in all brain regions in both the male and the female rat brain, the concentrations of IR-PRL in the female rat were significantly greater than those measured in the corresponding region of the male rat brain. In the female rat, hypophysectomy significantly reduced, but did not eliminate...

...William J. DeVito Immunoreactive prolactin (ir-PRL) has been identified in the cerebrospinal fluid (CSF) and brain of the male and female rat. In this study we determined the concentration of ir-PRL in the CSF and hypothalamus under conditions known to increase or decrease serum PRL. Hypophysectomy...

...William C. Engeland; Donald S. Gann To test whether or not splanchnic neural input to the adrenal gland affects secretion of steroids from the adrenal cortex, the thoracic splanchnic nerve was electrically stimulated in pentobarbital-anesthetized dogs after hypophysectomy and replacement...

... for pituitary prolactin (0.71 ± 0.04 for pituitary, vs. 0.19 ±0.06 in the hypothalamus; p < 0.001). Hypophysectomy, which led to the expected fall in serum prolactin to undetectable levels, and restraint stress, which resulted in a statistically significant 4-fold rise in serum prolactin, caused no change...

... by measuring the rate of DA synthesis (DOPA accumulation after the administration of a decarboxylase inhibitor) in the median eminence at various times after serum concentrations of prolactin had been reduced by hypophysectomy or the chronic administration of a DA agonist (bromocriptine, 3 mg/kg/day...

...Mátyás Fekete; Béla Bohus; David De Wied Hypophysectomy resulted in a marked impaired acquisition of shuttle-box avoidance learning, when lower shock intensity (0.05 mA) was used as the unconditioned stimulus, but not when shock intensity was increased to 0.12 mA. Daily subcutaneous treatment...

...Dick Veldhuis; Ronald De Kloet The effect of hypophysectomy on the number of corticosterone receptor sites was investigated in three rat brain regions and was compared with the effect of long-term adrenalectomy. Subsequently, the effect on receptor capacity was measured after the hypophysectomized...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Immunoreactive brain TSH Hypophysectomy Tissue culture Neuroendocrinology 34:327-332 ( 1982) TSH in the Rat...

... of the mediobasal hypothalamus, posterolateral deafferentation, or hypophysectomy. PCA increased plasma renin activity in sham-operated rats, but it failed to increase plasma renin activity in rats with mediobasal hypothalamic lesions or posterolateral deafferentation. The response to PCA was unaffected...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hamster prolactin Pulsatile release Ether stress Hypophysectomy Photoperiod Starvation Refeeding Septal lesions Hippocampal transections Neuroendocrinology 35:13-21 (1982...

...) and thalamus (39.8 ± 13.9 ng/g). Hypophysectomy significantly reduced hypothalamic MSH content and concentration but did not alter MSH concentration in pineal and thalamus. From these results, we conclude that hypothalamic α MSH is, in part, of hypophyseal origin while pineal and thalamus «MSH does...

... in the secretion of 17-hydroxycorticosteroids (17-OHCS) by the adrenal gland. The maximum response was seen at 10 min after the injection and a return to preinjection levels tended to occur by 60 min. This effect was abolished completely by hypophysectomy. In dogs whose heads had been irradiated with 200 and 1,000...