...Mi Ae Kim; Tae Ha Kim; Priyadharshini Kannan; Kang Hee Kho; Keunwan Park; Young Chang Sohn Introduction: The proposed evolutionary origins and corresponding nomenclature of bilaterian gonadotropin-releasing hormone (GnRH)-related neuropeptides have changed tremendously with the aid of receptor...

... Congenital hypogonadotropic hypogonadism Kallmann syndrome Gonadotropin-releasing hormone Witteveen-Kolk syndrome Endocrinology Genetics Molecular biology Congenital hypogonadotropic hypogonadism (CHH) is a clinically and genetically heterogeneous disorder characterized by abnormal synthesis...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2021 Insulin-like growth factor-1 Puberty Gonadotropin-releasing hormone Neurokinin B NIH...

...: Hypogonadotropic hypogonadism (HH) is hypogonadism due to either hypothalamic or pituitary dysfunction. While gonadotropin-releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic...

... mediate positive estrogen feedback to gonadotropin-releasing hormone neurons and, thus, play a fundamental role in the mid-cycle luteinizing hormone (LH) surge. The RP3V is sexually dimorphic, and male rodents with lower KP cell numbers are unable to mount estrogen-induced LH surges. Objective: To find...

.... Exome analyses in additional 124 patients with KS/CHH probands with no additional GGS signs. Results: The proband exhibited CA, absent OBs on magnetic resonance imaging, and had CHH with unilateral cryptorchidism, consistent with KS. Pulsatile Gonadotropin-releasing hormone (GnRH) therapy normalized...

... slices were employed to ascertain the functional impact of activating NPY/AgRP neurons on gonadotropin-releasing hormone (GnRH) neurons. Results: Selective activation of NPY/AgRP neurons significantly decreased post-castration LH secretion. This was observed in males and females, as well as in prenatally...

...), blood samples were collected for measurement of pulsatile LH and corticosterone, as in Experiment 1 (Fig.  1 b). [email protected] Kisspeptin Glucocorticoid receptor Luteinizing hormone Arcuate nucleus Gonadotropin-releasing hormone National Institutes of Health (NIH...

..., this strategy also has limitations such as ectopic CRE-expression and germline recombination. Two commonly used gonadotropin-releasing hormone ( Gnrh )-driven CRE-expressing mice both target GnRH neurons. However, a direct comparison of the cells targeted and their phenotypic outcome have not yet been presented...

... reduction in spine density in gonadotropin-releasing hormone (GnRH) neurons. Neuroinflammation and subsequent decrease in GnRH neuron spine density was specific for male mice, while protection in females was independent of ovarian estrogens. Methods: To examine if neuroinflammation-induced cytokines can...

... of this anatomical site, many of which also synthesize neurokinin B (NKB), are critically involved in sex hormone signaling to gonadotropin-releasing hormone (GnRH) neurons. In recent years, the basic topography, morphology, neuropeptide content, and connectivity of human KP neurons have been investigated...

...Michelle N. Bedenbaugh; Richard B. McCosh; Justin A. Lopez; John M. Connors; Robert L. Goodman; Stanley M. Hileman Background: Neuronal intermediates that communicate estrogen and progesterone feedback to gonadotropin-releasing hormone (GnRH) neurons are essential for modulating reproductive...

... of episodic luteinizing hormone (LH) release. The resultant LH hypersecretion, likely the product of accelerated episodic release of gonadotropin-releasing hormone (GnRH) from the median eminence of the hypothalamus, hyperstimulates ovarian theca cell steroidogenesis, enabling testosterone (T...

... years. Whilst a primary testicular deficit occurs, hypothalamic or pituitary dysregulation may also coexist. This study aimed to compare the hypothalamic response to kisspeptin-54 and the pituitary response to gonadotropin-releasing hormone (GnRH) of older men with those of young men. Methods: Following...

..., instructions or products referred to in the content or advertisements. Luteinizing hormone Gonadotropin-releasing hormone Sleep Polycystic ovary syndrome National Institutes of Health (NIH) 10.13039/100000002 Progesterone is the primary hormonal regulator of day-to-day luteinizing...

...Karolina Skorupskaite; Jyothis T. George; Johannes D. Veldhuis; Robert P. Millar; Richard A. Anderson Objectives: Neurokinin B (NKB) and kisspeptin are obligate for normal gonadotropin secretion, and links between gonadotropin-releasing hormone (GnRH) pulsatility and vasomotor symptoms have been...

... both sexes [ 17,18,19 ]. Other than mutations in MKRN3 , only one other genetic defect in association with male idiopathic CPP has been reported, in a boy with a gain-of-function mutation in KISS1 [ 20 ]. Genetics Gonadotropin-releasing hormone MKRN3 gene Male precocious puberty ©...

... regulating gonadotropin-releasing hormone (GnRH) secretion, and hence gonadotropin secretion, is gradually being unraveled. This has increased our understanding of the central mechanism regulating puberty and subsequent reproductive performance in mammals. Recently, emerging evidence has indicated...

... neuroendocrine activity. Here, methods for monitoring these various parameters are briefly reviewed and then examples presented of both concordance and discrepancy between central and peripheral measurements, with a focus on situations in which elevated gonadotropin-releasing hormone neurosecretion...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gonadotropin-releasing hormone Reproduction Neuronal plasticity Cell migration Development The normal...