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Keywords: Gonadotropin-releasing hormone
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Neuroendocrinology (2021) 111 (12): 1176–1186.
Published Online: 23 November 2020
...: Hypogonadotropic hypogonadism (HH) is hypogonadism due to either hypothalamic or pituitary dysfunction. While gonadotropin-releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic...
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Neuroendocrinology (2021) 111 (3): 249–262.
Published Online: 16 April 2020
... mediate positive estrogen feedback to gonadotropin-releasing hormone neurons and, thus, play a fundamental role in the mid-cycle luteinizing hormone (LH) surge. The RP3V is sexually dimorphic, and male rodents with lower KP cell numbers are unable to mount estrogen-induced LH surges. Objective: To find...
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Neuroendocrinology (2020) 110 (7-8): 671–687.
Published Online: 21 October 2019
... slices were employed to ascertain the functional impact of activating NPY/AgRP neurons on gonadotropin-releasing hormone (GnRH) neurons. Results: Selective activation of NPY/AgRP neurons significantly decreased post-castration LH secretion. This was observed in males and females, as well as in prenatally...
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Neuroendocrinology (2019) 108 (4): 328–342.
Published Online: 10 February 2019
..., this strategy also has limitations such as ectopic CRE-expression and germline recombination. Two commonly used gonadotropin-releasing hormone ( Gnrh )-driven CRE-expressing mice both target GnRH neurons. However, a direct comparison of the cells targeted and their phenotypic outcome have not yet been presented...
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Neuroendocrinology (2019) 108 (4): 291–307.
Published Online: 10 January 2019
... reduction in spine density in gonadotropin-releasing hormone (GnRH) neurons. Neuroinflammation and subsequent decrease in GnRH neuron spine density was specific for male mice, while protection in females was independent of ovarian estrogens. Methods: To examine if neuroinflammation-induced cytokines can...
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Neuroendocrinology (2019) 109 (3): 230–241.
Published Online: 06 January 2019
... of this anatomical site, many of which also synthesize neurokinin B (NKB), are critically involved in sex hormone signaling to gonadotropin-releasing hormone (GnRH) neurons. In recent years, the basic topography, morphology, neuropeptide content, and connectivity of human KP neurons have been investigated...
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Neuroendocrinology (2016) 103 (6): 640–649.
Published Online: 11 March 2016
... regulating gonadotropin-releasing hormone (GnRH) secretion, and hence gonadotropin secretion, is gradually being unraveled. This has increased our understanding of the central mechanism regulating puberty and subsequent reproductive performance in mammals. Recently, emerging evidence has indicated...
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Neuroendocrinology (2015) 102 (4): 256–266.
Published Online: 12 August 2015
... neuroendocrine activity. Here, methods for monitoring these various parameters are briefly reviewed and then examples presented of both concordance and discrepancy between central and peripheral measurements, with a focus on situations in which elevated gonadotropin-releasing hormone neurosecretion...
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