... to increase exploratory/food-seeking behaviors while reducing avoidance behaviors. We recently reported that overnight food deprivation reduces conditioned passive avoidance behavior in male (but not female) rats. Since fasting increases circulating levels of ghrelin, we hypothesized that ghrelin signaling...

...Alexandra Labarthe; Philippe Zizzari; Oriane Fiquet; Nicolas Lebrun; Johannes D. Veldhuis; Ferdinand Roelfsema; Christophe Chauveau; Mohammad Bohlooly-Y; Jacques Epelbaum; Virginie Tolle Introduction: While the vast majority of research investigating the role of ghrelin or its receptor, GHS-R1a...

...Kristie Conde; Troy A. Roepke Obesity and anorexia result in dysregulation of the hypothalamic–pituitary–gonadal axis, negatively impacting reproduction. Ghrelin, secreted from the stomach, potentially mediates negative energy states and neuroendocrine control of reproduction by acting through...

...Dragana Miljić; Snežana Polovina; Mirjana Doknić; Sandra Pekić; Marko Stojanović; Milan Petakov; Dragan Micić; Vera Popović Background/Aims: Exaggerated adrenocorticotropic hormone (ACTH) and cortisol responses to ghrelin in Cushing's disease (CD) have previously been reported, similarly...

... be important for long-term regulation of appetite but not necessarily for the short-term feeding behavior that is elicited upon activation of AGRP neurons. Agouti-related protein Appetite Ghrelin A longstanding goal of neuroscience is to understand the relationship between brain function...

...Georgios Paslakis; Arlette F. Buchmann; Sabine Westphal; Tobias Banaschewski; Erika Hohm; Ulrich S. Zimmermann; Manfred Laucht; Michael Deuschle Background: The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion...

...Malin Grönberg; Apostolos V. Tsolakis; Ulf Holmbäck; Mats Stridsberg; Lars Grimelius; Eva T. Janson Background: Ghrelin and obestatin are derived from the same peptide hormone precursor and are mainly produced by the gastric mucosa. Ghrelin is involved in many biological processes, whereas...

... investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin. Methods: Rats were injected intracerebroventricularly with ghrelin (5 µg), metformin (50, 100 or 200 µg), 5-amino...

... in AN, the pathophysiology underlying impaired bone metabolism, and possible therapeutic strategies to optimize bone health. Anorexia nervosa Growth hormone Cortisol Gonadal steroids Ghrelin Leptin Peptide YY Adiponectin Bone density Bone turnover markers Bone microarchitecture National Institutes...

...Rie Ogata; Toshiya Matsuzaki; Takeshi Iwasa; Machiko Kiyokawa; Naoko Tanaka; Akira Kuwahara; Toshiyuki Yasui; Minoru Irahara Objectives: Ghrelin, an endogenous growth hormone secretagogue, is a known accelerator of feeding behavior and suppresses pulsatile secretion of luteinizing hormone (LH...

... body weight gain including the cannabinoid receptor 1 (CB 1 ), the serotonin receptor 2C, the ghrelin receptor, neuropeptide Y, adiponectin and proopiomelanocortin. We investigated whether the expression of these factors was affected in rats chronically treated with the antipsychotic risperidone...

...Branka Šošić-Jurjević; Darko Stevanović; Verica Milošević; Milka Sekulić; Vesna Starčević Body weight depends on the balance between energy intake and consumption. An interaction between ghrelin and thyroid function has been reported only in pathophysiological states. We examined whether...

...Yona Greenman; Vanessa Rouach; Rona Limor; Susan Gilad; Naftali Stern Background/Aims: The secretion and regulation of several hormones such as leptin and growth hormone (GH) is sexually dimorphic. Gender effects on ghrelin, a hormone involved in the regulation of GH secretion and appetite control...

...Joanne L. Harrison; David W. Miller; Patricia A. Findlay; Clare L. Adam Ghrelin is a circulating peptide, primarily secreted by the gut, that has reported actions within the hypothalamo-pituitary axis to stimulate food intake, inhibit GnRH/LH secretion and stimulate GH secretion in monogastric...

...Yuxiang Sun; Mark Asnicar; Roy G. Smith Ghrelin, an acylated 28-amino-acid peptide, is an endogenous ligand of the growth hormone secretagogue type 1a (GHS-R1a). Ghrelin is best known for its hypothalamic actions on growth hormone-releasing hormone neurons and neuropeptide Y/agouti-related peptide...

... peptide, ghrelin, has been disclosed by observations on its putative roles in the control of gonadal function and gonadotropin secretion. Of note, leptin and ghrelin have been proposed to act as reciprocal regulators of energy homeostasis. However, their potential interplay in the control of reproduction...

...Giampiero Muccioli; Alessandra Baragli; Riccarda Granata; Mauro Papotti; Ezio Ghigo Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the type 1a GH secretagogue receptor (GHS-R1a) located in the hypothalamus-pituitary axis. GHS-R1a is a G-protein-coupled...

...: The aim was to evaluateearly changes in hormones involved in neuroendocrine regulations (serum cortisol, growth hormone and prolactin) and positive energy balance (serum insulin, leptin and ghrelin) during SGA treatment in normal-weight patients with schizophrenia with the purpose of exploring...

...-activating peptide in 85% and by leptin but only in 51% of somatotropes. Ghrelin acutely increased [Ca 2+ ] i in only 21% of somatotropes. Perfusion with gonadotropin-releasing hormone elevated [Ca 2+ ] i , but in only 40% of somatotropes. The kinetics of calcium transients and the magnitude of the response...

...Saeko Akimoto-Takano; Chihiro Sakurai; Setsuko Kanai; Hiroko Hosoya; Minoru Ohta; Kyoko Miyasaka Aging is associated with a progressive decrease in appetite and food intake. The appetite-stimulating peptides orexin A, neuropeptide Y (NPY) and ghrelin are known to play a critical role in food intake...