.... a Coronal section of a rat brain demonstrating labeling associated with an antisense mRNA to the γ1-subunit of the GABAA receptor. The γ1 is preferentially expressed in the mPOA and the BnST, and thus provides demarcation of these two regions. b The AAS 17α-MeT, acting through the AR, promotes an increase...

... to the infundibular stalk. The red trace illustrates the effect of 16-min exposure to the Cl– channel blocker, R(+)-IAA-94, at 100 µM. The effect is very similar to that of the GABAA-receptor blockers, bicuculline and picrotoxin. Fig. 4 GABA A -receptor blockers modify the light scattering signal recorded...

... (a selective α-adrenergic-receptor blocker) and 2-amino-5-phosphonovaleric acid (a selective NMDA receptor antagonist), respectively. NA-induced LH release was also inhibited by i.c.v. injections of either muscimol (a selective GABAa receptor agonist) or baclofen (a selective GABAb receptor agonist...

...-Melanocyte-stimulating hormone Bruce G. Jenks Harry P. de Kouing Karine Valentijn Eric W. Roubos Department o f Animal Physiology, University of Nijmegen, The Netherlands Original Paper Neuroendocrinology 1993:58:80-85 Dual Action of GABAa Receptors on the Secretory Process of Melanotrophs of Xenopus...

... the signal by 28%. The concomitant administration of the two GABAA receptor agonists resulted in a decrease (37%) of mRNA levels which was significantly more marked than that induced by pentobarbital or muscimol alone. The present results, together with previous data, indicate that the administration...

...Michael Schumacher; Héctor Coirini; Bruce S. McEwen The regulation of 3 H-muscimol binding to high-affinity GABAa receptors by estradiol (E) and by progesterone (P) was studied within discrete brain regions using in vitro quantitative autoradiography. Treatment of ovariectomized...

... µM The effect was time dependent and reversible after drug withdrawal. Inhibition by GABA was antagonized by bicuculline (10 µM) and mimicked by the Gabaa receptor agonists muscimol and isoguvacine, but not with the GABA B agonist baclofen, indicating the involvement of GABA A receptors...