... groups, 20 and 21 brain sections from n = 6 male mice were quantified, respectively. Data are presented as mean ± SEM. For all images, scale bars correspond to 100 µm. * p < 0.05 ** p < 0.01 *** p < 0.001. ip, intraperitoneally. Hypothalamic GABA has long been known to regulate...

... to the ventral tegmental area (VTA) have not been fully investigated. Methods: Two cohorts of male and female rats received unilateral injections of the tract-tracer Fluoro-Gold (FLG) into the VTA. Immunohistochemical staining was used to quantify co-labeled FLG-positive neurons with γ-aminobutyric acid (GABA...

... postsynaptic currents (mPSCs). No GABAergic mPSCs were induced by IGF-1 in the presence of the GABA A -R blocker picrotoxin. The increase in the mPSC frequency was prevented by the use of the IGF-1R antagonist, JB1 (1 µM), or the intracellularly applied PI3K blocker (LY294002, 50 µM), showing involvement...

.... Despite continued long photoperiods, these birds eventually become refractory to the stimulating photoperiod and their reproductive systems regress. In this study, we characterized the role of γ-aminobutyric acid (GABA)ergic neurotransmission in modulating the response of the premammillary nucleus (PMM...

...Noelia P. Di Giorgio; Paolo N. Catalano; Paula V. López; Betina González; Sheila J. Semaan; Gabriela C. López; Alexander S. Kauffman; Susana B. Rulli; Gustavo M. Somoza; Bernhard Bettler; Carlos Libertun; Victoria A. Lux-Lantos Background/Aims: Adult mice lacking functional GABA B receptors (GABA...

..., Alta., Canada) into the abdominal cavity to subsequently record temporal fluctuations and cannabinoid-induced changes in core body temperature. The animals were allowed to recover for 4–6 days prior to experimentation. Cachexia Obesity GABA Glutamate CB1 receptor National Institutes...

...Shin Hyeok Kang; Jae Young Seong; Sehyung Cho; Hyeseong Cho; Kyungjin Kim Although γ-aminobutyric acid (GABA) is known to play an important role in the regulation of GnRH release from the hypothalamus, GABAergic action on hypothalamic GnRH gene expression is poorly understood. The present study...

...Hana Zemková; J. Vaněček; J. Krůšek The γ-aminobutric acid (GABA)-ergic communication between the CNS and the anterior pituitary gland has been documented in numerous histochemical and biochemical studies but electrophysiological studies characterizing the GABA A receptor in the anterior pituitary...

...Andries Kalsbeek; Willem-Jan Drijfhout; Ben H.C. Westerink; Joop J. van Heerikhuize; Tjitske P. van de Woude; Jan van der Vliet; Ruud M. Buijs Recently, anatomical evidence was presented that the mammalian circadian clock located in the suprachiasmatic nuclei (SCN) may utilize GABA to transmit...

...David R. Grattan; Michael Selmanoff We recently determined that castration specifically decreased GABA turnover in discrete rostral and mediobasal hypothalamic structures. This study aimed to investigate whether testosterone could stimulate GABAergic neuronal activity in these hypothalamic...

...Florence Rage; Catherine Rougeot; Lucia Tapia-Arancibia GABA A receptors mediate the inhibition of somatostatin gene expression and NMDA receptors mediate its stimulation. The aim of this study was to determine whether the two major neurotransmitters in the central nervous system (GABA...

...Sabine Leonhardt; Jae Young Seong; Kyungjin Kim; Yara Thorun; Wolfgang Wuttke; Hubertus Jarry γ-Aminobutyric acid (GABA) exerts an inhibitory action on gonadotropin-releasing hormone (GnRH) release from the hypothalamus. In vivo, this inhibitory action appears to be mediated via the GABA A receptor...

...Bruce G. Jenks; Harry P. de Koning; Karine Valentijn; Eric W. Roubos The effects of GABA a receptor activation on the secretion of α-melanocyte-stimulating hormone (α-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis wereexamined. The GABA a receptor agonist isoguvacine...

..., norepinephrine (NE), dopamine (DA), 5-hydroxyindoleacetic acid (5-HIAA) and γ-aminobutyric acid (GABA) from superfused hypothalamic fragments ex-planted from OVX and OVX-EB rats was determined. Two weeks after OVX, animals received EB (100 mg/kg) s.c, or oil vehicle (OVX-EB or OVX groups, respectively). Two days...

... nucleus. Estrogen treatment dramatically increased both the number of labeled cells and the intensity of immunoreaction product in these regions. In double-immunostained sections, boutons immunoreactive for antigens indicative of serotonin, pro-opiomelanocortin derived peptides, GABA, catecholamine...

... appeared to be actively secreting GABA as antagonism of GABAA receptors with bicuculline and picro-toxinin caused a dose-dependent increase in the release of immunoreactive somatostatin (SRIF), which was Ca 2+ -dependent. Although exogenous GABA inhibited SRIF secretion at concentrations of 10 –6 M...

...Olivier Kah; Vance L. Trudeau; B. Duff Sloley; John P. Chang; Pierrette Dubourg; Kei Li Yu; Richard E. Peter The influence of GABA on pituitary gonadotrophin (GTH) release in the goldfish was studied by means of in vivo and in vitro techniques. It was found that GABA injected intraperitoneally...

...Darrell W. Brann; Pedro L. Zamorano; Carla D. Putnam-Roberts; Virendra B. Mahesh Previous studies in the male rat have demonstrated that GABA acting via GABAB receptors can abolish naloxone-induced LH secretion. The purpose of the present study was to determine if an analogous situation exists...

... negative feedback regulation of the secretion of PRL from the pituitary mediated by tuberoinfundibular GABAergic neurons. Prolactin Hypothalamus Pituitary GABA Dopamine Fura-2 Calcium Feedback © 1992 S. Karger AG, Basel 1992 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

...Kazuo Otake; Kunikazu Kondo; Yutaka Oiso We examined the effects of γ-aminobutyric acid (GABA) and naloxone, a potent opioid antagonist, on arginine vasopressin (AVP) secretion in conscious rats in order to study the relationship of GABA and endogenous opioid peptides in the regulation of AVP...