.... Furthermore, we found that inhibition of hypothalamic FTO promoted STAT3-S727 phosphorylation in the hypothalamic arcuate nucleus, and the mice showed reductions in food intake and body weight. In addition, inhibition of hypothalamic ERK1/2 could abolish the effects of FTO inhibition on STAT3-S727...

... on the hypothalamus and subsequently on the food intake and obesity in females. Methods: A dihydroxy testosterone (DHT)-induced rat model was established to recapitulate the hyperandrogenism features of PCOS patients. Body weight and food intake of the rats were recorded. The food intake of DHT-induced rats...

... expression were measured at 48 h and 30 days post-rMTBI. Further, sodium butyrate (SB), a pan-histone deacetylase (HDAC) inhibitor, was administered to examine whether histone deacetylation is involved in NPY expression post-rMTBI. Results: The rMTBI attenuated food intake, which was coincident...

... mechanisms linking hypothalamic mitochondria and obesity are still to be discovered. Our previous whole-body knockout studies showed that loss of C2CD5 induced pronounced obesity by modifying food intake behavior [9]. It is clearly established that hypothalamic neurons regulate body weight homeostasis...

...-deficient Ob/Ob and calcitonin gene-related peptide (CGRP)-deficient mice. Results: We report that portal glucose infusion decreases food intake and plasma glucose and induces in the hypothalamic arcuate nucleus (ARC) the phosphorylation of STAT3, the classic intracellular messenger of leptin signaling...

... and PACAP receptor interactions. Administration of the PACAP type 1 receptor (PAC1R) antagonist, PACAP 6–38 , into the third ventricle of mice attenuates leptin-induced suppression of food intake, body weight, and changes in thermogenesis [ 21 ], further suggesting that leptin and PACAP functionally...

... regulator of food intake and energy homeostasis in the human hypothalamus. In the LHA, an appetite- and reward-related brain area, reduced NUCB2/nesfatin-1 immunoexpression may contribute to dysregulation of homeostatic and/or hedonic feeding behavior and obesity. NUCB2/nesfatin-1 localization in NBM/DBB...

... is to manage body temperature homeostasis, e.g. in response to ambient temperature change, which is achieved in part by controlling brown adipose tissue thermogenesis. The POA is also importantly involved in modulating food intake in response to temperature change, thus making it relevant for body weight...

...Chunling Yan; Yanlin He; Yuanzhong Xu; Gang Shu; Chunmei Wang; Yongjie Yang; Kenji Saito; Pingwen Xu; Antentor Othrell Hinton Jr.; Xiaofeng Yan; Likai Yu; Qi Wu; Patrick Tso; Qingchun Tong; Yong Xu Background/Aims: Apolipoprotein A-IV (apoA-IV) in the brain potently suppresses food intake. However...

... of the hypothalamus. Methods: The CNTF analogue, Axokine, was infused into the lateral ventricle of high-fat-fed mice for 1 week. Food intake, energy expenditure, body mass, glucose metabolism, and neurogenesis in the arcuate nucleus (ARC) of the hypothalamus were assessed 3 weeks after cessation of Axokine treatment...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hypothalamus Neuropeptide Y Agouti-related peptide Cocaine- and amphetamine-regulated transcript Pro-opiomelanocortin Food intake...

.... Gastrointestinal nerves Intestinal gluconeogenesis Food intake Endogenous glucose production Obesity Diabetes The worldwide increase in obesity and associated pathologies urges researchers to seek a better understanding of the mechanisms of control relating to food intake and energy homeostasis...

... investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin. Methods: Rats were injected intracerebroventricularly with ghrelin (5 µg), metformin (50, 100 or 200 µg), 5-amino...

... secretion, increases food intake (FI) and promotes body weight (BW) gain most likely via activation of the growth hormone secretagogue receptor type 1a (GHSR1a). GSK1614343 is a novel selective and potent GHSR antagonist with no partial agonist properties, recently characterized as GH secretion inhibitor...

...Dana I. Briggs; Zane B. Andrews Ghrelin plays an important role in energy metabolism by regulating food intake, body weight and glucose homeostasis. In this review, we highlight recent developments describing how ghrelin stimulates neuropeptide Y (NPY) neurons, but not pro-opiomelanocortin neurons...

... documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice ( Drd2 –/– ) puts forward new insights into the role of the D2R in growth hormone (GH)-releasing hormone-GH regulation...

...Ruth B.S. Harris Leptin acts centrally to inhibit food intake and increase energy expenditure. Corticotrophin-releasing hormone (CRH) is one of the neuropeptides that may contribute to leptin-induced hypophagia and thermogenesis. Acute leptin administration increases CRH mRNA expression...

... in the hypothalamus. We examined gene expression in the hypothalamus of genetically lean, normal and fat ewes (n = 5/group). Methods: Plasma growth hormone (GH) and metabolic indicators were measured and gene expression in brains was quantified by in situ hybridization. Results: Body weight and voluntary food intake...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Body weight Food intake Appetite Neuropeptides Neuronal...

.... Their updated orexigenic and anorexigenic effects on food intake, their signal transduction pathways from the periphery to the brain, as well as their roles in modulating gastrointestinal motility, and potential applications in the many fields of medicine such as eating disorders, obesity/anorexia-cachexia...