.... In addition, the activation of extracellular signal-regulated kinase (ERK) 1/2, one of the kinases involved in the GPER-dependent intracellular signaling pathway and in NOS phosphorylation, was assessed in the same brain nuclei. Treatment with G1 significantly decreased the number of p-ERK 1/2-positive cells...

...Margaret E. Wierman; Mei Xu; A. Pierce; B. Bliesner; S.P. Bliss; M.S. Roberson Background/Aims: Selective deletion of extracellular signal-regulated kinase (ERK) 1 and ERK2 in the pituitary gonadotrope and ovarian granulosa cells disrupts female reproductive axis function. Thus, we asked if ERK1...

... in an autocrine or paracrine manner, which is mediated by FGFRl/flg. The present study also examined gene expression of the extracellular signal-regulated kinase (ERK) family (ERK 1–3) which may be intracellular signal mediators of growth factors. ERK1 [mitogen-activated protein kinase (MAP-kinase)] was strongly...

... kinase Small G-proteins Extracellular signal-regulated kinase Protein kinase B Proliferation Apoptosis © 2007 S. Karger AG, Basel 2007 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...