...Justine Vily-Petit; Amelie Taki; Flore Sinet; Maud Soty; Bruno Guiard; Juliane Zemdegs; Gael Malleret; Anne Stefanutti; Gilles Mithieux; Amandine Gautier-Stein Introduction: Protein-enriched diets improve glycemic control in diabetes or emotional behavior in depressive patients. In mice...

...Mélodie Devère; Saloua Takhlidjt; Gaëtan Prévost; Nicolas Chartrel; Jérôme Leprince; Marie Picot Background: Obesity and type 2 diabetes are strongly associated pathologies, currently considered as a worldwide epidemic problem. Understanding the mechanisms that drive the development...

... circuit significantly decreased circulating glucose concentration. Peripheral administration of a brain impermeant muscarinic acetylcholine receptor antagonist abolished these effects. Conclusion: Disinhibiting vagal motor neurons decreases hyperglycemia in a mouse model of type 1 diabetes...

...Fang Fang; Ling Xu; Rui Zhang; Lian Liu; Min Tang; Fang Liu; Yong-De Peng; Yu-Fan Wang Introduction: Cognitive dysfunction due to reduced neuronal transmission in the brain is a major emerging complication in diabetes. However, recent neuroimaging studies have demonstrated non-linear changes...

... increase in the mean AUC values. Conclusions: Data from this in vitro study suggest that Cortexin ® has potential neuroprotective effects against chronic hyperglycemic insult in rat sensory neurons. Our results warrant further in vivo studies and may have clinical implications for diabetes-associated...

... Introduction: The aim of the study is to investigate whether acute or chronic central administration of the hypothalamic neuropeptide 26RFa may ameliorate the glycemic control of obese/diabetic mice. Methods: Mice were treated for 4 months with a high-fat (HF) diet and received a single i.c.v. injection...

...Hai Duc Nguyen; Hojin Oh; Byung Pal Yu; Ngoc Minh Hong Hoang; Won Hee Jo; Hae Young Chung; Min-Sun Kim Background: Converging evidence indicates prolactin (PRL) and diabetes play an important role in the pathophysiology of cognitive impairment. However, little is known about the mechanisms...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pancreatic neuroendocrine tumors Metabolic syndrome Diabetes Body mass index Statin...

...Claude Knauf; Anne Abot; Eve Wemelle; Patrice D. Cani The gut-brain axis is of crucial importance for controlling glucose homeostasis. Alteration of this axis promotes the type 2 diabetes (T2D) phenotype (hyperglycaemia, insulin resistance). Recently, a new concept has emerged to demonstrate...

.... Immunofluorescence was performed on the slices using the same protocol used for in vivo immunostaining. In this experiment, 6 control and 6 DIO mice were used for the pSTAT3/γ-MSH colabeling and another group of 6 control and 6 DIO mice for the pSTAT3/AgRP cola-beling. Diabetes Hypothalamus Insulin...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Leptin receptor Trafficking Cell surface receptors Biased signaling Leptin resistance Obesity Diabetes Obesity is one of the major issues of public health...

...Sheng-Feng Tsai; Hung-Tsung Wu; Pei-Chun Chen; Yun-Wen Chen; Megan Yu; Shun-Fen Tzeng; Pei-Hsuan Wu; Po-See Chen; Yu-Min Kuo Background: The notion that exposure to chronic stress predisposes individuals to developing type 2 diabetes (T2D) has gained much attention in recent decades. Long-term...

... subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial...

.... Gastrointestinal nerves Intestinal gluconeogenesis Food intake Endogenous glucose production Obesity Diabetes The worldwide increase in obesity and associated pathologies urges researchers to seek a better understanding of the mechanisms of control relating to food intake and energy homeostasis...

...Gabriella Deli; Edit Bosnyak; Gabriella Pusch; Samuel Komoly; Gergely Feher Introduction: Changes in human behaviour and lifestyle over the last century have resulted in a dramatic increase in the incidence of diabetes worldwide. Neuropathy is a common and costly complication of both type 1...

... responsible for the association because increased weight and adiposity are also seen in drug-naive individuals [ 24 ], and patients diagnosed with their first episode of psychosis were also reported to have increased frequencies of hypertension, diabetes and MetS [ 25 ]. The prevalence of MetS and its...

... gene (Adra2a) display increased insulin secretion [ 5 ], and mice with β-cell-specific overexpression of α 2A -adrenoceptors are glucose intolerant after treatment with α 2 agonist brimonidine [ 6 ]. Goto-Kakizaki (GK) rat, a model for type 2 diabetes, harbours a 1.4-Mb genomic locus linked...

...Alexis M. Stranahan; Thiruma V. Arumugam; Mark P. Mattson Background/Aims: Changes in the glucocorticoid milieu contribute to alterations in neurotropic factor expression across multiple brain regions. Insulin-resistant diabetes is often accompanied by dysregulation of adrenal steroid production...

...Alia Munir; John Newell-Price Active Cushing’s syndrome is associated with insulin resistance induced by the high and prolonged circulating level of glucocorticoids. In endogenous Cushing’s syndrome the overall incidence of diabetes mellitus and insulin resistance is very likely to be under...

...Jyothis T. George; Robert P. Millar; Richard A. Anderson Hypogonadism occurs commonly in men with type 2 diabetes (T2DM) and severe obesity. Current evidence points to a decreased secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus and thereby decreased secretion...