... under normal and pathological conditions. This review focuses on KISS1R recruitment of intracellular signaling (Gα q/11 - and β-arrestin-dependent) pathways that mediate GnRH secretion and the respective roles of rapid desensitization, internalization, and recycling of resensitized receptors...

..., instructions or products referred to in the content or advertisements. Kisspeptin KISS1R Kisspeptin analog Testosterone Desensitization Both peptide and small-molecule approaches have been studied. Kuohung et al. [ 32 ] established a high-throughput screening system to evaluate both small...

..., a desensitizing effect to long-term repetitive GHRH pulses was observed in both fetuses and neonates, but this effect was delayed in neonates. Thus, the capacity of somatotrope cells to maintain GH response to GHRH seems to be developmentally regulated during perinatal stages. Furthermore, the frequency of GHRH...

...Magdolna Kovács; András Fáncsik; Imre Mezõ; István Teplán; Béla Flerkó We examined the desensitization and/or sensitization phenomenon in the pituitary GH responsiveness induced by continuous infusion and multiple pulses at different frequencies of a potent GH-RH analog [D-Ala 2 , Leu 15 , Nle 27...

... hormone responses to the second and third stimulations at these higher dosages. These results indicate that NPY acts at the pituitary level to stimulate GH and GTH secretion in female goldfish. The GTH response and, to a lesser extent, the GH response become desensitized to further stimulation by NPY...

... of attenuation was similar in the presence or absence of SRIH, suggesting that pool depletion plays little role in the desensitization process under these experimental conditions. The results are consistent with the hypothesis that a short-term infusion of GHRH leads to attenuation of the GH response in rat...

... on LH pulse frequency and/or amplitude; (2) whether central nervous system desensitization occurred in response to the inhibitory effects of continuous NE infusion on pulsatile LH secretion, and (3) whether dopamine of serotonin were involved as possible interneuronal transmitter mediators of NE-induced...

..., vasopressin failed to influence the stimulation of adenylate cyclase activity induced by oCRF. Preincubation of anterior pituitary segments with oCRF desensitized the corticotropin (ACTH) response to oCRF and decreased the amount of 125 I-oCRF bound to membranes prepared from similarly treated pituitaries...

... infusion with 18 or 22 μg NE/h increased LH secretion, blood LH levels being elevated for the initial 40–60 min of infusion. By 60–80 min, however, blood LH levels had returned to preinfusion values and remained there for 2 h despite continuous NE infusion. This rapid desensitization of the LH secretory...