... the maladaptive changes caused by 14-week (14wk) and 20-week (20wk) CSI. Methods: We investigated the impacts of 14wk and 20wk CSI on anxiety-/depression-like behaviors in male C57BL/6N mice with classical behavioral tests, and the immunofluorescence (IF) method was used for quantification of the arginine...

...Justine Vily-Petit; Amelie Taki; Flore Sinet; Maud Soty; Bruno Guiard; Juliane Zemdegs; Gael Malleret; Anne Stefanutti; Gilles Mithieux; Amandine Gautier-Stein Introduction: Protein-enriched diets improve glycemic control in diabetes or emotional behavior in depressive patients. In mice...

...Jacqueline Kiewa; Sally Mortlock; Samantha Meltzer-Brody; Christel Middeldorp; Naomi R. Wray; Enda M. Byrne Introduction: Sex steroid hormone fluctuations may underlie both reproductive disorders and sex differences in lifetime depression prevalence. Previous studies report high comorbidity among...

...Jing Tian; Rui-Fang Liu; Zhou-Le Li; Jian Tan; Ya-Shan Lu; Wen-Wen Zhang; Ju-Xiang Liu; Rui Gong; Jian-Cang Cao; Chen Yang; Gang Huang; Ying Wang; Lian-Ping Zhao Introduction: Type 2 diabetes mellitus (T2DM) patients with depression have a higher risk of complications and mortality than T2DM...

... was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course of clinical depression with the assumption that aldosterone is a state marker of depression. Methods: A total of 78 adult subjects (39 patients with depressive disorder and 39 healthy...

... implications. The mesocorticolimbic system plays important roles in emotional and cognitive functions of the human and rodent brains. Disturbances in this system are associated with drug abuses, depression, and autism [ 10, 11 ]. While the mesolimbic system is involved in reward processes...

.... EPM and HB tests were performed on the 7th and 14th day of SCUMS exposure to test anxiety states, and at the end of this period all animal groups were subjected to FST in order to determine the depression state. Testing sessions were conducted between 02: 00 and 06: 00 p.m. in a sound-attenuated room...

...) and 344 (24–7,470) nmol/L, respectively. Overall, HRQoL was significantly impaired in patients compared to controls (15D score 0.864 ± 0.105 vs. 0.905 ± 0.028, p < 0.001). SI-NET patients scored worse on 9 of 15 dimensions: sleep, excretion (i.e., bladder and bowel function), depression, distress...

... and physical alterations and (b) healthy controls. We further evaluated body image in relation to objective acromegalic changes as judged by medical experts and psychiatric pathology, e.g. depression and cognitive impairment. Results: Patients with acromegaly did not lack subjective perception of the disease...

... mood and symptom checklist (Patient Health Questionnaire-15 [PHQ-15], Generalized Anxiety Disorder-7 [GAD-7], Patient Health Questionnaire-9 [PHQ-9]) and with questionnaires assessing general well-being (RAND 36-Item Health Survey [RAND-36]), mood (Hospital Anxiety and Depression Scale [HADS...

...Man K. Chan; Jason D. Cooper; Mariska Bot; Johann Steiner; Brenda W.J.H. Penninx; Sabine Bahn Background/Aims: Less than half of depression patients are correctly diagnosed within the primary care setting. Previous proteomic studies have identified numerous immune and neuroendocrine changes...

... study group Background: Subclinical hypothyroidism has been associated with depressive symptoms in cross-sectional studies, but prospective data and data on subclinical hyperthyroidism are scarce. Methods: In the Leiden substudy of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER...

...Michael Deuschle; Maria Gilles Background: Activation of the hypothalamic-pituitary-adrenal (HPA) system in depressed patients has been related to visceral adiposity. In contrast, low HPA system activity is associated with increased body fat in the general population. Our study intended to clarify...

...Monika Milian; Juergen Honegger; Christine Gerlach; Xenia Hemeling; Tsambika Psaras Background: Female Cushing's disease (CD) patients with active disease present more frequently with depression compared to their male co-sufferers. This study investigated whether the gender difference prevails...

...Jan Detka; Anna Kurek; Agnieszka Basta-Kaim; Marta Kubera; Władysław Lasoń; Bogusława Budziszewska Introduction: Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases...

... of the assessments (0 = parents did not smoke, 1 = at least one parent smoked until the offspring's age of 15 years). Cigarette smoke Depression Energy metabolism Epigenetics Ghrelin Intrauterine exposure Nicotine The gut-derived peptide hormone ghrelin stimulates appetite by providing signals...

... Depression Responder rate Remission Patients with Cushing's disease (CD) suffer from a considerable impairment in their health-related quality of life (HRQoL) that is by far more severe compared to patients with other clinical pictures caused by pituitary adenomas [ 1 ]. The patients do not only...

... including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological...

...Caitlin S. Wyrwoll; Megan C. Holmes Fetal glucocorticoid exposure is a key mechanism proposed to underlie prenatal ‘programming’ of adult affective behaviours such as depression and anxiety. Indeed, the glucocorticoid metabolising enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which...

.... Antidepressant Serotonin Plasticity Depression Stress Hippocampus Pregnancy and the postpartum period are accompanied by distinct neural, hormonal and behavioral plasticity in the mother [ 1 ]. Unfortunately, this is also a time when a woman is vulnerable to the effects of stress and stress-related...