... achieved areas under the receiver operating characteristic curve of 0.9647 (Cushing’s syndrome) and 0.9556 (acromegaly), accuracies of 0.9593 (Cushing’s syndrome) and 0.9479 (acromegaly), and recalls of 0.7593 (Cushing’s syndrome) and 0.8089 (acromegaly). It performed better than any level of our endocrine...

...Mesut Savas; Vincent L. Wester; Yolanda B. de Rijke; German Rubinstein; Stephanie Zopp; Kristien Dorst; Sjoerd A.A. van den Berg; Felix Beuschlein; Richard A. Feelders; Martin Reincke; Elisabeth F.C. van Rossum Background/Aims: The current diagnostic workup of Cushing’s syndrome (CS) requires...

...Dinu S. Chandran; Naseer Ali; Ashok Kumar Jaryal; Viveka P. Jyotsna; Kishore Kumar Deepak Background/Aims: Endogenous Cushing's syndrome is associated with a higher risk of cardiovascular morbidity and mortality. Previous literature suggested multiple possible links by which hypercortisolism may...

...Elena Valassi; Beverly M.K. Biller; Anne Klibanski; Madhusmita Misra Cushing’s syndrome (CS) is associated with increased cardiovascular morbidity and mortality. Recent evidence also suggests that increased cardiovascular risk may persist even after long-term remission of CS. Increased central...

...Viviana Daidone; Marco Boscaro; Elena Pontara; Maria Grazia Cattini; Gianluca Occhi; Carla Scaroni; Franco Mantero; Alessandra Casonato Background: Hypercoagulability and a tendency for thromboembolic complications are reported in Cushing’s syndrome (CS). The hypercoagulability is due mainly...

...Maria Yaneva; Silvia Vandeva; Sabina Zacharieva; Adrian F. Daly; Albert Beckers Cushing’s syndrome (CS) is characterized by pathologically elevated free glucocorticoid levels. Endogenous hypercortisolism is usually due to ACTH-secreting pituitary corticotropic adenomas and less often due to ectopic...

...Richard A. Feelders; Leo J. Hofland; Wouter W. de Herder Cushing’s syndrome is associated with serious morbidity and increased mortality. Irrespective of its cause, i.e. a pituitary adenoma, ectopic ACTH production or an adrenal neoplasia, Cushing’s syndrome is primarily treated surgically. However...

...Charlotte Steffensen; Ann Mosegaard Bak; Kristine Zøylner Rubeck; Jens Otto Lunde Jørgensen Overt Cushing’s syndrome is a rare disorder with an annual incidence of 2–3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high...

...Gregory Kaltsas; Polyzois Makras Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing’s syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone...

... to population and ethnic group. Cushing’s syndrome (CS) represents an archetype of MetS. High glucocorticoid levels lead to muscle, liver and adipocyte insulin resistance. Almost all patients with CS are obese or overweight, and have abdominal visceral adiposity. Many also have glucose metabolism abnormalities...

...Monica De Leo; Rosario Pivonello; Renata S. Auriemma; Alessia Cozzolino; Pasquale Vitale; Chiara Simeoli; Maria Cristina De Martino; Gaetano Lombardi; Annamaria Colao Cushing’s syndrome (CS) causes metabolic abnormalities that determine an increased cardiovascular risk not only during the active...

...Maria Verena Cicala; Franco Mantero Hypertension is one of the most distinguishing features of endogenous Cushing’s syndrome (CS), as it is present in about 80% of adult patients whereas in children its prevalence is about 47%. Hypertension in CS is significantly correlated with the duration...

...Krystallenia I. Alexandraki; Ashley B. Grossman Cushing’s syndrome (CS) results from sustained pathologic hypercortisolism. Increased identification of cyclical CS and the similarities between the metabolic syndrome and mild CS has resulted in an increased prevalence of CS, necessitating more...

...Mara Boschetti; Federico Gatto; Marica Arvigo; Daniela Esposito; Alberto Rebora; Miryam Talco; Manuela Albertelli; Elena Nazzari; Umberto Goglia; Francesco Minuto; Diego Ferone The recent depiction of dopamine receptors (DRs) in tumors that cause Cushing’s syndrome (CS) has renewed the debate about...

...Alberto M. Pereira; Jitske Tiemensma; Johannes A. Romijn Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients with active Cushing’s syndrome (CS) are exposed to excessive endogenous glucocorticoid levels. In these patients, psychopathology is often being...

...Laura Trementino; Giorgio Arnaldi; Gloria Appolloni; Viviana Daidone; Carla Scaroni; Alessandra Casonato; Marco Boscaro A hypercoagulable state and its consequent increased incidence of thromboembolic complications are reported in patients with Cushing’s syndrome (CS). These alterations are related...

..., instructions or products referred to in the content or advertisements. Stress Corticotropin-releasing hormone Corticotropin-releasing hormone receptors Hypothalamic-pituitary-adrenal axis Autoimmune diseases Cushing’s syndrome Nelson’s syndrome Inflammation Psychosomatic disorders Neuroimmune...

...Marco Boscaro; Annalisa Rampazzo; Agostino Paoletta; Paola Roseano; Uberto Pagotto; Francesco Fallo; Nicoletta Sonino Bilateral simultaneous inferior petrosal sinus sampling, associated with the oCRH stimulation test (100 µg i.v. as a bolus) was performed in 22 patients with Cushing’s syndrome...

... values detected at 04:00–08:00 h and 23:00–24:00 h, respectively. In patients suffering from Cushing’s syndrome, the circadian rhythm of plasma cortisol either disappeared or was inverted while that of GR did not significantly deviate from the normal subjects. For apoplexic patients with lesions...

..., growth-hormone-releasing hormone (GHRH) tests were performed in 6 nonobese Cushing’s syndrome patients and 6 controls. The normal GHRH-induced GH secretion was completely abolished in the Cushing’s syndrome group. To study the action of shorter corticoid exposures, 34 volunteers were subjected to four...