... littermates, were randomly assigned to a diet condition (low-fat, high-fat, high-fat with EPA) and followed from 2 to 10 months of age. We assessed baseline corticosterone concentration during aging, pain tolerance, cognitive function, stress coping, and corticosterone response to a stressor. Results...

... GPER Neuronal nitric oxide synthase Glutamate decarboxylase65/67 AMPK Glycogen Corticosterone NIH The ventromedial hypothalamic nucleus (VMN) is a key element of the sex-dimorphic neural network, one of several interconnected, estrogen receptor (ER)-abundant structures...

... on hippocampal clock gene expression, the SCN was lesioned, adrenal glands removed and a 24 h exogenous corticosterone rhythm at physiological levels was reestablished by use of a programmable infusion pump. Results: Daily rhythms were detected for Per1 , Per2 , Bmal1 , Nr1d1 , and Dbp, while clock gene products...

... in the locus coeruleus (LC) using immunohistochemistry. Control groups were not stressed nor received hormone therapy. Results: While basal corticosterone levels were similar between VCD-periestropausal and control rats, the secretion in response to stress in the VCD group was lower. This effect was prevented...

... here applied a novel methodology by combining the electrolytic lesion of the SCN with implantation of a micropump programmed to release corticosterone in a circadian manner mimicking the endogenous hormone profile. By use of this approach, we were able to restore the corticosterone rhythm in SCN...

... of the hypothalamus (SON). The aim of the study was to evaluate the role of SON on autonomic (mean arterial pressure [MAP], heart rate [HR], and tail temperature), neuroendocrine (corticosterone, oxytocin, and vasopressin plasma levels), and behavioral responses to RS. Methods: Guide cannulas were implanted...

... were treated with a control or low-TRP-containing diet for various time periods up to 21 days. The results show that aldosterone secretion increased after 4 days of TRP depletion and prior to corticosterone. Optimal effects of TRP depletion occurred at 14 days. In addition to neurochemical...

.... The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, insulin, insulin receptors or corticosterone concentrations in the hippocampus and frontal cortex in a prenatal stress rat model of depression. Methods: Male rats whose mothers had...

... has addressed whether the presence or absence of paternal care alters levels of hippocampal glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF), and basal levels of serum corticosterone (CORT) and adrenocorticotropin (ACTH). Here, we explored this concept using socially...

... to their behaviors during social confrontation. Antalarmin treatment was given for 4 and 6 days. The results corroborated previous data indicating that subjects who adopted a passive coping strategy had higher corticosterone levels after 21 days of defeat and decreased resting levels 3 days later. Moreover...

... and female animals. By contrast, antagonist treatment to block MR (RU-28318) or GR (Mifepristone, RU-486) prevented motor impairments caused by acute restraint stress or corticosterone treatment. Moreover, both antagonists reversed chronic stress- and glucocorticoid-induced motor impairments to values...

... exposure were used to study the plasma levels of NPY and corticosterone in stress, and brown adipose tissue thermogenic activity was measured with [ 3 H]GDP binding after cold. Results: Here, we demonstrate that sympathoadrenal activity is enhanced in the OE-NPY DBH mice. Blood pressure during surgical...

...Maryam Moosavi; Nader Maghsoudi; Saleh Zahedi-Asl; Nasser Naghdi; Mitra Yousefpour; Ian Andrew Trounce Corticosterone induces neuroanatomical and neurochemical changes in the hippocampus that are associated with cognitive impairments. In the present study corticosterone induced cell death...

... suggested that GC exert an inhibitory role in the hypothalamus surpassing the GC-positive effect at the somatotrope level. To test the hypothesis that GC can affect growth hormone-releasing factor (GRF) and somatostatin (SS) at the hypothalamic level, we studied the effect of corticosterone...

...Marc Rey; Edmond Carlier; Mustapha Talmi; Bernard Soumireu-Mourat Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we...

... from this clone each hybridized to a major 2.9-kb transcript in poly(A)-containing RNA. GPDH mRNA increased up to 10-fold in a dose-dependent manner in response to acute corticosterone (CORT) treatment (8 h-3 days) of adrenalectomized (ADX) rats. Hybrid-selected GPDH mRNA encodes a 35-kD, pI 6.3...

... basal corticosterone but not adrenocorticotropin (ACTH) levels in SHAM rats. As expected, ADX increased ACTH levels in all conditions. In response to the novel acute stressor (shock), ACTH levels were drastically dependent on the presence of corticosterone: thus, whereas in SHAM rats chronic IMO reduced...

... groups) or sham injection (control groups). After treatment, animals were tested in a transparent open field for either 30 or 60 min and thereafter sacrificed by decapitation. Plasma was collected for adrenocorticotropic hormone (ACTH), corticosterone, β-endorphin (β-EP) and interleukin-6 (IL-6...

...-pituitary-adrenocortical axis system. The hypothalamo-pituitary-adrenocortical axis in the aged rat is characterized by an increase in the basal level of circulating corticosterone, an impaired ability to recover from the adrenocortical stress response, and a reduced sensitivity to the dexamethasone...

... cultures derived from E18 fetal rats. A 24-hour pretreatment with corticosterone (CORT), the principal GC in the rat, enhanced both hypoxic and hypoglycemic cell damage, as measured by lactate dehydrogenase assay. This damaging effect was abolished when CORT exposure was reduced to 8 or 4 h prior...