... (dissociation konstant) of HA was estimated to approximately 30 µg. ICV infusion of HA (30 µg) as well as 5 min of restraint stress increased plasma renin activity (PRA) 2- and 3-fold, respectively (p < 0.01). These effects were abolished by prior ICV infusion of the H 2 -receptor antagonists cimetidine (100...

... (p < 0.05), but had no effect on basal LH secretion. The enhancement of LRH-stimulated LH secretion was not observed when either an H1- (mepyramine) or an H2- (cimetidine) receptor antagonist was administered concomitantly with HA. Cimetidine administered alone had no effect on basal or LRH...

...Valeria Sibilia; Carmela Netti; Francesca Guidobono; Francesca Pagani; Antonio Pecile The mechanism of cimetidine-induced prolactin (PRL) release was studied. Intracarotid (i.a.) administration of 1 mg/kg of impromidine, the most specific H 2 histamine agonist known, did not counteract...

...Mauro Iodice; Gaetano Lombardi; Antonio Tommaselli; Riccardo Rossi; Lucio Annunziato; Marco Minozzi The effect of acute injection of cimetidine, a selective histamine-2 receptor blocker, on prolactin (PRL) secretion was investigated in subjects with physiological puerperal hyperprolactinemia...