..., treatment side effects, and emotional and functional well-being of patients with carcinoid syndrome (CS). Methods: The development of the Functional Assessment of Cancer Therapy-Carcinoid Syndrome Symptom Index (FACT-CSI) followed US Food and Drug Administration guidelines for the development of patient...

... in combination with somatostatin analogs (SSAs) to treat carcinoid syndrome (CS) diarrhea uncontrolled by SSAs alone in adults, but long-term safety and efficacy data beyond 48 weeks are needed. Objectives: The aims of the study were to evaluate the long-term safety and tolerability of telotristat ethyl and its...

... symptom relief for patients with carcinoid syndrome and is also able to reach partial response in a significant proportion of patients and a reasonable PFS. Quality of studies was limited, highlighting the need of further prospective studies to confirm the most suitable form of liver embolisation in NENs...

...Amy Buchanan-Hughes; Alex Pashley; Marion Feuilly; Florence Marteau; D. Mark Pritchard; Simron Singh Background: Carcinoid heart disease (CHD) can develop in patients with carcinoid syndrome (CS), itself caused by overproduction of hormones and other products from some neuroendocrine tumours...

... records with the diagnosis of SI-NET or carcinoid syndrome (ICD-codes E17.9 or E34.0). Thirty subjects were excluded from the study. Of those, 10 had another severe disease (cognitive impairment, severe heart failure due to a cause other than carcinoid heart, other malignancy) and 2 were in palliative...

... neuroendocrine tumors (NETs) with characteristic radiological appearance. Its etiology is poorly understood as it affects some but not all midgut NET patients with lymphatic involvement. This study assessed a potential relationship of MF with carcinoid syndrome, urinary 5-hydroxyindoleacetic acid (5-HIAA...

... participants Neuroendocrine tumors of the small intestine are the most common causes of the carcinoid syndrome. Carcinoid heart disease occurs in more than half of the patients with the carcinoid syndrome. Patients with carcinoid heart disease who need to undergo surgery should also undergo preoperative...

... approximately 21% of all carcinoids. They are often associated with the so-called carcinoid syndrome characterized by flushing, diarrhea, wheezing, and right-sided heart pathology, being caused by the overproduction of specific hormones such as serotonin and tachykinins [ 6 ]. During the last 20 years, many...

... patients with the carcinoid syndrome and metastasized midgut carcinoid tumors underwent functional dynamic multi-phase gadolinium-enhanced MRI of selected liver metastases at baseline and 60 min after the subcutaneous (s.c.) administration of 100 µg octreotide, and also after 3 months with three times...

...; Ashley Grossman; Philippe Rougier; Wolfgang Schmidt; Bertram Wiedenmann This 6-month, open, non-controlled, multicenter, dose-titration study evaluated the efficacy and safety of 28-day prolonged-release (PR) lanreotide in the treatment of carcinoid syndrome. Eligible patients had a carcinoid tumor...

...Anouk N.A. van der Horst-Schrivers; A.N. Machteld Wymenga; Thera P. Links; Pax H.B. Willemse; Ido P. Kema; Elisabeth G.E. de Vries The carcinoid syndrome, associated with carcinoid tumors of the midgut, consists of symptoms such as diarrhea, flushing, wheezing and cardiovascular symptoms...