... of both brain cannabinoid receptors (CB-1) and anandamide, their proposed endogenous ligand, has renewed the interest in cannabinoid actions in the brain. However, the neurobiological mechanisms underlying the neuroendocrine effects of natural cannabinoids are not yet fully understood because of several...

...Joseph Weidenfeld; Shaul Feldman; Raphael Mechoulam Anandamide (arachidonylethanolamide), an endogenous ligand of the cannabinoid receptor, was recently isolated from porcine brain. We report here for the first time on the effect of this ligand on the hypothalamopituitary adrenal (HPA) axis...

... Inhibitory Effect on Prolactin Secretion by Rostral Deafferentation of the Medial Basal Hypothalamus1 Lee Tyrey Departments of Obstetrics and Gynecology and Anatomy, Duke University Medical Center, Durham. N.C., USA Key Words. Hypothalamic deafferentation Cannabinoids A^-Tetrahydrocannabinol Prolactin...

...Tibor Wenger; Catherine Ledent; Gérard Tramu The purpose of this study was to investigate the effects of the endogenous cannabinoid arachidonoyl-ethanolamide, anandamide (AEA), on the activity of the hypothalamo-pituitary-adrenal (HPA) axis in cannabinoid receptor (CB 1 receptor) inactivated (KO...

...Sara González; Jorge Manzanares; Fernando Berrendero; Tibor Wenger; Javier Corchero; Tiziana Bisogno; Julián Romero; José A. Fuentes; Vincenzo Di Marzo; José A. Ramos; Javier Fernández-Ruiz Most data on effects of natural and synthetic cannabinoids on anterior pituitary hormone secretion point out...