... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2019 Fast feedback Adrenocorticotropic hormone Cortisol CRH HPA axis Human...

... the validity of generalizing from animal models to the conditions experienced in humans [ 10 ]. The ‘fight or flight’ stress system is altered during human pregnancy with the growth and development of the placenta. The placenta expresses the genes for CRH (hCRHmRNA) and proopiomelanocortin, the precursor...

... hormone (CRH) when the patients had been on IFN-α treatment for 3 weeks. To determine the exact locus of the IFN-α action, in vitro experiments were performed using rat hypothalamic organ and primary pituitary and adrenal cell culture systems. Thereby a significant stimulation of hypothalamic CRH...

... was designed to test, using in vitro paradigms, whether there exists a hypothalamic and/or a median eminence site of action, whereby different substances derived from the immune system could stimulate the CRH and/or the arginine-vasopressin (AVP) neuronal pathway. For this purpose, whole medial basal...

...Linghe Pan; François Gilbert Previous studies have shown that activation of the 5-HT 1A receptor subtype enhances rat plasma ACTH concentration. Such receptors have been suggested to be located on CRH neuronal cell bodies in the paraventricular nuclei of the hypothalamus (PVN). In this report...

...Mark H. Whitnall A functional ultrastructural assay was used to determine the response of corticotropin releasing hormone (CRH) neurosecretory cells to short-term stress. Depletion of neurosecretory vesicles from axonal swellings in the external zone of the rat median eminence was used as a measure...