...Paola Casolini; Francesca R. Patacchioli; Rosaria Domenici; Luciano Angelucci We examined whether a different maternal genotype might differentially affect the brain adrenocorticoid receptor in homozygous diabetes insipidus Brattleboro rats. Two distinct homozygous diabetic offsprings were studied...

... concentration of vasopressin alone. Anterior pituitaries from vasopressin-deficient Brattleboro rats also show a phosphatidylinositol response to vasopressin. Pituitaries from rats that had been adrenalectomized 4 days earlier showed no increase in inositol phosphate accumulation in response to vasopressin...

...Scott Young, III; Marjorie Warden; Éva Mezey In situ hybridization histochemistry was used to locate cells containing tyrosine hydroxylase (TH) mRNA in the hypothalami of salt-loaded and Brattleboro rats. The hyperosmotic plasma conditions found in these animals, as compared to control animals...

...Michael R. Dashwood; Iain C.A.F. Robinson Specific binding sites for vasopressin (AVP) were compared in the kidney and posterior pituitary gland from normal and homozygous Brattleboro rats using autoradiography with [ 3 H]-AVP. The specificity of ligand binding was assessed by displacement with AVP...

...Lesley A. Tannahill; Ron C. Dow; Keith M. Fairhall; Iain C.A.F. Robinson; George Fink The purpose of this study was to compare the control of adrenocorticotropin (ACTH) and corticosterone secretion in homozygous Brattleboro rats with their syngeneic controls, Long-Evans rats, and with rats...

...József Zoltán Kiss; Éva Mezey Tyrosine hydroxylase (TH) immunoreactivity is present in a few magnocellular neurons in the supraoptic and paraventricular nuclei of normal Sprague-Dawley and heterozygous Brattleboro rats. Manipulations commonly used to enhance immunostaining of cell bodies...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Brattleboro rat Diabetes insipidus Roman high avoidance rat Roman high avoidance/ diabetes insipidus rat Vasopressin Vasopressin deficiency 6 02 1985 25 01...

...Joseph T. McCabe; Joan I. Morrell; Richard Ivell; Hartwig Schmale; Dietmar Richter; Donald W. Pfaff In situ hybridization has been used to identify specific hypothalamic magnocellular neurons, in normal and Brattleboro rats, that contain vasopressin (VP) or oxytocin (OT) mRNA. The subnuclear...

... gland Brattleboro rat Radioimmunoassay High-performance liquid chromatography Immunocytochemistry Cell culture Neuroendocrinology 43: 577 583 (1986) © 1986 S. Karger AG. Basel 0028 -3835/86/0435-0577 $ 2.75/0 Anterior Pituitary Cells from Brattleboro (di/di), Long-Evans and Sprague-Dawley Rats...

...F. Dreyfuss; A. Burlet; M.C. Tonon; H. Vaudry Comparative ultrastructural localization of corticotropin-releasing factor (CRF) and oxytocin was performec; in the rat median eminence of Long Evans and Brattleboro rats. The peroxidase-antiperoxidase technique used on seria. ultrathin sections...

...Ross G. Clark; Peter M. Jones; Iain C.A.F. Robinson The antidiuretic effects of intravenous (i.v.) and intracerebroventricular (i.c.v.) infusions of vasopressin (AVP) were compared in chronically cannulated conscious Brattleboro rats. AVP infused i.c.v. for 6 h reduced urine volume and increased...

... we have previously demonstrated to be required together for full activity. Most of the CRF activity of Brattleboro rat ME extract, which contains as much CRF activity as the ME extract of a normal rat, does not bind to a neurophysin affinity column. The CRF activity of Brattleboro rat ME extract...

... homozygous Brattleboro rats with diabetes insipidus (HODI) which lack VPNP, and (2) application of an antiserum to both rat neurophysins absorbed with HODI rat hypothalamic-pituitary extracts which contain only OTNP. The latter would result in an antiserum specific for VPNP. Our results indicate...

...M. Kathleen Wiley; A. Frances Pearlmutter; R.E. Miller We examined the role of vasopressin (VP) in brain-adrenal function by comparing the plasma corticosterone concentrations of rats genetically deficient in VP [Brattleboro rats, homozygous for diabetes insipidus (Dl-homo)] with those of control...

... and pineal glands from homozygous Brattleboro rats (rats with hereditary hypothalamic diabetes insipidus) revealed the total absence of AVP and AVT. We conclude that the Brattleboro rat is incapable of synthesizing biologically active neurohypophyseal peptides which contain arginine in position 8...