... are characterized by different alterations in the hypothalamus and pituitary and respond differently to different treatments, which correspond to the complex pathogenesis of patients with PCOS. Key Messages: Arcuate nucleus (ARC) is associated with luteinizing hormone (LH) surges. Suprachiasmatic nucleus, ARC...

...Nagalakshmi Balasubramanian; Sneha Sagarkar; Meha Jadhav; Navneet Shahi; Richa Sirmaur; Amul J. Sakharkar Introduction: Repeated traumatic events result in long-lasting neuropsychiatric ailments, including neuroendocrine imbalances. Neuropeptide Y (NPY) in the arcuate nucleus (Arc) is an important...

... hypothalamus. Methods: GPER immunoreactivity was assessed in different anatomical subdivisions of five selected hypothalamic regions of young adult male and cycling female rats: the arcuate nucleus, the lateral hypothalamus, the paraventricular nucleus, the supraoptic nucleus, and the ventromedial hypothalamic...

... ER signaling in an ER antagonist-sensitive manner. Importantly, the PACAP-induced excitation of POMC neurons was notably reduced in obese, high-fat (HFD)-fed males. In vivo experiments revealed that intra-arcuate nucleus (ARC) PACAP as well as chemogenetic and optogenetic stimulation of ventromedial...

...Doyeon Kim; Sangwon Jang; Jeongah Kim; Inah Park; Kyojin Ku; Mijung Choi; Sukwon Lee; Won Do Heo; Gi Hoon Son; Han Kyoung Choe; Kyungjin Kim Introduction: Synchronous and pulsatile neural activation of kisspeptin neurons in the arcuate nucleus (ARN) are important components of the gonadotropin...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Estrogen receptor α Arcuate nucleus M-current Electrophysiology Ghrelin Growth hormone secretagogue receptor National Institutes...

.... Kisspeptin Glucocorticoid receptor Luteinizing hormone Arcuate nucleus Gonadotropin-releasing hormone National Institutes of Health (NIH) 10.13039/100000002 Stress profoundly alters the physiologic function through activation of a host of chemical and hormonal pathways, including...

...). In the present study, we investigated the impact of MT1 receptor deficiency on feeding behavior, locomotor activity and mRNA expression levels encoding for the polypeptide pro-opiomelanocortin (Pomc) and neuropeptide Y (Npy) in the hypothalamic arcuate nucleus (ARC) and the adenohypophysis [pars distalis (PD...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. apoA-IV Agouti-related peptide Pro-opiomelanocortin Arcuate nucleus Electrophysiology Food intake National...

...Melissa L. Borg; Alex Reichenbach; Moyra Lemus; Brian J. Oldfield; Zane B. Andrews; Matthew J. Watt Background/Aims: Ciliary neurotrophic factor (CNTF) exerts powerful anorectic effects and has been suggested to regulate long-term energy balance by inducing adult neurogenesis in the arcuate nucleus...

...Imre Kalló; Barbara Vida; Zsuzsanna Bardóczi; Anett Szilvásy-Szabó; Fruzsina Rabi; Tamás Molnár; Imre Farkas; Alain Caraty; Jens Mikkelsen; Clive W. Coen; Erik Hrabovszky; Zsolt Liposits Kisspeptin (KP) neurones in the rostral periventricular area of the third ventricle (RP3V) and arcuate nucleus...

... membrane estrogen receptor, to activate sexually receptive behavior in the female rat. Infusions of STX into the arcuate nucleus of the hypothalamus resulted in the activation and internalization of μ-opioid receptors in the medial preoptic nucleus, an action that is required for lordosis behavior. Indeed...

... 2000;133:547–551. 44. Silver IA, Erecinska M: Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J Neurophysiol 1998;79:1733–1745. 45. Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ: The arcuate nucleus as a conduit for diverse signals relevant to energy...

..., instructions or products referred to in the content or advertisements. 2010 Body weight regulation Neuropeptide Y Pro-opiomelanocortin Arcuate nucleus Diet-induced obesity Calorie restriction Growth hormone secretagogue receptor Glucose homeostasis Food intake Food intake and energy...

... < 0.05). In a separate experiment to evaluate responsivity to i.c.v. leptin, the minimal dose of leptin required to significantly reduce 24-hour caloric intake did not differ between the groups. In the arcuate nucleus, POMC mRNA was elevated after a lower dose of i.c.v. leptin in KD rats (5 µg) than...

... component of sex-specific response desensitization. The glucokinase (GK) enzyme functions as a glucose sensor in a body-wide system of metabolic monitoring structures, including the brain, and is expressed at high levels in the hypothalamic arcuate nucleus (ARH). Method: Quantitative real-time RT-PCR...

... system Arcuate nucleus Neuropeptide Y Pro-opiomelanocortin Blood brain barrier Fundamental to the control of food intake is the interaction between the central nervous system (CNS) and peptide hormones released into the circulation from the gastrointestinal (GI) tract. Peripheral signals...

... present in the suprachiasmatic nucleus. In the medial hypothalamus, numerous expressing cells were detected in the dorsomedial and ventromedial nuclei. The arcuate nucleus was moderately labeled throughout its rostrocaudal extent; labeled cell bodies were visible in the ventromedial and ventrolateral...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Obesity Leptin receptor Immunocytochemistry Choroid plexus Clinical neuroendocrinology Paraventricular nucleus Dorsomedial nucleus Supraoptic nucleus Arcuate nucleus...

...Suzanne L. Dickson; Odile Viltart; Alex R.T. Bailey; Gareth Leng We set out to determine whether the central action of growth hormone (GH) secretagogues to induce Fos protein expression in the arcuate nucleus is influenced by central somatostatin action. Conscious male rats were injected i.v...