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1-20 of 30
Keywords: Apoptosis
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Journal Articles
Subject Area:
Topic Article Package: ADC (Antibody-Drug Conjugates)
,
Karger e-Journal Backfile Collection 2023
,
Endocrinology
,
Neurology and Neuroscience
Biaolin Zheng, Xiubing Chen, Fengping Chen, Xiaomin Liao, Feng Wang, Zhe Yang, Nan Yi, Xiaoyan Shi, Shanyu Qin, Haixing Jiang
Journal:
Neuroendocrinology
Neuroendocrinology (2023) 113 (6): 641–656.
Published Online: 30 May 2023
... in recent years. In this study, we confirmed the effects on apoptosis in insulinoma cell lines induced by 5-iodotubercidin and tried to illuminate the underlying mechanisms. Methods: We used 5-iodotubercidin in the treatment of insulinoma cells and the cell proliferation was examined using CCK-8 assay...
Journal Articles
Jan Homolak, Ana Babic Perhoc, Ana Knezovic, Jelena Osmanovic Barilar, Fatma Koc, Catherine Stanton, R. Paul Ross, Melita Salkovic-Petrisic
Journal:
Neuroendocrinology
Neuroendocrinology (2022) 112 (8): 744–762.
Published Online: 04 October 2021
..., instructions or products referred to in the content or advertisements. 2021 Graphic Abstract Streptozotocin Alzheimer’s disease Intestine Brain-gut axis Intestinal barrier Glucose-dependent insulinotropic polypeptide Incretin Oxidative stress Apoptosis Alzheimer’s disease (AD...
Journal Articles
Alessandra Dicitore, Maria Giulia Bacalini, Davide Saronni, Germano Gaudenzi, Maria Celeste Cantone, Giulia Gelmini, Elisa Stellaria Grassi, Davide Gentilini, Maria Orietta Borghi, Anna Maria Di Blasio, Luca Persani, Paolo Garagnani, Claudio Franceschi, Giovanni Vitale
Journal:
Neuroendocrinology
Neuroendocrinology (2022) 112 (6): 580–594.
Published Online: 02 August 2021
... cycle, apoptosis, migration, and genome-wide DNA methylation profiling have been evaluated. Results: Both drugs showed a prominent antitumor activity in DU-145 and PC-3 cells, through perturbation of cell cycle progression, induction of apoptosis, and inhibition of cell migration. AZA and SAM reversed...
Journal Articles
Alessandra Dicitore, Maria Celeste Cantone, Germano Gaudenzi, Davide Saronni, Silvia Carra, Maria Orietta Borghi, Manuela Albertelli, Diego Ferone, Leo J. Hofland, Luca Persani, Giovanni Vitale
Journal:
Neuroendocrinology
Neuroendocrinology (2021) 111 (10): 937–950.
Published Online: 19 October 2020
...: The effects of lanreotide (LAN) and TBR-065 on cell growth and proliferation, calcitonin (CT) secretion, cell cycle, apoptosis, cell migration, and tumor-induced angiogenesis have been evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, DNA flow cytometry with propidium...
Journal Articles
Nataly de Dios, Santiago Orrillo, Martín Irizarri, María Susana Theas, Florence Boutillon, Marianela Candolfi, Adriana Seilicovich, Vincent Goffin, Daniel Pisera, Jimena Ferraris
Journal:
Neuroendocrinology
Neuroendocrinology (2019) 108 (2): 84–97.
Published Online: 07 March 2019
... in GH3 cells and contributes to PRL-induced apoptosis by increasing the Bax/Bcl-2 ratio, (ii) PRL inhibits ERK1/2 and Akt phosphorylation, thereby contributing to its proapoptotic effect, and (iii) the PI3K/Akt pathway participates in the PRL-mediated control of lactotrope proliferation. We hypothesize...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (2016) 103 (5): 578–591.
Published Online: 28 October 2015
... with VPA and examined with respect to cell viability, cell cycle arrest, apoptosis, and global transcriptional response. Results: We found that VPA induced a dose-dependent growth inhibition of NET cells in vitro , which was mainly due to activation of extrinsic and intrinsic apoptotic pathways. VPA...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (2015) 102 (4): 311–326.
Published Online: 29 May 2015
...Michaela Fredrich; Elmar Christ; Amin Derouiche; Horst-Werner Korf Background/Aims: Cell proliferation and apoptosis are known to adjust neuroendocrine circuits to the photoperiod. The latter is communicated by melatonin, the hormone secreted by the pineal organ. The present study investigated...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (2013) 98 (3): 171–179.
Published Online: 19 September 2013
...Jimena Ferraris; Sophie Bernichtein; Daniel Pisera; Vincent Goffin The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been...
Journal Articles
Ryosuke Kimura, Masahiro Okouchi, Takashi Kato, Kenro Imaeda, Naotsuka Okayama, Kiyofumi Asai, Takashi Joh
Journal:
Neuroendocrinology
Neuroendocrinology (2013) 97 (4): 300–308.
Published Online: 14 December 2012
... encephalopathy, we focused on the protective action of glucagon-like peptide-1 (GLP-1) against neural cell apoptosis. In this study, we evaluated whether exposure of cells to GLP-1 leads to epidermal growth factor receptor (EGFR) transactivation and signaling through the PI3K/Akt/mTOR/GCLc/redox pathway, which...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (2013) 97 (3): 232–241.
Published Online: 02 November 2012
... signaling and Nrf2-Keap1 antioxidant defense pathway and attenuates Hcy cytotoxicity. 20 02 2012 9 08 2012 2 11 2012 Akt/GSK-3β Apoptosis 17β-estradiol Homocysteine Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 Reactive oxygen species...
Journal Articles
Marianela Candolfi, Gabriela Jaita, Verónica Zaldivar, Sandra Zárate, Daniel Pisera, Adriana Seilicovich
Journal:
Neuroendocrinology
Neuroendocrinology (2004) 80 (2): 83–91.
Published Online: 09 June 2010
...Marianela Candolfi; Gabriela Jaita; Verónica Zaldivar; Sandra Zárate; Daniel Pisera; Adriana Seilicovich We previously reported that tumor necrosis factor-α (TNF-α) inhibits cell proliferation whereas it stimulates apoptosis of anterior pituitary cells in an estrogen-dependent manner. Also, we...
Journal Articles
Christian Schaaf, Bing Shan, Chiara Onofri, Günter K. Stalla, Eduardo Arzt, Tobias Schilling, Marcelo J. Perone, Ulrich Renner
Journal:
Neuroendocrinology
Neuroendocrinology (2010) 91 (2): 200–210.
Published Online: 17 February 2010
.... Fluorescence-activated cell-sorting (FACS) analysis demonstrated curcumin-induced cell cycle arrest at G 2 /M accompanied by inhibition of cyclin D 1 protein expression. Curcumin had a small effect on necrosis of TtT/GF cells, but it mainly stimulated apoptosis as demonstrated by FACS analysis (Annexin V...
Journal Articles
Bromocriptine and Dopamine Mediate Independent and Synergistic Apoptotic Pathways in Pituitary Cells
Journal:
Neuroendocrinology
Neuroendocrinology (2010) 91 (3): 256–267.
Published Online: 29 January 2010
... on proliferation or lead to tumour shrinkage are incompletely understood. To identify the mediators in the apoptotic cascades after DA or DA agonist challenges we used a well-characterized model system, the rodent somatolactotroph cell line GH3. In these cells, we show that apoptosis induced by the DA agonist...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (2010) 91 (2): 121–130.
Published Online: 14 November 2009
..., which was previously reported to interfere with the mitotic spindle integrity checkpoint and chromosome segregation, but does not interfere with other kinases when used up to 5 µ M . Methods: We evaluated the antineoplastic effects of ZM447439 on growth and apoptosis of the GEP-NET cell lines BON, QGP-1...
Journal Articles
Verónica Zaldivar, María Laura Magri, Sandra Zárate, Gabriela Jaita, Guadalupe Eijo, Daniela Radl, Jimena Ferraris, Daniel Pisera, Adriana Seilicovich
Journal:
Neuroendocrinology
Neuroendocrinology (2009) 90 (3): 292–300.
Published Online: 14 August 2009
... participating in anterior pituitary homeostasis during the estrous cycle. The balance of pro- and antiapoptotic proteins of the Bcl-2 family is known to regulate cell survival and apoptosis. Aims: In order to understand the mechanisms underlying apoptosis during the estrous cycle, we evaluated the expression...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (1993) 57 (1): 89–95.
Published Online: 08 April 2008
...Moreen Drewett; Joan Maty Jacobi; Lesley Ann Willgoss; Henry Martyn Lloyd Apoptosis was investigated by electron and light microscopy in the anterior pituitary gland of the male Fischer rat in which hyperplasia of prolactin-secreting cells had been induced by estrogen implanted subcutaneously for 6...
Journal Articles
Daniela B. Radl, Sandra Zárate, Gabriela Jaita, Jimena Ferraris, Verónica Zaldivar, Guadalupe Eijo, Adriana Seilicovich, Daniel Pisera
Journal:
Neuroendocrinology
Neuroendocrinology (2008) 88 (1): 43–52.
Published Online: 06 February 2008
... (6-OHDA), induce apoptosis in different cell types. DA receptors and DA transporter (DAT) were implicated in this action. Considering that estradiol sensitizes anterior pituitary cells to proapoptotic stimuli, we investigated the effect of estradiol on the apoptotic action of DA and 6-OHDA...
Journal Articles
Journal:
Neuroendocrinology
Neuroendocrinology (2007) 84 (4): 217–221.
Published Online: 05 March 2007
..., has been reported by numerous investigators in this tumour type. More recently, a search for novel genes on the basis of their inappropriate methylation has led to identification of a novel pro-apoptotic gene. Its pituitary tumour derivation and role in drug-induced apoptosis resulted in the acronym...
Journal Articles
Dorothee Karhoff, Susanne Sauer, Jörg Schrader, Rudolf Arnold, Volker Fendrich, Detlef K. Bartsch, Dieter Hörsch
Journal:
Neuroendocrinology
Neuroendocrinology (2007) 85 (1): 45–53.
Published Online: 05 March 2007
... explored the effect of suppressing B-Raf kinase by the recently developed inhibitor BAY43-9006 (Sorafinib) on growth, apoptosis and MAPK activation neuroendocrine cell lines. Methods and Results: Expression of Rap1 and B-Raf in dNETs (19 insulinomas, 15 carcinoid tumors and 10 gastrinomas) was examined...
Journal Articles
Kathrin Zitzmann, Enrico N. De Toni, Stephan Brand, Burkhard Göke, Jennifer Meinecke, Gerald Spöttl, Heinrich H.D. Meyer, Christoph J. Auernhammer
Journal:
Neuroendocrinology
Neuroendocrinology (2007) 85 (1): 54–60.
Published Online: 19 February 2007
... pancreatic NET cell line that exhibits constitutively activated PI(3)K/Akt/mTOR signaling. Methods: BON cells were treated with different concentrations of RAD001 to analyze its effect on cell growth using proliferation assays. Apoptosis was examined by Western blot analysis of caspase-3/PARP cleavage...
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