...Siyuan Zhu; Yidan Pang; Xiangwei Zhang; Chunying Yang; Junjie Gao; Ping Fang; Yaohui Zhang; Yunjin Yao; Fangyu Ju; Fang Ye; Hongyi Zhu; Peng Liao; Lufeng Yao; Lulu Dai; Jun Xu; Bo Wu; Jun Pan; Yijun Wu Introduction: Aging is characterized by the deterioration of a wide range of functions in tissues...

...Marina Caputo; Chiara Mele; Alice Ferrero; Ilaria Leone; Tommaso Daffara; Paolo Marzullo; Flavia Prodam; Gianluca Aimaretti Aging and age-related diseases represent hot topics of current research. Progressive damage in morphology and function of cells and tissue characterizes the normal process...

...Charity Smith; Jo Contreras-Garza; Rebecca L. Cunningham; Jessica M. Wong; Philip H. Vann; Daniel Metzger; Ella Kasanga; Anthony Oppong-Gyebi; Nathalie Sumien; Derek A. Schreihofer Introduction: An increasing number of middle-aged men are being screened for low testosterone levels and the number...

..., the association between interrupted sleep and neurodegeneration, and the possible therapeutic effect of melatonin on these processes. [email protected] 15 07 2018 26 10 2018 28 10 2018 © 2018 S. Karger AG, Basel 2018 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

... reported to play a protective role against cerebrovascular pathologies. Here we aimed to determine the potential effects of E2 on the integrity of BBB and brain damage following middle cerebral artery occlusion (MCAO). Methods: Aged (24- month-old) ovariectomized female rats were administered E2 for 2...

...Fangzhen Xia; Ningjian Wang; Bing Han; Qin Li; Yi Chen; Chunfang Zhu; Yingchao Chen; Xiaoqi Pu; Zhen Cang; Chaoxia Zhu; Meng Lu; Ying Meng; Hui Guo; Chi Chen; Dongping Lin; Junke Zheng; Lin Kuang; Weiping Tu; Bin Li; Lin Hu; Zhoujun Shen; Yingli Lu Background: Aging is associated with variations...

... to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions...

...Johannes Friedrich Georg Neuhaus; Olivier Richard Baris; Anne Kittelmann; Katrin Becker; Markus Alexander Rothschild; Rudolf Josef Wiesner Background: Aging is a multifactorial process characterized by organ loss of function and degeneration, but the mechanisms involved remain elusive. We have...

... vasculature that transports hypothalamic neurohormones to the anterior pituitary gland. The ultrastructure of the ME is dynamically regulated by hormones and undergoes organizational changes during development and reproductive cycles in adult females, but relatively little is known about the ME during aging...

... the hypothalamus of rhesus macaques during aging, especially in the KNDy neurons of the arcuate-median eminence (ARC-ME) that produce kisspeptin, neurokinin B, and dynorphin A. Little is known, however, about the mechanisms involved in mediating the feedback from estrogen onto these neurons. Methods: We used...

... neurons and whether this changes with aging and/or E 2 treatment. We used immunofluorescence double-labeling to characterize the co-expression of GPER in GnRH perikarya and terminals in the hypothalamus. Young and aged rhesus macaques were ovariectomized and given long-term (∼2-year) hormone treatments (E...

...Karine Bédard; Julie Bédard; Ghislain Rocheleau; Guylaine Ferland; Pierrette Gaudreau Dietary interventions involving caloric restriction represent a powerful strategy to prevent or delay age-related deteriorations and diseases. Their beneficial effects have been observed in several tissues...

... of the neurosteroidogenic enzyme, P450scc, were also measured in brain homogenates. 10 01 2011 28 06 2011 5 10 2011 Luteinizing hormone Alzheimer’s disease Aging Guinea pig Gonadectomy GDX Beta amyloid Cerebrospinal fluid Brain Cortical placement Age-associated reductions in sex...

...Laurent Gautron; Véronique De-Smedt; Sophie Layé The pituitary gland undergoes important changes in cellular plasticity throughout life, consequently leading to hormonal output changes. The intermediate filament nestin plays a crucial role in cells that retain plasticity during development, aging...

... and whether it changes in relation to aging and Alzheimer’s disease (AD). Methods: Immunoreactivity (-ir) for TADDI was assessed on postmortem human brain material from a total of 116 cases. Results: The highest levels of this splice form were found in the hypothalamic supraoptic nucleus (SON), pontine nuclei...

...Ettore Ferrari; Flavia Magri; Dino Dori; Giuseppe Migliorati; Tiziana Nescis; Gianna Molla; Marisa Fioravanti; Sebastiano Bruno Solerte Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters...

...Richard J. Krieg, Jr.; Amelia N. Brito; Timothy E. Sayles; Dennis W. Matt Several studies have shown that a certain subpopulation of middle-aged rats have an attenuated preovulatory LH surge, and that this is an early indicator of a general decline in reproductive cyclicity. The pituitary glands...

...Isao Shimokawa; Yoshikazu Higami; Tomoaki Okimoto; Takayoshi Ikeda To elucidate the mechanisms of the impaired pituitary response to growth hormone-releasing hormone (GHRH) in aged animals on a cellular basis, a reverse hemolytic plaque assay was performed on dispersed pituitary cells from young (8...

...William E. Sonntag; Xiaowei Xu; Rhonda L. Ingram; Anselm D’Costa Although growth hormone secretion decreases with age in both animals and man, its potential role in the regulation of biological aging is unknown. In a series of experiments, age-related changes in growth hormone secretory dynamics...

... are important sites of neuroendocrine integration. On the basis of our past and present data, we propose a model of Glu-GABA-GnRH neurointeractions which may help mediate GnRH secretion in the monkey hypothalamus. 9 4 2008 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer...