... cancer typically occurs in older patients (>65 years). As age is often accompanied by cognitive decline, it may impact the efficacy of any treatment aimed at restoring cognitive impairment induced by ADT. Vortioxetine, a multimodal antidepressant that improves cognition in depression, has been shown...

...Ferdinand Roelfsema; Johannes D. Veldhuis Background: Studies on 24-hour growth hormone (GH) secretion are rare. The influences of sex, age, and adiposity are well recognized but generally derived from specific, selected subject groups, not spanning sexes, many age decades, and a range of body...

... influence on pineal melatonin secretion seems to vary with age. Furthermore, age-related fluctuation of systemic blood melatonin appeared to be the results of changes in the rate of pineal melatonin secretion, body growth and ageing. 4 4 2008 © 1991 S. Karger AG, Basel 1991 Copyright / Drug...

...Jukka Jolkkonen; Leena Tuomisto; Tjeerd B. van Wimersma Greidanus; Esa Läärä; Paavo J. Riekkinen In male and female rats of two different age groups, we measured the arginine-vasopressin (AVP) levels in cerebrospinal fluid (CSF) collected at different times of the day. Mean values of AVP...

...Nancy Telford; Charles V. Mobbs; Yagya N. Sinha; Caleb E. Finch We describe how the increase of anterior pituitary dopamine (DA) during aging in female mice is related to altered secretion of ovarian steroids during reproductive senescence. A number of age-correlated neuroendocrine changes...

...Steven R. Gambert These studies investigated the effect of aging on thyroid hormone regulation of β-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of β-endorphin declined with age. In addition, age modified the response of β-endorphin to thyroid hormone status...

...S.R. Gambert; T.L. Garthwaite; C.H. Pontzer; T.C. Hagen Aging is associated with alterations in mood, thermoregulation, pain threshold, and stress response. Because these functions may be modulated by endogenous opiates, we measured immunoreactive ACTH and β- endorphin in discrete brain areas...

...Matilde A. Holzwarth; Charles W. Wilkinson; Mary F. Dallman We measured adrenal weights 3 days after left- or sham-adrenalectomy in male Sprague-Dawley rats at 10 ages between 10 and 155 days. Compared to sham-operated rats, the magnitude of the increase in right adrenal weight ranged between 19...

..., and pituitary GH content and concentration as a function of hamster age. In contrast to responses noted in rats, the stress of ether anesthesia and i.e. puncture caused significant increases in serum GH. A decrease in the serum GH concentration was observed in hamsters at the age 2 to 16 days. Pituitary GH...

... metabolized into more polar derivatives in the neonatal rat. 6 01 1970 20 04 1970 19 3 2008 © 1970 S. Karger AG, Basel 1970 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized...

.... 5-Hydroxytryptoρhan-decarboxylase activity 5-Hydroxytryptamine 5-Hydroxytryptophan Pineal gland Age Light © 1970 S. Karger AG, Basel 1970 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

... partially reduced this response in weanlings. The failure of basal hypothalamic implants of corticoids to differentiate between ages in their ability to inhibit this stress response supported the suggestion of extra-hypothalamic inhibitory systems as the loci of the deficit in weanlings. 14 09 1972...

...) and functional (gonadotropin secretion) maturation of the hypothalamus. 23 03 1972 19 11 1972 19 3 2008 © 1973 S. Karger AG, Basel 1973 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

... hospitals, it was found that the over-all incidence o f calcification Melatonin o f the pineal gland was surprisingly low: 5.04% compared with Age the high incidence o f 33-76 % reported in studies on other popula- Sex tion groups. The incidence among the decades, and between the sexes, and the correlation...

...C.L. Kragt; J. Dahlgren Hypothalamic follicle stimulating hormone releasing factor (FSHRF) content, pituitary and plasma follicle stimulating hormone (FSH) concentrations have been determined in female rats between 5 and 75 days of age. FSHRF was present by at least 10 days of age and at levels...

...G.D. Riegle; G.D. Hess Adrenocortical responsiveness to ether vapor stress was measured in young adult (4–6 months) and aged (22–32 months) rats subjected to acute and chronic treatments with dexamethasone. Daily administration of 25 µ g dexamethasone/100 g body weight for 28 days markedly reduced...

...L.J. Grota Plasma testosterone concentrations in unmanipulated animals gradually increased with age reaching a maximum (11.4 ng/2 ml) at 60 days of age followed by a decrement to a plateau of 3.7 ng/ 2 ml at 90 days of age. Handling or shocking animals, either reweaning or postweaning, had...

... and that protein binding and conjugation may inactivate the hormone in its capacity to produce sterility. 3 H-testosterone binding Plasma Hypothalamus Age 30 07 1970 21 12 1970 19 3 2008 © 1971 S. Karger AG, Basel 1971 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

... of 10-month-old rats contain significantly more LH-RH activity than those of younger rats. The possible significance of these findings is discussed. 20 10 1971 13 03 1972 19 3 2008 © 1972 S. Karger AG, Basel 1972 Copyright / Drug Dosage / Disclaimer Copyright: All rights...