... by electrochemical recording while the activity of the HPA axis was estimated by measurement of ACTH in blood samples. A 1 min, 10 Hz stimulation evoked a significant increase of extracellular NA in the PVN as well as an ACTH surge in blood. The NA and ACTH response evoked by stimulation in the 3- to 14-Hz range...

... groups) or sham injection (control groups). After treatment, animals were tested in a transparent open field for either 30 or 60 min and thereafter sacrificed by decapitation. Plasma was collected for adrenocorticotropic hormone (ACTH), corticosterone, β-endorphin (β-EP) and interleukin-6 (IL-6...

.... In an attempt to distinguish the patterns of ACTH response to oCRH in different forms of anterior pituitary hypersecretion, 17 patients with pituitary adenoma and 17 without pathological evidence of adenoma were studied. These patients underwent transsphenoidal pituitary surgery by the same surgeon and were...

...Andreas Kjær; Ulrich Knigge; Flemming W. Bach; Jørgen Warberg We investigated in conscious, male rats (1) whether the role of arginine-vasopressin (AVP) in histamine (HA)- and/or restraint stress-induced stimulation of ACTH and β-endorphin (β-END) secretion is mediating and/or permissive and (2...

...I. Caroline McMillen; Jennifer J. Merei We have investigated whether increasing gestational age has an effect on basal and K + - or CRF-stimulated ACTH secretion from slices of anterior pituitary from fetal sheep. We have also determined whether cortisol acts to inhibit basal or CRF-induced ACTH...

... in part, to augmented ACTH secretion. Thus, ACTH levels were measured in 24-hour maternally deprived and nondeprived 6-, 9-, and 12-day-old pups exposed to a mild stressor (i.e. saline injection followed by placement in a novel environment at room temperature). The results showed: (1) nondeprived pups...

... that the nadir of the diurnal rhythm in corticosterone secretion results in part from neural inhibitory control. Splanchnic neural innervation may also have an excitatory role in the adrenocortical stress response. 29 05 1993 23 09 1993 8 4 2008 Adrenal innervation Splanchnic nerve ACTH...

...Lauren Jacobson; Robert Sapolsky Adrenalectomized rats replaced with constant, physiological levels of corticosterone via a subcutaneous pellet (Pellet) have normal basal morning ACTH but exhibit enhanced and prolonged ACTH responses to stress vs. sham-operated (Sham) rats. It has not been...

... hormone concentrations. To address these controversies, we tested the feedback sensitivity of the anterior pituitary hormone responsible for corticosteroid production, adrenocorticotropin (ACTH), to corticosterone (B), the main corticosteroid in rats, in total fornix- and, as controls, cortex-lesioned...

...Andrew D. Levy; Qian Li; Peter A. Rittenhouse; Louis D. Van de Kar The potential roles of central and peripheral 5-HT3 receptors in the secretion of prolactin, adrenocorticotropic hormone (ACTH), corticosterone and renin was investigated. Male rats received the 5-HT 3 antagonist ondansetron (0, 0.1...

... of neurosecretory vesicles from immunocytochemically identified axons in the external zone of the median eminence. The habituated, vehicle-injected sham control group had normal levels of plasma ACTH and corticosterone, but possessed a significantly higher proportion of VP-containing CRH axons than naive animals...

...Wolfgang Schreiber; Thomas Pollmächer; Klaus Fassbender; Susanne Gudewill; Helmut Vedder; Klaus Wiedemann; Chris Galanos; Florian Holsboer The present study compares the effects of endotoxin, a key factor in gram-negative bacterial infection, and of corticotropin-releasing hormone (CRH) on ACTH...

... during a period of 15 min. Control rats (C) were placed in the shock apparatus for 15 min without receiving shocks. The effects of these experimental procedures were studied 14 days later. Exposure to shocks did not affect basal plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone (CORT...

... rats. Treatment with CRF-1–41, in a dose-related fashion, produced a significant rise in plasma ACTH, whereas CRF-34–41 was without effect. Finally, the effect of i.c.v. injected CRF-1–41 and CRF fragments on heart rate (HR) and gross activity was measured in conscious rats in their home cages during...

... for corticotropin-releasing hormone (CRH) secretion or is a manifestation of glucocorticoid resistance, we examined plasma ACTH and cortisol responses to the competitive glucocorticoid antagonist RU 486 (10 mg/kg, p.o. at 8.00 h) versus placebo (PBO) in 7 healthy female volunteers and 8 patients with DSM-III-R...

... phase. Instead, a constant exposure to corticosterone at approximately 50% of the daily mean (2.4-3 µg/dl) appears to be sufficient for regulation of the mRNA rhythm. Additionally, corticosterone replacement achieving a lower concentration of 1.5 µg/dl seems effective in regulating basal ACTH secretion...

... (HPA) axis in humans. ACTH and cortisol plasma concentrations were measured in 8 patients hourly starting from 4 p.m. through 12 p.m. on three occasions. The first time all patients were studied before initiation of therapy, when the vehicle was injected alone. The patients were studied again on day 1...

...Andreas Kjær; Ulrich Knigge; Hans Vilhardt; Flemming W. Bach; Jørgen Warberg Arginine-vasopressin (AVP) seems to be involved in the histamine (HA)- and stress-induced release of ACTH and β-endorphin (β-END). We studied the effect of selective AVP V 1 - or V 2 -receptor blockade on the ACTH and β...

... intraperitoneally (ip) at –180 and –60 min) inhibited by 30–80% the responses of prolactin (PRL), corticotropin (ACTH) and β-endorphin (β-END) immunoreactivity to 1, 2.5 or 5 min of restraint stress (p < 0.05–0.01), but had no effect on basal secretion of the hormones. The inhibitory effect of the H 3 receptor...

...Annamaria Colao; Bartolomeo Merola; Mauro Cataldi; Giuseppe La Tessa; Françoise Boudouresque; Charles Oliver; Gianfranco Di Renzo; Lucio Annunziato; Gaetano Lombardi Plasma ACTH, β-endorphin and α-melanocyte-stimulating hormone levels were evaluated in the inferior petrosal sinuses...