In connection with the possibility of hormonal influences upon norepinephrine (NE) metabolism of the central nervous system in the premenstrual tension syndrome and postpartum depression, we examined the effect of progesterone upon NE metabolism in the brain of ovariectomized rats. The comparison of progesterone-treated and untreated rats did not afford significant results. However, progesterone did exert a significant inhibitory effect upon amphetamine-induced NE catabolism. A similar but not significant effect of progesterone was found in stressed rats. The influences of progesterone upon stress-altered NE-metabolism were higher in the telencephalon than in the brain stem.

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