The effect of acute intracerebroventricular (i.e. v.) injection of neuropeptide Y (NPY) on basal and glucose- or arginine-stimulated insulinemia was studied in anesthetized and conscious rats. Basal insulinemia was not significantly increased relative to control values after NPY injection. The insulinemic response to an intravenous bolus of glucose or arginine was unaffected by prior NPY injection, glycemic profiles being identical in control and NPY-injected rats. Plasma NPY concentrations were double the corresponding control values at 20 min after i.e.v. NPY injection, but this difference was not statistically significant. Although peripheral NPY inhibits insulin secretion, these elevated plasma NPY concentrations occurred too late to explain the lack of effect of i.c.v. NPY on substrate-induced insulin secretion. Compared to control rats, marked increases in corticosteronemia were observed after i.c.v. NPY injection in conscious animals. When allowed to eat ad libitum at the end of each experiment, NPY-injected rats consumed significantly more chow in 20 min than controls. We conclude that although acute i.c.v. injection of a maximum dose of NPY had definite effects on plasma corticosterone concentrations and feeding, it favored neither the basal nor the substrate-induced insulin output.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.