Oophorectomy accelerates the turnover of 3H-norepinephrine (3H-NE) in rat brain, but does not decrease endogenous brain norepinephrine content. If ovariectomized rats are treated with a given dose of (α-MPT), an inhibitor of norepinephrine synthesis, brain norepinephrine α-Methyl para-tyrosine levels do not fall to the same extent as in unoperated animals given the same dose of α-MPT, even though the turnover of brain 3H-NE continues to be accelerated. These data indicate that ovariectomy increases brain norepinephrine synthesis, and also decreases the sensitivity of rats to inhibitors of norepinephrine synthesis such as α-MPT. Ovariectomy or treatment with follicle-stimulating hormone (FSH) also increases the accumulation of 3H-catechols (predominantly 3H-NE) in rat brain, following the intraperitoneal administration of 3H-tyrosine.

Keywords:
Ovariectomy, Brain, Norepinephrine, 3H-catechols, α-methyl para-tyrosine, FSH
This content is only available via PDF.
© 1970 S. Karger AG, Basel
1970
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.