Somatostatin-14 inhibited the isoproterenol-stimulated adenylate cyclase in cell-free homogenates of pituitary intermediate lobe of the male rat with a Ki of 7.25 ± 0.31 × 10–7M. Somatostatin-28 was found to be a partial agonist. Other neuropeptides (met- and leuenkephalin, β-endorphin, α-melanocyte-stimulating hormone, ACTH, neurotensin, substance P, vasoactive intestinal polypeptide, and vasopressin) were without effect. Our results suggest a role for pituitary and/or brain somatostatin in the physiological regulation of the intermediate pituitary lobe, and the possibility of an interaction between somatostatins and catecholamines on the regulation of intermediate lobe adenylate cyclase.

Keywords:
Somatostatin, Adenylate cyclase, Intermediate pituitary lobe, Isoproterenol
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© 1983 S. Karger AG, Basel
1983
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