An intraventricular injection of 100 µ g of norepinephrine (NE), but not of dopamine, induced ovulation in more than 50 % of rats made anovulatory by electrolytic lesions in the anterior hypothalamus. Ovulation also occurred 2 days after an intraventricular injection of 50 µ g of NE in more than 50 % of rats made anovulatory by exposure to continuous illumination. The percentage of rats which ovulated after the intraventricular injection of 100 µ g of NE was much lower in rats made anovulatory by a frontal cut in the anterior hypothalamus or by the neonatal administration of testosterone than in rats made anovulatory from either anterior hypothalamic lesions or continuous illumination. The results of this experiment suggest that when they are stimulated by NE the LRF-producing neurons in rats made anovulatory by various experimental procedures do synthesize and release LRF in an amount sufficient to induce ovulation.

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.