An intraventricular injection of 100 µ g of norepinephrine (NE), but not of dopamine, induced ovulation in more than 50 % of rats made anovulatory by electrolytic lesions in the anterior hypothalamus. Ovulation also occurred 2 days after an intraventricular injection of 50 µ g of NE in more than 50 % of rats made anovulatory by exposure to continuous illumination. The percentage of rats which ovulated after the intraventricular injection of 100 µ g of NE was much lower in rats made anovulatory by a frontal cut in the anterior hypothalamus or by the neonatal administration of testosterone than in rats made anovulatory from either anterior hypothalamic lesions or continuous illumination. The results of this experiment suggest that when they are stimulated by NE the LRF-producing neurons in rats made anovulatory by various experimental procedures do synthesize and release LRF in an amount sufficient to induce ovulation.

Keywords:
Ovulation, Norepinephrine, Dopamine, Hypothalamic lesion, Frontal deafferentation, Androgen sterilization, Continuous illumination
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© 1974 S. Karger AG, Basel
1974
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