Bilateral lesions produced with a platinum electrodewere placed in the anterior or central parts of the mediocortical amygdaloid nuclei, or in the anterior and basal region of the ventral hippocampus of 22-day-old female rats, and the effects on vaginal opening (VO), first puberal ovulation and subsequent vaginal cyclicity were recorded. Lesioning of the anterior part of the amygdaloid mediocortical nuclear complex resulted in precocious puberty, whereas lesions located in the central parts of these nuclei did not influence the onset of puberty. On the other hand, a significant delay of VO and the first ovulation was observed after bilateral hippocampal damage. The results suggest an inhibitory action of the anterior mediobasal amygdala on the prepuberal gonadotropin secretion and indicate a reciprocal relationship between the anterior amygdala and the ventral hippocampus in the control of female puberty.

Keywords:
Amygdaloid lesions, Hippocampal lesions, Early puberty, Delayed puberty
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© 1974 S. Karger AG, Basel
1974
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