The effect of fornix transection on the diurnal fluctua-tion in plasma corticosterone levels was investigated in adult male rhythm rats. Using the stereotaxic approach, the fornix was cut by means of a small piece of a razor blade. Plasma corticosterone levels at 8 a.m. and 6 p.m. were measured 1 week or 3 weeks after surgery. There was no diurnal variation in the plasma corticosterone concentration 1 week after fornix transection. At 3 weeks post-operatively, however, significant diurnal variations were present. The data suggest that, contrary to the assumption of other authors, the fornix is not the key structure in the mediation of extrahypothalamic influences to the medial basal hypothalamus that are essential for the diurnal rhythm in plasma corticosterone levels.

Keywords:
ACTH, Biological rhythms, Fornix, ACTH, Corticosterone
This content is only available via PDF.
© 1973 S. Karger AG, Basel
1973
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.