... Sodium-glucose cotransporter-2 inhibitors Chronic kidney disease Uric acid Kidney stones A recent exploratory analysis of the 2-year EMPA-KIDNEY Trial reported that the use of empagliflozin (10 mg daily) in subjects with chronic kidney disease (CKD) with eGFR varying from 20 mL/min/1.73 m 2...

...AbdelAal Mohammed; Mohamed A. Marie; Dina O. Abdulazim; Mohammed Hassan; Olfat Shaker; Ghada Ayeldeen; Mona M. Salem; Usama A. Sharaf El Din; on behalf of the Egyptian Vascular Calcification Group (VCG) Background: Recent studies have demonstrated negative associations of serum uric acid (SUA...

...Abutaleb Ahsan Ejaz; Richard J. Johnson; Michiko Shimada; Rajesh Mohandas; Kawther F. Alquadan; Thomas M. Beaver; Vijay Lapsia; Bhagwan Dass Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease...

... factor and solute depletion a secondary one. Methods. We compared the level of cation (Na + K) depletion and water balance in patients with high or low uric acid levels (< 4 mg/dL or 238 µmol/L) or with high or low (< 30 mg/dL or 5 mmol/L) urea levels. Data were collected from 15 consecutive...

... predictor of cardiovascular events in CKD and HD patients, regardless of uric acid levels. Uric acid was not predictive of events. Conclusion: This highlights a possible role of XO itself in CKD-related cardiovascular disease (CVD) and raises the hypothesis that beneficial effects observed with XO...

... acid and oxypurinol and decreased the plasma concentration of oxypurinol. However, it affected neither the urinary excretion, the fractional clearance, the plasma concentration of oxypurines nor the plasma concentration of uric acid. These results indicate that amino acids affect the renal transport...

...Eugenia Miranda-Carús; Felicitas A. Mateos; Antonio G. Sanz; Elisa Herrero; Teresa Ramos; Juan G. Puig Primary gout is characterized by increased plasma and decreased urinary concentrations of hypoxanthine, xanthine and uric acid. To examine whether lead could explain the disturbance of purine...

... clearances of uric acid, xanthine and oxypurinol were significantly increased during glucose infusion, but that of hypoxanthine was not changed, while a 1-hour infusion of 500 ml of 1.1 M mannitol had no effect on the fractional clearances of purine bases and oxypurinol. These data indicate that the effect...

... infusion decreased the fractional clearance of uric acid, but the fractional clearances of hypoxanthine, xanthine and oxypurinol were not affected. These results suggest that uric acid and lactic acid share the renal transport system of organic acids but hypoxanthine, xanthine and oxypurinol do...

...) and the renal uric acid clearance was 3 times higher than that of the controls, establishing a diagnosis of renal hypouricemia. Xanthine and hypoxanthine concentrations in the plasma were elevated to 1.3 ± 0.1 μmol/l (controls, 0.5 ± 0.3) and 5.9 ± 3.5 μmol/l (controls, 1.6 ± 0.4), respectively. Both renal...

...Alexander Erdberg; Geoffrey Boner; David J. van Dyk; Raphael Carel Serum uric acid has been described as being increased in the prediabetic stage of diabetes mellitus and as being decreased in overt diabetes. In this study we compared the serum uric acid levels of patients with insulin-dependent...

... of gout and finally a rapidly progressing renal failure 17 months after transplantation. The removed transplanted kidney showed extensive tubular dilatation, intratubular deposits of uric acid crystals and characteristic granulomas. There was also morphologic evidence of transplant glomerulopathy, as well...

...A. Conte; P. Roca; C. Genestar; F. Grases Uric acid is implicated in calcium oxalate kidney stone formation. Conspicuously so far, two hypotheses have been proposed: direct induction of calcium oxalate precipitation by uric acid, and uric acid as anti-inhibitor by binding urinary glycosaminoglycans...

...G. Decaux; B. Hanson; P. Cauchie; D. Bosson; J. Unger We have suggested that cirrhotic patients with high uric acid clearances had an increased effective vascular volume. This hypothesis was tested by studying the relationship between the excretion of uric acid, sodium, potassium, and aldosterone...

...A. Andrés; M. Praga; L.M. Ruilope; J.M. Martínez; V.G. Millet; I. Bello; J.L. Rodicio A 12-year-old boy presented with acute renal failure (ARF) accompanied by a disproportionate increase of serum uric acid level and massive uric acid crystalluria. After alkalinization and allopurinol therapy...

...G. Decaux; I. Dumont; Y. Waterlot; B. Hanson Hypouricemia seen with hyponatremia related to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) results from an increase in uric acid renal clearance. We studied the mechanism of the increase of uric acid excretion in 6 SIADH...

...J.C. Roos; P. Boer; K.H. Peuker; Dorhout Mees Intrarenal handling of uric acid was studied in 12 patients with essential hypertension under spironolactone treatment (200 mg/day). The degree of volume depletion during treatment was assessed from the changes in body weight and plasma renin activity...

...T.H. Steele; B.A. Stromberg; J.L. Underwood We utilized an isolated perfusion rat kidney preparation to assess the influence of uric acid on p -amino-hippurate (PAH) secretion. In the absence of urate, PAHsecretion averaged 183 µg/min (0.94 µmol/min) at a perfusate PAHconcentration of 3.2 mg/dl...

... kallikrein-like activity (Uĸ a V) increased. Significant relationships were observed between Uĸ a V and urinary aldosterone excretion during the study. Further, there were significant relationships between serum Na and UĸaV, and between uric acid clearance and Uĸ a V. In 1 patient, who was observed...

...John H. Bauer; Charles S. Brooks 25 hypertensive subjects underwent a double-blind, randomized study to compare the effects of ticrynafen (TCNF) with hydrochlorothiazide (HCTZ) on blood pressure (BP), renal function, serum uric acid (UA) and electrolytes, and body fluid spaces. BP was similarly...