... of SNa correction and in 12 patients (6 women and 6 men) before and after 3 months of SNa correction by a vaptan or urea. Results: We confirm a low urine creatinine and solute excretion only in patients with chronic hyponatremia (>1 month). Correction of SNa (from 127 ± 2.3 mEq/L to 139 ± 2.8 mEq/L...

... to frank diabetes. CKD can negatively affect beta cell function through increased levels of urea that reduce beta cell glucose utilization and impair insulin secretion, and possibly also through factors other than urea. It remains to be investigated whether urea and other factors of CKD can also affect...

...Joy L. Logan The hypothesis that protein metabolites regulate renal growth has been considered for decades, and the overall objective of this work was to test this hypothesis in vitro using an established line of renal tubular epithelial cells, NRK-52E. The addition of urea to the medium...

...M.L. Halperin; M. Gowrishankar; J.P. Mallie; H. Sonnenberg; M. Oh Urea absorption in the inner medullary collecting duct provides a mechanism to elevate the concentration of urea in the papillary interstitial fluid and thereby permit the excretion of urea with as little water as possible. Urea...

... comparisons to measure the normalised cellular clearance (KCn). Both variables can be determined from the shape of the rebound curve. KC and KCn were determined in 34 maintenance dialysis patients on two occasions, obtaining the following values: KC urea 502 ± 179 ml/min, KCn urea 7.80 ± 2.42 ml/kg/min, KC...

...Toru Shinzato; Shigeru Nakai; Yoshiro Fujita; Ichiro Takai; Eiroyuki Morita; Kazunori Nakane; Kenji Maeda We developed a new urea kinetic method for simultaneous determination of the Kt/V and protein catabolic rate (PCR) only from blood urea nitrogen (BUN) concentrations before and after a single...

...%) in the interdialytic periods, was present in 33.6% of patients. The highest rate of increase of body weight occurred in the first hours following the end of dialysis sessions. Hypematremia, potassium depletion, increasing plasma urea levels and elevated plasma angiotensin II levels were considered as the possible...

...Jürgen Holtz; Thomas Munzel; Olaf Sommer; Eberhard Bassenge We analyzed the effect of enalapril (0.1 mg/kg p.o. twice daily) on plasma electrolytes, urea, and creatinine in low cardiac output failure. In 14 male dogs implanted with chronic instrumentation, tachycardia was induced by ventricular...

...Sergio Giovannetti; Giuliano Barsotti; Adamasco Cupisti Anephric rats injected subcutaneously with urea in isotonic saline drank much more than anephric control animals receiving isotonic saline alone. The pattern of water intake and urine output of normal rats, repeatedly injected with urea...

... that the patient presented frequent symptoms of water intoxication. Normal natremia was also obtained with a high salt intake (9 g/day) but this induced leg edema, mild dyspnea and gastric intolerance. The patient was however successfully treated for more than 5 years without any side effects with oral urea (30 g...

...G. Decaux; F. Prospert; B. Namias; A. Soupart Our purpose was to compare the effect of urea and indomethacin on solute excretion in hyponatremic patients with inappropriate secretion of antidiuretic hormone (SIADH). In 6 patients (serum Na: 126 ± 3 mmol/l), the intake of urea (0.1 g/kg) induced...

... analysis. ‘Uremic sera’, creatinine, urea, and combinations of these compounds reduce inotropy of the cultured heart cells, induce arrhythmias or asynchronies in a concentration-dependent manner. We propose the myocyte perfusion technique as an in vitro approach to identify cardiotoxins in the body fluids...

... creatinine clearance was 0.56 ml/kg/min and urea clearance 0.80 ml/kg/min. Neither intraperitoneal nor intravenous aminophylline increased peritoneal clearances, nor did the ratio creatinine clearance/urea clearance change from the control value, 0.70. Bidirectional flux of theophylline occurred...

...G. Decaux; P. Mols; P. Cauchie; B. Flamion; F. Delwiche We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics. In 5 patients with hyponatremia and ascites resistant to a major diuretic treatment (200...

...). The plasma urea concentration of BUO rats averaged about five times the values of either sham or UUO groups. The release of BUO of 1-day duration resulted in post-obstructive diuresis and natriuresis, whereas oliguria was observed after the release of UUO of 1-day duration. Contralateral nephrectomy...

... clearance was initially low (44–55 ml/min). He achieved a good control with urea. The usual diuretic dose was 40 mg furosemide or 50 mg ethacrynic acid/day; only 2 patients required higher doses, 80 mg furosemide and 100 mg ethacrynic acid, respectively. Supplementary salt in tablets (3–6 g daily) had...

.... On the contrary, low body mass index ( < 20 kg/m 2 ), low cholesterol ( < 4.5 mmol/l) and low mean predialysis blood urea ( < 4.6 mmol/l) were associated with increased OM and CVM, and more especially with high stroke mortality. Results for urea but not for cholesterol remain significant after adjustment...

... uremic ‘toxins’, urea and guanidinosuccinic acid, were then administered in order to determine if either of these substances would independently alter the kinetics under study. Results indicated that these two compounds have little or no effect on liver function on an acute basis. However, because...

... distribution; hence, in contrast to urea, PK shows a marked postdialytic rebound and the simple equation for solute removal from a single pool cannot predict postdialysis PK. (2) The magnitude of the fall in PK correlated with the predialysis PK; this was not only due to increased potassium removal, but also...

...John W. Lacher; Robert W. Schrier Sweating was induced in 3 uremic patients in an ordinary bathtub for 3 h per day to examine whether clinically significant amounts of urea could be removed. Blood urea concentrations fell in all 3 patients, and 2 of the patients had improvement in uremic syptoms...