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Keywords: Tubulointerstitial fibrosis
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Journal Articles

Pirfenidone Attenuates Renal Tubulointerstitial Fibrosis through Inhibiting miR-21

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Subject Area:
Nephrology
Liangliang Bi, Yanjie Huang, Jing Li, Xiaoqing Yang, Gailing Hou, Panpan Zhai, Qiushuang Zhang, Abubakari Adam Alhaji, Yueli Yang, Bo Liu
Journal: Nephron
Nephron (2022) 146 (1): 110–120.
https://doi.org/10.1159/000519495
Published Online: 01 November 2021
...Liangliang Bi; Yanjie Huang; Jing Li; Xiaoqing Yang; Gailing Hou; Panpan Zhai; Qiushuang Zhang; Abubakari Adam Alhaji; Yueli Yang; Bo Liu Background: Our previous studies had shown pirfenidone (PFD) not only improved tubulointerstitial fibrosis (TIF) but also inhibited the expression of microRNA-21...
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Journal Articles

Two Distinct Epithelial Responses May Compensate for the Ureteral Obstruction in Early and Late Phase of Unilateral Ureteral Obstruction-Treated Rat: Cellular Proliferation in Acute Phase and Osteopontin Expression in Chronic Phase

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Subject Area:
Nephrology
Tsuyoshi Sakai, Hisako Tanaka, Takuji Shirasawa
Journal: Nephron
Nephron (1997) 77 (3): 340–345.
https://doi.org/10.1159/000190298
Published Online: 23 December 2008
... cell nuclear antigen Osteopontin Unilateral ureteral obstruction Macrophage Tubulointerstitial fibrosis NEPHRON Original Paper Nephron 1997:77:340-345 Accepted: April 3. 1997 Tsuyoshi Sakaia_c Hisako Tanakab Takuji Shirasawac Second Department of Internal Medicine. Department of Molecular...
View article titled, Two Distinct Epithelial Responses May Compensate for the Ureteral Obstruction in Early and Late Phase of Unilateral Ureteral Obstruction-Treated Rat: Cellular Proliferation in Acute Phase and Osteopontin Expression in Chronic Phase
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Journal Articles

Progression of Chronic Adriamycin Nephropathy in Leukopenic Rats

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Subject Area:
Nephrology
Fabrizio Ginevri, Antonella Trivelli, Antonio Mutti, Enrico Bergamaschi, Giovanna Fabbretti, Francesco Callea, Gennaro Salvidio, Paola Altieri, Francesco Perfumo, Gian Marco Ghiggeri
Journal: Nephron
Nephron (1993) 63 (1): 79–88.
https://doi.org/10.1159/000187147
Published Online: 12 December 2008
... Adriamycin nephropathy Proteinuria Leukopenic rats Tubulointerstitial fibrosis Progression of renal disease Original Paper Nephron 1993;63:79-88 Fabrizio Ginevri3 Antonelia Trivellia Antonio Mnttih Enrico BergamaschC Giovanna Fabbrettia Francesco Callea8 Gennaro Salvielioc Poola Altieria Francesco...
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Journal Articles

Sustained Expression of Thrombospondin-1 Is Associated with the Development of Glomerular and Tubulointerstitial Fibrosis in the Remnant Kidney Model

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Subject Area:
Nephrology
Christian Hugo, Duk-Hee Kang, Richard J. Johnson
Journal: Nephron
Nephron (2002) 90 (4): 460–470.
https://doi.org/10.1159/000054735
Published Online: 08 April 2002
... to in the content or advertisements. Thrombospondin-1 TGF-β activation Remnant kidney model Glomerulosclerosis Tubulointerstitial fibrosis Glomerulosclerosis and interstitial fibrosis are the two most common histologic features that characterize progressive renal insufficiency [ 1 ]. The remnant...
View article titled, Sustained Expression of Thrombospondin-1 Is Associated with the Development of Glomerular and Tubulointerstitial Fibrosis in the Remnant Kidney Model
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Journal Articles

Relationship between Mast Cells in the Tubulointerstitium and Prognosis of Patients with IgA Nephropathy

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Subject Area:
Nephrology
Atushi Kurusu, Yusuke Suzuki, Satoshi Horikoshi, Isao Shirato, Yasuhiko Tomino
Journal: Nephron
Nephron (2001) 89 (4): 391–397.
https://doi.org/10.1159/000046109
Published Online: 22 November 2001
... nephrotic syndrome were used. There was a significant correlation between the number of mast cells per unit area of the whole tubulointerstitium and the degree of tubulointerstitial fibrosis or renal function. Patients with IgA nephropathy were divided into two groups (group 1: ‘minimal’ and ‘slight’; group...
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Journal Articles

Mizoribine Ameliorates the Tubulointerstitial Fibrosis of Obstructive Nephropathy

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Subject Area:
Nephrology
Norihiro Sato, Kazumi Shiraiwa, Kiyonori Kai, Atsushi Watanabe, Shinichi Ogawa, Yoshiro Kobayashi, Hiroko Yamagishi-Imai, Yasunori Utsunomiya, Tetsuya Mitarai
Journal: Nephron
Nephron (2001) 89 (2): 177–185.
https://doi.org/10.1159/000046065
Published Online: 05 September 2001
... with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstruction (UUO) by inhibiting the infiltration of macrophages. We, therefore, examined the dose dependency of the suppressive effect...
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Journal Articles

Tissue-Specific Expression of Human Angiotensin II AT1 and AT2 Receptors and Cellular Localization of Subtype mRNAs in Adult Human Renal Cortex Using in situ Hybridization

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Subject Area:
Nephrology
Hiroaki Matsubara, Takeshi Sugaya, Satoshi Murasawa, Yoshihisa Nozawa, Yasukiyo Mori, Hiroya Masaki, Katsuya Maruyama, Yoshiaki Tsutumi, Yasunobu Shibasaki, Yasutaka Moriguchi, Yohko Tanaka, Toshiji Iwasaka, Mitsuo Inada
Journal: Nephron
Nephron (1998) 80 (1): 25–34.
https://doi.org/10.1159/000045121
Published Online: 04 September 1998
... of Ang II in the renal and cardiovascular systems are mediated by Ang II receptor type 1 (AT1-R) [ 1, 2, 3 ]. Angiotensin II Angiotensin II type 1 (AT1) receptor Angiotensin II type 2 (AT2) receptor Human kidney In situ hybridization Tubulointerstitial fibrosis 1998 Copyright / Drug...
View article titled, Tissue-Specific Expression of Human Angiotensin II AT1 and AT2 Receptors and Cellular Localization of Subtype mRNAs in Adult Human Renal Cortex Using in situ Hybridization
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