...Mengmeng Pu; Huanhuan Zhao; Silei Xu; Xiaohui Gu; Qiang Feng; Peng Huang Introduction: Sepsis-associated acute kidney injury (SA-AKI) is a common complication of sepsis. miR-340-5p has been identified as an effective biomarker of various human diseases. As the downstream target, the involvement...

...Mingjuan Yan; Ni Zhang; Li Quan; Wei Bin; Jing Xi; Caoshuai Dou; Zhiwen Liu; Yongfeng Gui; Liang-Hong Yin Introduction: Sepsis is the leading contributor to acute kidney injury (AKI), responsible for 45–70% of AKI occurrences. Despite this, septic AKI is a highly multifactorial and complex...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Acute kidney injury miR-874-3p MSRB3 Ischemic-reperfusion Sepsis Acute...

... that are independent of CKD, meaning bone disease prior to the onset, or in the absence of CKD – a form of “post-AKI osteopathy.” While preclinical studies examining bone health after acute stressors have focused mostly on sepsis models, multiple experimental AKI models are readily available for longitudinal bone...

...Kristina Collins; Sarah C. Huen Background: Sepsis continues to cause significant morbidity and mortality despite technological advancements in medical management. While sepsis is defined as organ dysfunction owing to the dysregulated host response to infection, our understanding...

... Renal ischemia-reperfusion injury Sepsis Splenic nerve Vagus nerve stimulation NIH Inoue et al. [ 9 ] illustrated through mouse models of renal IRI that electrical VNS, when applied 24 h or 48 h before ischemia, attenuated cytokine response (e.g., IL-6 and TNF release) and subsequent...

...Hernando Gómez Background: The recognition that sepsis induces acute kidney injury (AKI) in the absence of overt necrosis or apoptosis and even in the presence of increased renal blood flow has led to the consideration that kidney tubular epithelial cells (TECs) may deploy defense mechanisms...

...John A. Kellum; Debra Foster; Paul M. Walker Background: Marked heterogeneity exists among patients with sepsis, both in terms of distribution of organ dysfunction and its severity. Such heterogeneity could be explained by the presence of multiple subtypes of sepsis that may have important...

...Ilaria Godi; Anna Lorenzin; Silvia De Rosa; Gianlorenzo Golino; Maira Knust; Ana Gaspar; Alessandra Sandini; Francesco Fiorin; Massimo de Cal; Paolo Navalesi; Claudio Ronco Introduction: A critical point for using blood purification during sepsis may be the potential interaction with antimicrobial...

...Nabin Poudel; Shuqiu Zheng; Colleen M. Schinderle; Naidi Sun; Song Hu; Mark D. Okusa Understanding and measuring parameters responsible for the pathogenesis of sepsis-induced AKI (SI-AKI) is critical in developing therapies. Blood flow to the kidney is heterogeneous, partly due to the existence...

...Xiaoyan Wen; Jicheng Zhang; Xiaojian Wan; Alicia A. Frank; Xin Qu; John A. Kellum Introduction: Urinary tissue inhibitor of metalloproteinases (TIMP)-2 has been identified as a predictive marker for acute kidney injury (AKI), including sepsis-associated AKI (S-AKI). Whether TIMP-2 might be causally...

...Joy C.Y. Chen; Bo Hu; Ryan D. Frank; Kianoush B. Kashani Background: Sepsis and septic shock are life-threatening causes of acute kidney injury (AKI) frequently seen and managed in intensive care units (ICUs). Sepsis-associated AKI (SA-AKI) independently contributes to the mortality of sepsis...

... have a substantial increased risk of subsequent infection and sepsis. Indeed, sepsis is the leading cause of death in patients with established AKI. Unfortunately, little is known regarding the nature of the abnormal immune response that increases the risk for septic complications which may...

...Jonathan Montomoli; Abele Donati; Can Ince Acute kidney injury (AKI) is a common complication in critically ill patients, especially among septic patients. Sepsis and hypovolemia are the 2 most frequent etiologies of AKI in intensive care units and frequently coexist in critically ill patients...

...Hernando Gómez; Kui Jin; John A. Kellum Sepsis is considered today a major public health problem. Despite that mortality has been consistently associated with organ compromise, the mechanisms by which sepsis causes multiple organ dysfunction are not well understood, and hence, therapy remains...

...Gordon P. Otto; Benedikt Grünwald; Christian Geis; Susanne Köthe; Jorge Hurtado-Oliveros; Ha-Yeun Chung; Michael Ekaney; Clemens L. Bockmeyer; Maik Sossdorf; Martin Busch; Ralf A. Claus Background/Aims: Long-term kidney affections after sepsis are poorly understood. Animal models for investigating...

...Raja I. Zabaneh; Divyesh M. Bhatt; Alex W. Yu; Paritosh Tiwari; Catherine I. Lai; David J. Leehey; Todd S. Ing An elderly man with end-stage renal disease required intensive hemodialysis therapy because of sepsis-induced hypercatabolism. We were able to prevent the occurrence of hypophosphatemia...

... importance of age, prior chronic disease (including chronic renal failure), sepsis and organ system failure, for development and outcome of ARF in the medical ICU. Of 487 consecutively admitted patients, 78 (16%) had ARF, in 63% treated with renal replacement therapy. Mortality was 63%. Independently from...

...John M. Richmond; William J. Sibbald; Anne M. Linton; Adam L. Linton Urine protein excretion patterns have been studied in 42 patients with sepsis and compared with that in 21 healthy controls. Patients with sepsis were shown to have highly significant increases in fractional clearances for β 2...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Septic Arthritis Hemodialysis Sepsis Arthritis 14 05 1979 2 12 2008 Nephron 25: 87-91 (1980) Septic...