...-induced (50 mg/kg, i.p.) diabetic rats treated with oral camostat mesylate for 12 weeks. The rats were divided into three groups: (1) nondiabetic control rats; (2) diabetic rats, and (3) diabetic rats received rat chow containing 0.1% camostat mesylate (PI rats). After induction of diabetes, the ratio...

...Osama A. Badary; Mahmoud N. Nagi; Hussein A. Al-Sawaf; Mohammed Al-Harbi; Abdullah M. Al-Bekairi The effect of L -histidinol (LHL) on the acute nephrotoxicity produced by cisplatin (CDDP; 6 mg/kg, i.v.) was investigated in the rat. Intraperitoneal administration of LHL (100 mg/kg × 5 doses, 2 h...

...Takako Yokozawa; Erbo Dong; Hikokichi Oura; Hiroshi Kashiwagi; Gen-ichiro Nonaka; Itsuo Nishioka Subtotally nephrectomized rats were found to have decreased activities of superoxide dismutase (SOD) and catalase, and spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) showed that the amount...

...Takako Yokozawa; Hikokichi Oura; Kazuharu Ienaga; Ko Nakamura Creatinine (Cr), creatol and methylguanidine (MG), which accumulate in the body with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine...

...Takako Yokozawa; Hikokichi Oura; Tae Woong Lee; Gen-ichiro Nonaka; Itsuo Nishioka Magnesium lithospermate B and adenine were given simultaneously to rats p.o. in order to investigate their renal effects. In rats given magnesium lithospermate B at a dose of 5 mg/kg body weight/day for 12 or 24 days...

...Martin Magnusson; Hans Sjöström; Ove Noren; Nils-Georg Asp; Sverker Eneström; Torsten Denneberg Acute uremia was induced in rats with temporary clamping of the left renal pedicle and contralateral nephrectomy. Jejunal peptidase activities (aminopeptidase N, dipeptidyl peptidase IV...

...Takako Yokozawa; Naoki Fujitsuka; Hikokichi Oura Each of creatinine (Cr), guanidinoacetic acid (GAA) and arginine (Arg) was administered intraperitoneally to rats with renal failure, and the levels of methylguanidine (MG) in the serum, liver, kidney, muscle and urine were determined at certain...

...Takako Yokozawa; Naoki Fujitsuka; Hikokichi Oura Creatinine (Cr) was administered intraperitoneally to both normal rats and those given adenine, and time-course changes in methylguanidine (MG) production from Cr were compared. In rats with renal failure, the accumulation of MG in the body increased...

...Pedro A. Jose; Robert R. Holloway; Todd W. Campbell; Gilbert M. Eisner Dopamine blockade with the dopamine-l/dopamine-2 antagonist cis-flupenthixol (CF) attenuates sodium excretion associated with saline loading in both innervated and denervated kidneys of the rat. Blockade of adrenal dopamine-2...

...P.I. Konrad; B.S. Husberg Isogeneic BN rats were made uremic by subtotal renal resections. After different periods of uremia the possibility of an immunodeficiency was evaluated by (WF×BN) F 1 →BN heterotopic heart transplantations. A prolongation of transplant survival was found...

... on the lipid metabolism of rats with experimental chronic renal failure as compared to normal rats. Three groups of rats were studied: the first had induced chronic uremia, the second was sham-operated and pair-fed with the first, and the third was sham-operated and fed ad libitum. Serum triglycerides were...

...R.C.J. Ribeiro; F.A.R. Neves; R.H. Albuquerque; J.G. Dórea; J.G. Martinelli; A. da Costa e Silva Two groups of adult male rats were used. One group was sham-operated, while the other group had about 70–80% of the left kidney tissue surgically excised and a total right nephrectomy performed 10 days...

...G. Sterner; T. Lindberg; N.-G. Asp; T. Denneberg; A. Wennberg Small intestinal dipeptidases (substrate: glycyl- L -leucine, L -methionyl- L -methionine, and L -alanyl- L -proline) were determined in uraemic and sham-operated rats given normal protein diet (24%), low protein diet (6%), and total...

...Toshikazu Saito; Yoshiko Akita The effects of sera from uninephrectomized rats or sham-operated rats on the facilitation of 3 H-thymidine incorporation into the cells were examined in the primary monolayer culture of rat renal cortical cells. At serum concentrations ranging from 0.25 to 5.0...

...A. da Costa e Suva; R.C.J. Ribeiro; R.H. Albuquerque; P.S.S. Beraldo; F.A.R. Neves; J.G. Martinelli; G.P. Campos Two groups of rats, one with surgically induced chronic renal failure and a sham-operated group were used. 10 weeks after surgery the animals were individually mated for 15 days...

...F. Gregoire Rats were injected with various amounts of bovine albumin (0.5,1.0 and 1.75 g/24 h), inducing thereby proteinuria ranging from 100 to 400 mg/24 h. The glomerular oxygen uptake, dry weight and glucose-6-phosphate dehydrogenase (G-6-PDH) activity were measured on the 4th day...

...Jaime S. Carvalho; Douglas M. Landwehr; Donald E. Oken Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg body weight blood or subcutaneous administration of 500 µg/kg body weight isoproterenol were measured in control rats and animals recovering...

...Bruce L. Thomas; Glenn C. Faith Renal tubular necrosis was observed following intramuscular injections of cephalothin into rats. Lesions were consistently produced with 5.0 g/kg and were maximal in severity at the 2nd and 3rd days following injection. Renal tubular necrosis following cephalothin...

...A. Costa e Silva; R.H. Albuquerque; J.P. Santana The authors utilized two groups of adult male rats to study the effect of chronic-uremic toxemia on the synthesis of thyroid hormones. The control group was sham operated, while the other group had about 70–80% of the left kidney tissue surgically...

...May Y. Liang; Milton Toporek; Bernard Schepartz The kinetics of bromosulfophthalein clearance from plasma, secretion into bile, and, by difference, storage in hepatic cells, were determined, using normal livers and blood from normal rats in the isolated perfused rat liver system. Two suspected...