... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 Cystinuria Nephrolithiasis Immunology Proximal tubule Atopia Inflammation Cystinuria (CYS) is a rare genetic disorder involving the transport of dibasic...

...Yuji Oe; Volker Vallon Background: In acute kidney injury (AKI), proximal tubules are a primary site of injury, resulting in significant alterations in amino acid transport and metabolism. However, little is known about the therapeutic potential of targeting amino acid transporters. Here, we...

... role in permitting initiation of repair mechanisms and proliferation [ 7 ]. However, the remainder of this review will focus on the roles of KLF6 and KLF15 in control of PT metabolism. NIH Acute kidney injury Metabolism Proximal tubule Transcription factors © 2023 S. Karger...

...Sandra Hummelgaard; Kathrin Weyer The kidney proximal tubule is a major target tissue of the renin-angiotensin system (RAS). Megalin is an endocytic multiligand receptor abundantly expressed in the proximal tubule where it drives reabsorption of peptides and proteins from the glomerular...

...Sian E. Piret; Sandeep K. Mallipattu The proximal tubule (PT) is a major target in acute kidney injury (AKI), leading to profound changes in PT cell biology. Amongst the genes with early and robust changes in expression are many transcription factors (TFs), which themselves account for other...

... proteinuric obese subjects compared with controls. However, a protein meal led to a delayed glomerular hyperfiltration in obese patients compared with controls. Conclusion: This study shows that obese patients, in the absence of significant comorbidities, have a normal proximal tubule Na + absorption at basal...

..., instructions or products referred to in the content or advertisements. Telomerase T Telomerase C Renal ischemia reperfusion  Autophagy Proximal tubule Mammalian target of rapamycin Senescence p16 Acute kidney injury (AKI) frequently results from tubule injury by acute ischemic or toxic...

... in RT G and increases in UGE. Because determination of RT G is not influenced by the filtered glucose load, the calculated RT G values provide a more refined measure of the impact of mutations on renal glucose transport than can be obtained from UGE alone. Glucose Proximal tubule SGLT2...

..., the different lysosomal alteration might reflect differences in their characteristics in vivo. Contrast media Dehydration Kidney Proximal tubule Lysosome Light microscopy Electron microscopy © 1997 S. Karger AG, Basel 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... segments. Southern blot hybridization of PCR products obtained from nephron segments with the CYP4A1 cDNA probe demonstrated strong signals in S2 and S3 segments of the proximal tubule. Immunoblots of nephron segments using a polyclonal anti-rat liver CYP4A1 antibody which cross-reacts with CYP4A2...

... rate, GFR), also appeared to be reduced (11.3 ± 1.6 versus 13.8 + 2.5%, p < 0.05), suggesting compensatory increased proximal reabsorption. In disagreement with the latter, C Li /GFR, alleged to be a measure of fractional sodium and water output from the proximal tubules, was increased (36.2 ± 1.8...

... on the proximal tubule, thick ascending limb and/or inner medullary collecting duct (IMCD). In vitro measurements of 3 H 2 O permeability of perfused IMCD of normal rats showed that vasopressin (50 μU/ ml) added to the bath increased the diffusional water permeability (43.4 ± 4.8 vs. 105.6 ± 9.1×10 -5 cm/s...

..., instructions or products referred to in the content or advertisements. Proximal tubule Glomerulonephritis Acid phosphatase Lysosomes Nephron 29: 68-72 (1981) Intracellular Routes of a Lysosome Marker Enzyme, Acid Phosphatase, in Proximal Convoluted Tubule Cells of Human Kidney in Glomerulonephritis...

...S.I. Ryabov; V.Y. Plotkin; I.J. Freici; A.J. Nevorotin The amount of forming pinocytic (coated) microvesicles on the apical plasma membrane of kidney proximal tubule cells was assessed in kidney biopsies of 10 patients suffering from chronic glomerulonephritis. A significant correlation was found...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Serum phosphate Bicarbonate reabsorption Bicarbonate transport Phosphate transport Proximal tubule Micropuncture...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Microperfusion Peritubular capillaries Proximal tubule Sodium and water reabsorption Acetazolamide Technical Note...

...Klaus O. Stumpe; B. Reinelt; C. Ressel; H. Klein; F. Krück Sodium excretion and proximal tubule function were studied in rats with an aorta-to-vena cava (A-V) fistula using the techniques of micropuncture. 15–28 days after ereation of the fistula, 40% of the rats had developed peripheral edema...

...G. Spear The belief that the swan-neck lesion or the Fanconi syndrome in cystinosis are related to the accumulation of cystine in epithelium of the proximal tubule is questioned. The vulnerability of the visceral glomerular epithelium in cystinosis is emphasized. 27 11 2008 © 1973 S...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Na + /H + exchanger Hypertension Kidney Fusion protein Prostaglandin E 2 Thromboxane B 2 Proximal tubule...

... reabsorption are also supported by results of our previous studies [ 14 ]. Free-form pentosidine is continuously filtered through the glomeruli, reabsorbed in the proximal tubules where it is degraded or modified, and eventually excreted in the urine. The kidney thus plays a key role in the disposal of free...