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Raúl Morales Febles, Domingo Marrero Miranda, Coriolano de la Concepción Cruz Perera, Laura Díaz Martín, Ana Elena Rodríguez-Rodríguez, Amelia Remedios González Martín, Daniel Javier Sánchez Báez, Esteban Porrini
Published Online: 23 August 2023
... the metabolic risk factors and main renal outcomes: renal function loss and albuminuria/proteinuria. This review includes prospective studies and clinical trials. A total of 44 studies were analysed in 1,700 subjects with renal disease (2–5), including patients with renal transplantation. Most studies did...
Nephron (2023) 147 (7): 383–391.
Published Online: 18 July 2023
... renal prognosis. However, some patients can develop proteinuria and progressive kidney dysfunction in the long term. Most patients with TBM are heterozygous for pathogenic variants in genes encoding for both the α3 and α4 chains of collagen IV, a major constituent of GBM. Such variants are responsible...
Lei Zhang, Xiaoyan Peng, Bingbin Zhao, Peng Xia, Yubing Wen, Wei Ye, Xuemei Li, Xuewang Li, Wenling Ye, Hong Cheng, Limeng Chen
Nephron (2023) 147 (9): 531–540.
Published Online: 20 February 2023
...Lei Zhang; Xiaoyan Peng; Bingbin Zhao; Peng Xia; Yubing Wen; Wei Ye; Xuemei Li; Xuewang Li; Wenling Ye; Hong Cheng; Limeng Chen Introduction: Gitelman syndrome (GS) is a rare renal tubular salt-wasting disorder. Besides kidney electrolyte loss, proteinuria and renal dysfunction were also observed...
Nephron (2023) 147 (8): 470–477.
Published Online: 16 January 2023
...Ali Mollataheri; Marzieh Mojbafan; Rozita Hosseini; Nakisa Houman; Mohammad Mousavi; Hasan Otoukesh Introduction: Dent’s disease is an X-linked inherited renal tubular disorder characterized by proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, rickets, and end-stage renal disease...
Ekamol Tantisattamo, Uttam G. Reddy, Hirohito Ichii, Antoney J. Ferrey, Donald C. Dafoe, Nick Ioannou, Jing Xie, Tessa R. Pitman, Emily Hendricks, Natsuki Eguchi, Kamyar Kalantar-Zadeh
Nephron (2022) 146 (2): 220–226.
Published Online: 09 December 2021
... kidney donation. She developed postdonation nonnephrotic range proteinuria and microscopic hematuria. Given the risk of biopsy with a solitary kidney, genetic testing was performed and revealed autosomal dominant Alport syndrome. Our case underscores the utility of genetic testing. Hopefully, future...
Nephron (2022) 146 (1): 45–48.
Published Online: 14 September 2021
... to different disease courses, FD can be divided into classical and nonclassical phenotypes. The nonclassical FD phenotype is always absent of characteristic symptoms, which makes identifying it challenging. This article presents a 49-year-old man with a 10-year history of proteinuria and decreased glomerular...
Nobuhisa Morimoto, Kiyotaka Nagahama, Takayasu Mori, Takuya Fujimaru, Yukio Tsuura, Ayumi Terai, Madoka Tanabe, Megumi Otani, Shingo Shioji, Suguru Hirasawa, Shota Aki, Makoto Aoyagi, Eisei Sohara, Shinichi Uchida, Hiroyuki Tanaka
Nephron (2021) 145 (6): 776–782.
Published Online: 26 August 2021
... thinning of the glomerular basement membrane (GBM) associated with a novel heterozygous variant in the LMX1B gene. A 43-year-old female patient with a previous diagnosis of NPS, referred to our hospital for persistent proteinuria, underwent a renal biopsy, which revealed minor glomerular abnormalities. She...
Paras P. Shah, Tammy M. Brady, Kevin E.C. Meyers, Michelle M. O’Shaughnessy, Keisha L. Gibson, Tarak Srivastava, Jarcy Zee, Daniel Cattran, Katherine R. Tuttle, Crystal Gadegbeku, Dorey Glenn, Vimal Derebail, Abigail Smith, Chia-shi Wang, Brenda W. Gillespie, Markus Bitzer, Christine B. Sethna
Nephron (2021) 145 (3): 245–255.
Published Online: 05 March 2021
..., data were from 541 participants enrolled in the Nephrotic Syndrome Study Network (NEPTUNE), between 2010 and 2019, at 23 sites across North America. Blood pressure, lipids, and kidney disease outcomes including complete proteinuria remission, kidney failure, and chronic kidney disease progression were...
Marila Gaste Martinez, Vanessa dos Santos Silva, Adriana Polachini do Valle, Rogério Carvalho de Oliveira, Vanessa Burgugi Banin, Newton Key Hokama, Luis Cuadrado Martin
Nephron (2019) 143 (1): 62–67.
Published Online: 19 June 2019
...Marila Gaste Martinez; Vanessa dos Santos Silva; Adriana Polachini do Valle; Rogério Carvalho de Oliveira; Vanessa Burgugi Banin; Newton Key Hokama; Luis Cuadrado Martin Background/Aims: Previous studies reported that fractional clearance of urinary proteins is better than total proteinuria...
Ricardo Silvariño, Pablo Rios, Graciela Baldovinos, María Alejandra Chichet, Nancy Perg, Laura Sola, Gustavo Saona, Nancy De Souza, Verónica Lamadrid, Liliana Gadola
Nephron (2019) 143 (2): 100–107.
Published Online: 14 June 2019
...Ricardo Silvariño; Pablo Rios; Graciela Baldovinos; María Alejandra Chichet; Nancy Perg; Laura Sola; Gustavo Saona; Nancy De Souza; Verónica Lamadrid; Liliana Gadola Introduction: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) reduce proteinuria and slow...
Egemen Cebeci, Iskender Ekinci, Meltem Gursu, Cihan Coskun, Serhat Karadag, Sami Uzun, Ahmet Behlul, Tuba Elif Senel, Rumeyza Kazancioglu, Savas Ozturk
Nephron (2019) 142 (4): 311–319.
Published Online: 22 May 2019
... with proteinuria and renal function in ADPKD. Methods: Fifty-six patients with ADPKD and 28 volunteers were enrolled to study. Podocin, podocalyxin protein levels, and proteinuria were measured in urine. Patients were categorized based on their estimated glomerular filtration rate (eGFR). Results: Patients...
Nephron (2019) 142 (3): 208–215.
Published Online: 28 March 2019
... that might be related to mortality. Results: The prevalence of hematuria alone and in combination with proteinuria was 11.6 and 5.1%, respectively. C-reactive protein was a significant factor associated with the presence of hematuria (OR [95% CI] 1.17 [1.03–1.34], p = 0.0194). The cumulative mortality...
Nephron (2019) 141 (3): 156–165.
Published Online: 17 December 2018
... TaqMan SNP-genotyping-assay. Results: MMP-9 ( Gln 279 Arg) AA-genotype (OR 0.17 [0.04–0.62, p = 0.008]) and the time elapsed since diagnosis of T2D without onset of proteinuria (OR 0.87 [0.79–0.97, p = 0.008]) were found to be independently associated with reduced risk of susceptibility to DN...
Julie Boucquemont, Sylvie Lawson-Ayayi, Claire Rigothier, Fabrice Bonnet, Cécile Proust-Lima, Didier Neau, Carine Greib, Ghada Miremont-Salamé, François Dabis, Michel Dupon, Frédéric-Antoine Dauchy, for ANRS C03 Aquitaine Cohort Study Group
Nephron (2017) 136 (3): 211–220.
Published Online: 26 April 2017
... therapy (ART), human immunodeficiency virus (HIV)-infected patients have a drastically improved prognosis but at the same time they are also more affected by non-HIV related complications, such as chronic kidney disease. The objective of our study was to investigate the effect of proteinuria and tenofovir...
Pietro Anastasio, Davide Viggiano, Miriam Zacchia, Claudia Altobelli, Giovambattista Capasso, Natale Gaspare De Santo
Nephron (2017) 136 (2): 151–157.
Published Online: 23 March 2017
... in obese subjects. Body mass index Proximal tubule Kidney disease Proteinuria Obesity Glomerular filtration rate It is an accepted fact that the glomerular filtration rate (GFR) and renal plasma flow (RPF) are reduced with obesity [ 1 ]. In non-obese subjects (body mass index [BMI] <30...
Paula S. Mantula, Tuula K. Outinen, Jan P.G. Clement, Heini S.A. Huhtala, Ilkka H. Pörsti, Antti Vaheri, Jukka T. Mustonen, Satu M. Mäkelä
Nephron (2017) 136 (3): 193–201.
Published Online: 21 March 2017
... is acute tubulointerstitial nephritis. We examined the type and kinetics of urine protein excretion and prognostic significance of proteinuria for the severity of acute kidney injury (AKI) in acute PUUV infection. Methods: The amount of dipstick albuminuria at hospital admission was analyzed in 205...
Shu Li, Ling Wang, Minfang Zhang, Wenyan Zhou, Wei Fang, Qin Wang, Chaojun Qi, Shan Mou, Xinghua Shao, Zhaohui Ni
Nephron (2017) 135 (2): 87–96.
Published Online: 15 December 2016
.... Demographic data and clinical data at baseline and month 3 of treatment with CP were assessed. Results: The proportion of patients with remission (both CR and PR) was 82.4%, over an average follow-up duration of 15 (10-27.5) months. Fifty-two of them experienced a CR. Baseline proteinuria and the reduction...
Nephron (2016) 133 (4): 270–278.
Published Online: 22 July 2016
... in GEC can reduce proteinuria induced by puromycin aminonucleoside (PAN) or in anti-glomerular basement membrane (GBM) antibody (Ab)-mediated glomerulonephritis (GN). Methods: HO-1 overexpression in GEC (GEC HO-1 ) of Sprague-Dawley rats was achieved by targeting a FLAG-human (h) HO-1 using transposon...
Maria-Paz Marco Mayayo, Montserrat Martinez Alonso, Jose M. Valdivielso Revilla, Elvira Fernández-Giráldez
Nephron (2016) 133 (4): 232–238.
Published Online: 20 July 2016
...Maria-Paz Marco Mayayo; Montserrat Martinez Alonso; Jose M. Valdivielso Revilla; Elvira Fernández-Giráldez Background: The quantification of proteinuria with the protein to creatinine ratio (PCR) is influenced by the excretion of creatinine, which, in turn, varies according to muscle mass and hence...
Benedicte Eneman, Lambertus van den Heuvel, Kathleen Freson, Chris Van Geet, Brigith Willemsen, Henry Dijkman, Elena Levtchenko
Nephron (2016) 132 (4): 301–311.
Published Online: 07 April 2016
... receptor was tested in HK-2 cells, measuring cyclic adenosine monophosphate levels after PACAP exposure. The influence of PACAP on cell viability and transforming growth factor-β1 (TGF-β1) expression was measured in HK-2 cells exposed to albumin, mimicking proteinuria related damage. Results: VPAC1...