... used as controls. All candidate variants were assessed in silico. Results: The clinical manifestations of patients with IgA-T were hematuria, proteinuria, and renal insufficiency. Histopathological analysis showed mild mesangial hyperplasia, focal segmental glomerulosclerosis, podocyte activation...

... proteins targeted in several other types of primary and secondary MN are proteins whose expression is shared by podocytes and neurons. While complement-mediated podocyte damage represents a well-established paradigm in the pathogenesis of MN, interference with the normal functions of these shared proteins...

...Qian Zhang; Xinxin Jiang; Donghai Wen; Yulin Zhang; Jianping Mao; Li Ni; Jing Chen Background: The change of podocyte morphology is a pathologic feature of chronic kidney disease. Several studies have suggested that vitamin D plays a role in the protection of podocytes, but the underlying mechanism...

... in ADPKD may affect the further course of disease in which it may hypothetically be secondary to the result of glomerular involvement causing podocyte injury. Our aim was to compare urinary excretion of podocin and podocalyxin, which are biomarkers of podocyte injury, and to assess their relationship...

... collected from 1 to 25 weeks after CsA injection. Glomerular expression of CD44 was immunohistochemically evaluated, as were markers for glomerular podocytes and PECs. Results: Glomerular CD44 expression occurred from 2 weeks after CsA injection and gradually increased in the CsA group. CD44-positive...

... that leaves mouse cells relatively unaffected, but upon binding to hDTR it ultimately leads to cell death. We used a podocyte-specific hDTR expressing (Pod-DTR) mouse to assess the anti-permeability and cyto-protective effects of the splice isoform vascular endothelial growth factor (VEGF-A 165 b). Methods...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2017 Fabry’s disease Kidney biopsy Podocyte Genetic diseases Kidney histology Anderson-Fabry disease Interstitial fibrosis Glomerulus Hemodialysis...

...) and a blinded comparison was done with a reference histologic method. Results: Significant correlations ( p < 0.001) were found between the stereomicroscopic scoring of glomerular characteristic white storage material and the amount of podocyte globotriaosylceramide (Gb3) deposits scored by standardized...

...Xiang Liu; Yun Liu; Yang Yang; Jiadai Xu; Deshu Dai; Chao Yan; Xiangyang Li; Renxian Tang; Chen Yu; Hongqi Ren Background: Oxidative stress is a leading cause of puromycin aminonucleoside (PAN)-induced nephrosis. As the inhibition of oxidative stress may improve injury of podocyte, we aimed...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Podocyte Proteinuria...

... pathogenesis. B7-1 (CD80), normally expressed by antigen-presenting cells, is one of the major co-stimulators of T-cell activation through the binding with its counter-receptors CD28 and cytotoxic T-lymphocyte antigen-4. Unexpectedly, B7-1 induction was described at the podocyte level in patients affected...

... roles of plexins. Differentiation 2012;83:77-91. 4. Reidy K, Tufro A: Semaphorins in kidney development and disease: modulators of ureteric bud branching, vascular morphogenesis, and podocyte-endothelial crosstalk. Pediatr Nephrol 2011;26:1407-1412. 5. Guan F, Villegas G, Teichman J, Mundel P...

... reporter systems using a putative parietal epithelial cell (PEC) promoter have led to the suggestion that podocyte progenitor cells were located in Bowman's capsule of mice [ 30 ]. This promoter also led to the labeling of proximal tubular cells (PTCs), which had concomitantly been identified due...

...Gabriella Casalena; Erwin Bottinger; Ilse Daehn Background/Aims: In podocytes, the overexpression of TGFβ ligands and receptors during glomerulosclerosis could be a causal factor for injury induction and perpetuation in glomerular tufts. Mitochondrial dysfunction and oxidative stress are emerging...

...Eirini Lioudaki; Konstantinos G. Stylianou; Ioannis Petrakis; Georgios Kokologiannakis; Andreas Passam; Dimitri P. Mikhailidis; Eugene K. Daphnis; Emmanouil S. Ganotakis Background: Podocyte injury plays a crucial role in the pathogenesis and progression of diabetic nephropathy (DN). We...

.../kg single intravenous injection). We also tested immortalized murine podocytes to examine the effects on podocyte apoptosis. Results: Mice with ADR-induced nephropathy developed progressive albuminuria and glomerulosclerosis within 30 days accompanied by decreased expression of slit diaphragm (SD...

... were re-biopsied after three or five years. Results: In all patients, significant GL3-accumulation was found in several types of kidney cells with high amounts of GL3 in the podocytes. Segmental podocyte foot process effacement was shown in all but two patients; no effacement was seen neither...

... of age with vehicle or bindarit. Sprague-Dawley rats served as control. For in vitro studies, murine podocytes were exposed to albumin with or without bindarit. Results: MCP-1 mRNA was upregulated in the kidney of PCK rats and reduced by bindarit. Treatment limited overexpression of MCP-1 protein...

... glomerular epithelial cell (PGEC) only partly in a normal rat kidney section, reacted to PGEC more extensively at day 3 and also with cellular crescents at day 7. During the course of this model the podocytes lost their characteristic to be stained by anti-podocalyxcin Ab and obtained a new marker...