... to the influence of substances or inflammatory cytokines that should be cleared in time. In addition, oxidative stress, the gut, and the gut microbiota are also influencing factors. Key Messages: In this review, we highlight the mechanisms involved in the development of CI in CKD. [email protected]...

...Haihua Guo; Wibke Bechtel-Walz Background: Autophagy, as an indispensable metabolism, plays pivotal roles in maintaining intracellular homeostasis. Nutritional stress, amino acid deficiency, oxidative stress, and hypoxia can trigger its initiation. Oxidative stress in the kidney activates essential...

... assay verified Nrf2 as a direct target of miR-155-5p. Our further results indicated anti-miR-155-5p could suppress kidney oxidative stress and inflammation, also supporting Nrf2 was the direct target of miR-155-5p. Finally, we also found miR-155-5p did not increase in serum but significantly increased...

..., and acute kidney injury (AKI) is one of the most serious off-target toxicities [ 1 ]. Currently, there is no FDA-approved drug for prevention or treatment of AKI. The pathophysiology of cisplatin-induced AKI is complex and involves multiple pathways that includes but not limited to oxidative stress-driven...

.... Pathway analysis extracted molecular pathways related to oxidative stress, inflammation, and cell adhesion. As the levels of mRNAs relevant to the NADPH oxidase 2 (NOX2) pathway were prominently (4 genes >5-fold) increased in pcy mice, we further analyzed the molecules related to this pathway. A time...

.... CaD may exert its protective effect through alleviating oxidative stress, apoptosis, and inflammation, as well as modulating some signaling pathways in the kidney. Burn Acute kidney injury Calcium dobesilate Reactive oxygen species Inflammation Oxidative stress Severe trauma...

.... Taurine Diabetic nephropathy Mitochondria Podocytes TRPC6 Oxidative stress Diabetic kidney disease (DKD) is one of the most serious complications of diabetes and has been considered to be the leading cause of end-stage renal disease in the world [ 1, 2 ]. Currently, the injury of podocytes...

.... Anti-oxidants Childhood Nephrotic syndrome Oxidative stress Thiol/disulphide homeostasis Despite being studied extensively, the pathogenesis of nephrotic syndrome (NS) remains unclear, although immunological and genetic mechanisms are suspected [ 1-3 ]. Oxidative stress plays an important...

...Anna Levin; Deepika Nair; Abdul Rashid Qureshi; Peter Bárány; Olof Heimburger; Björn Anderstam; Peter Stenvinkel; Annette Bruchfeld; Johanna S. Ungerstedt Background: Inflammation and oxidative stress play important roles in the pathogenesis and progression of chronic kidney disease (CKD...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Iron Oxidative stress Acute kidney injury Hepcidin Ferroptosis Hepcidin induces iron sequestration primarily in macrophages by downregulating ferroportin expression and cellular...

...Piotr Kuczera; Marcin Adamczak; Grzegorz Machnik; Boguslaw Okopien; Andrzej Wiecek Background/Aims: Oxidative stress is one of the leading factors contributing to increased mortality in patients with chronic kidney disease (CKD) and secondary hyperparathyroidism (sHPT). Cinacalcet is now commonly...

...Ana M. Pena; Shali Chen; Biao Feng; Lu Cai; Xiaokun Li; Guang Liang; Subrata Chakrabarti Background/Aims: Oxidative stress (OS) contributes to all chronic diabetic complications, including diabetic nephropathy (DN). Acidic fibroblast growth factor (aFGF) has shown to confer protection from OS...

... of renal function and arteriolopathy, tubulointerstitial fibrosis, inflammation, and apoptosis. We evaluated oxidative stress as a protective mechanism via xanthine oxidase (XO) activity, and as a marker of oxidative stress (via evaluation of levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxy-2...

...Jun Zhang; Peter A. McCullough Hypoxia, reactive oxygen species (ROS) and oxidative stress contribute to contrast-induced acute kidney injury (CI-AKI) and ischemic reperfusion injury (IRI) in the kidney and heart. Imbalance between the increased formation of ROS by hypoxia in the cardiac and renal...

... and is nowadays the leading cause of end-stage renal disease (ESRD). Among several factors involved in the development and progression of DKD are also inflammation and oxidative stress. Unfortunately, there is a paucity of sensitive and specific biomarkers for the early prediction of patients who will develop DKD...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Na/K-ATPase NADPH oxidase Oxidative stress Unilateral ureteral obstruction...

...Jaime Uribarri; John Cijiang He Increasing evidence in the literature suggests an important role for advanced glycation end products (AGEs) in the generation of a state of increased oxidative stress and chronic subclinical inflammation, which underlies most modern chronic diseases, including...

... to assess the extent of oxidative stress and renal fibrosis including superoxide level, nitrotyrosine staining, TGF-β1, NLRP3 and collagen IV expression. Fluorescent-labelled TXNIP DNAzyme was localized to tubulo-epithelial cells, but was not identified in glomeruli or endothelial cells. Elevated renal...

... and Z’/X’ values which might be a kind of indices for oxygen stress (oxidative stress) increased in proportion to the increased severity of CRF in such patients. Although its meaning and interpretation are still debatable, diabetic CRF patients had a significantly higher α’ value (2.2) than that (0.89...

...Justin Westhuyzen; Catherine E. Adams; Simon J. Fleming The evidence for oxidative stress during haemodialysis is controversial. We therefore examined markers of oxidative stress and lipid peroxidation using an in vitro dialysis circuit. A unit of fresh blood (500 ml) therapeutically removed from...