...Abdelaziz M. Hussein; Hussein F. Sakr; Faris Q. Alenzi Background: It has been documented that remote limb ischemic preconditioning (rIPC) protect kidneys against renal ischemia/reperfusion (I/R). We hypothesized that osteopontin (OPN), transforming growth factor beta (TGF-β), apoptotic proteins...

...Tsuyoshi Sakai; Hisako Tanaka; Takuji Shirasawa In order to clarify cellular responses in dilated renal tubules in the acute and chronic phase of ureteral obstruction, we investigated the expression of proliferating cell nuclear antigen and osteopontin (OPN) in unilateral ureteral obstruction (UUO...

... The possibility of more than one urinary protein being simultaneously associated with calcium oxalate (CaOx) crystallization in vivo was investigated by examining the localization of Tamm-Horsfall protein (THP) and osteopontin (Opn) in a rat model of nephrolithiasis. CaOx crystal deposits were...

..., and interstitial inflammation and fibrosis. AST-120 significantly reduced renal expression of intercellular adhesion molecule (ICAM)-1, osteopontin, monocyte chemotactic protein (MCP)-1, and transforming growth factor (TGF)-β1, as well as clusterin. All the five molecules were expressed mainly in tubular cells...

... was designed to evaluate the inhibitory effects of colchicine on osteopontin (OPN) expression and the macrophage accumulation in chronic cyclosporine (CsA) nephrotoxicity in rats. Methods: Male adult Sprague-Dawley rats on a low salt diet (LSD, 0.05% sodium) were treated daily with Col (30 µg/kg), CsA (15 mg...

... decreased as compared with the CRF group. Furthermore, the CRF+BK group showed a smaller interstitial fibrosis area and a lower renal osteopontin expression than the CRF+B group. Conclusion: Combination therapy of benazepril and AST-120 is more effective than benazepril alone in retarding the progression...

...Kosaku Nitta; Tsutomu Ishizuka; Shigeru Horita; Tetsuo Hayashi; Akiko Ajiro; Keiko Uchida; Kazuho Honda; Takashi Oba; Akira Kawashima; Wako Yumura; Takashi Kabaya; Takashi Akiba; Hiroshi Nihei Background: Vascular calcification often occurs in patients with uremia. As osteopontin (OPN) is not only...

...Nami Sano; Kozo Kitazawa; Tetsuzo Sugisaki An important function of CD44 is to act as a cellular receptor for hyaluronic acid and osteopontin. Cell-matrix interactions mediated by the CD44/hyaluronic acid receptor-ligand pair are involved in the regulation of leukocyte migration and activation...

... of mizoribine on the infiltration of interstitial macrophages and T lymphocytes and the interstitial volume in UUO-treated kidneys. Furthermore, we investigated the expression of osteopontin (OPN), known to be a chemoattractant protein for macrophages, in the renal cortex. In rats with UUO, the interstitial...

... on the matrix, we investigated its effect on the expression of osteopontin (OPN), which we previously identified as an important stone matrix protein. Methods: Control rats were not treated. Rats of the stone group were given ethylene glycol (EG) and vitamin D 3 , while the allopurinol groups (low-dose group...