.... The primary outcome is a composite of dialysis dependence or all-cause mortality at day 90. Conclusion: The SCD is a cell-directed extracorporeal therapy that targets and deactivates pro-inflammatory neutrophils and monocytes, with evidence of efficacy across a variety of critically ill patient populations...

..., instructions or products referred to in the content or advertisements. Immune cell infiltration Neutrophils Monocytes Tubular injury Sterile inflammation Innate immunity National Institutes of Health (NIH) 10.13039/100000002 The kidneys maintain systemic water, salt, and pH...

... proliferation and matrix expansion, and the factors that lead to healing or scarring. Special emphasis is placed on the cytokines interleukin 1 beta and tumor necrosis factor alpha, which are proinflammatory cytokines that potentiate neutrophil-and monocyte-mediated glomerular injury, and on the growth factors...

...-nephritic patients on the signal transduction of human neutrophils. Heat-aggregated forms and monomers of IgA and IgG were prepared from sera of 11 IgA-nephritic patients and 11 healthy controls. Signal transduction was studied by measuring the inositol triphosphate (IP3) production in neutrophils incubated...

...Giovanni Carulli; Giuliano Barsotti; Adamasco Cupisti; Sistina Minnucci; Maria Luisa Gianfaldoni; Barbara Agostini; Fabio Ambrogi Isolated resting platelets are able to limit neutrophil activation and then can control the tissue-damaging potential of activated neutrophils. In the present study...

...Yutaka Yaguchi; Yasuhiko Tomino; Teruyo Ozaki; Ko Okumura; Fujiro Sendo; Hikaru Koide The effects of the reduction of neutrophils in glomeruli on the improvement of proteinuria and glomerular injuries were determined in the first (heterologous) phase of Masugi (nephrotoxic) nephritis. Male (6-week...

... the pathophysiologic effect of IgA and IgG isolated from IgA nephritic patients on the signal transduction and oxidative metabolism of human neutrophils. Heat-aggregated forms, monomers, and F(ab’) 2 fragments of IgA and IgG were prepared from sera of 11 IgA nephritic patients and 11 healthy controls. Signal...

...Walter Zidek; Klaus H. Neumann In suspensions of permeabilized human neutrophils, the free Ca 2+ concentration was measured to test the effects of ciclosporin. Free Ca 2+ concentration was measured with a Ca 2+ -selective electrode. Ciclosporin (500 ng/ml) induced a transient increase in free Ca 2...

...) decreasing the synthesis of IgA-IC; (ii) limiting the mesangial uptake of IgA-IC; (iii) antagonizing the effect of PDGF and TGF-β to reduce mesangial proliferation and glomerulosclerosis; and (iv) reducing the noxious glomerular injury due to infiltrating neutrophils. The effective treatment of IgAN requires...

...Momoyo Omata; Chieko Higuchi; Reiko Demura; Tsutomu Sanaka; Hiroshi Nihei Background/Aim: Transient leukopenia during hemodialysis due to neutrophil activation is attributed to bioincompatibility of the dailysis membrane, but the mechanism remains unclear. We studied the mechanism of neutrophilic...