... trial Nephrotoxicity Liver toxicity Heart failure Alport syndrome (AS) is a hereditary, progressive chronic kidney disease with X-linked, autosomal, and digenic patterns of transmission. Persistent proteinuria and hematuria are hallmarks of the disease, along with neurosensory hearing loss...

..., Phase 3 trial . Lancet Oncol . 2018 Nov ; 19 ( 11 ): 1437 – 48 . 10.1016/s1470-2045(18)30739-3 IgA nephropathy Trifluridine/Tipiracil Nephrotoxicity IgA nephropathy (NIgA) is usually a primary glomerular disease, but NIgA is sometimes associated with various medical conditions...

... evaluated the effect of antiretroviral drugs (ARVs) that elicit a benign increase in serum-creatinine on the performance of these equations. In order to evaluate, whether treatment with drugs that elicit benign increase in serum-creatinine and potentially nephrotoxic drugs are associated with a poorer...

... showed dose-dependent proximal tubular damage and polyuria in the AA-I- and AL-I-treated groups, and the nephrotoxicity of AL-I was higher than that of AA-I. The expression of renal AQP1, AQP2 and AQP4, but not AQP6 were significantly inhibited by AA-I and AL-I. Comparison of the inhibition potencies...

... concentration in the murine kidney cortical slices after the treatment with cisplatin. These results indicate that ulinastatin has a protective effect against cisplatin nephrotoxicity, and its prevention of the increase in lysosomal fragility is a probable mechanism involved in the renal protection. 12 10...

...Jonathan Purnell; Donald C. Houghton; George A. Porter; William M. Bennett Potassium and magnesium deficiency have been reported as risk factors for experimental gentamicin nephrotoxicity. Amiloride, a potassium-sparing diuretic, also leads to increased renal magnesium reabsorption. Amiloride, 2 mg...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ulinastatin LLC-PK 1 cells Nephrotoxicity Antimycin A Gentamicin Cisplatin...

... Silbernagl Department of Physiology, University of Wurzburg, Germany Original Paper Nephron 1997;76:472-476 Accepted: October 29, 1996 Derangement of pH Homeostasis in the Renal Papilla: Ochratoxin A Increases pH in Vasa recta Blood Key Words Ochratoxin A Nephrotoxicity pH homeostasis pH microelectrode Vasa...

..., instructions or products referred to in the content or advertisements. Nephrotoxicity Tumor necrosis factor-α Isolated limb perfusion β 2 -Microglobulin Sepsis syndrome NEPHRON Original Paper Nephron 1997;76:146-152 Accepted: October 17. 1997 Jan II. Zwavelinga Harald J. Hoekstrab John K. Maringa...

...Osama A. Badary; Mahmoud N. Nagi; Hussein A. Al-Sawaf; Mohammed Al-Harbi; Abdullah M. Al-Bekairi The effect of L -histidinol (LHL) on the acute nephrotoxicity produced by cisplatin (CDDP; 6 mg/kg, i.v.) was investigated in the rat. Intraperitoneal administration of LHL (100 mg/kg × 5 doses, 2 h...

... The nephrotoxicity of low-dose methotrexate (MTX) and the rescue effect of leucovorin were studied by electron-microscopic examination of the kidney of guinea pigs. One group received MTX as a single weekly dose of 10 mg/kg, i.p.; a second group received a similar dose divided into three equal...

... to in the content or advertisements. Gentamicin Nephrotoxicity Free radicals Vitamin E Vitamin C NEPHRON Original Paper Nephron 1996;72:269-274 Mustafa Kavutcu8 Orhan Canbolata Serdar Öztürka Ekmel Okay c Satümis Ululepea Cenül Ekincib Ismail Ilakki Gökhuna re/-Duraka Departments of a Biochemistry...

... Pharmacokinetics Nephrotoxicity NEPHRON Original Paper Nephron 1996;72:212-217 K.J. Berg3 B. Lundbyd V. Reinton6 K.P. Nordala A'. Rootweltb II-J. Smithc a Nephrology Section, Medical Department B. b Department of Clinical Chemistry, and c Department of Radiology, Rikshospitalet. The National Hospital, Oslo, d...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Uranium Nephrotoxicity Acute renal failure NEPHRON Case Report...

... in gentamicin nephrotoxicity. 30 09 1994 18 12 2008 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...

... nephrotoxicity is similarly influenced. This study evaluated whether the acute nephrotoxic response to amphotericin B is potassium sensitive. Potassium-depleted and control rats were subjected to an acute intravenous infusion of either amphotericin B (AmB-K; AmB, n = 10 in each) or its vehicle (V-K, V; n = 6...

... is consistent with the development of nephrotoxicity (NT). Urine volume (V) did not change and proteinuria (PU) was not provoked. These changes were associated with significantly diminished ratios of urinary PGE 2 /TXB 2 and 6kPGF 1α /TXB 2 excretions. Light-microscopic (LM) sections of rat kidneys showed...

... and decline of PAH uptake was found, suggesting that lipid peroxidation may only in part participate in cisplatin-induced alterations of PAH uptake. Nephrotoxicity Cisplatin Renal p -aminohippurate uptake Lipid peroxidation Glutathione N-Acetylcysteine Deferoxamine Gingko biloba extract...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nephrotoxicity Albuminuria Transferrinuria Enzymuria Retinol-binding protein Silicon Silica Quarry work Original Paper Nephron 1995;70:438-442 P. Hotz J. Gonzalez...

..., Mg metabolism and ciclosporine (Ci)-associated nephrotoxicity are interrelated. Food with 100 ppm Mg (lMg) or 1,000 ppm Mg (stMg) or 10,000 ppm Mg (rMg), Ci 20 mg/kg body weight daily or olive oil were applied for 3 months (n = 10/group). Mg concentrations in various compartments were measured...