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Keywords: Mitochondria
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Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2022) 146 (3): 253–258.
Published Online: 09 December 2021
... or indirectly preserve mitochondrial integrity and function have been shown to mitigate IRI-linked AKI in preclinical models. Interestingly, isolated mitochondria have been recently shown to be taken up by various mammalian cells resulting in incorporation of transplanted mitochondria into the endogenous...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2022) 146 (3): 229–233.
Published Online: 25 November 2021
... in mitochondria. Importantly, mitochondrial function plays an important role in induction and recovery of AKI. Mechanisms that regulate thermoneutrality include uncoupling proteins (UCPs) and one of its upstream regulators peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). PGC-1α has been...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2019) 143 (3): 158–161.
Published Online: 26 June 2019
... could therefore serve the dual purpose of reducing inflammation as well as maintaining tubular cell survival during AKI. Acute kidney injury Adenosine ATP Mitochondria Pannexins Purinergic signaling Pharmacological inhibition or genetic knockout of Panx1 has been shown to improve...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2018) 138 (4): 303–309.
Published Online: 21 December 2017
... of mitochondrial injury and PGC1α expression renal allograft biopsies from patients with DGF at a single center and correlated these with DGF outcomes. Delayed graft function Kidney transplantation Acute kidney injury Mitochondria National Institutes of Health (NIH) 10.13039/100000002...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2017) 137 (4): 253–255.
Published Online: 08 June 2017
.... This fundamental role of mitochondria in renal health may become an “Achilles heel” under duress. Acute kidney injury (AKI) related to each major class of stressor - inflammation, ischemia, and toxins - exhibits early and prominent mitochondrial injury. The mitochondrial biogenesis regulator, PPARγ-coactivator-1α...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2017) 135 (1): 77–86.
Published Online: 24 September 2016
...: This study showed that PTs are more sensitive to apoptosis than DTs during rat renal development, even though both tubule segments contain a large number of mitochondria. Furthermore, Cyt-c-mediated mitochondrial apoptosis-related proteins play an important role in PTs during the early postnatal kidney...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2016) 134 (4): 253–271.
Published Online: 17 August 2016
...). Treatment with high-dose SalB significantly ameliorated the increase in the expression of ROS and revised the structure of mitochondria. The percentage of apoptotic cells was decreased compared with the PAN group after SPE, SalB, RA, and TAC treatment for 24 h (p < 0.05). Conclusion: These findings...
Journal Articles
Journal: Nephron
Nephron (2016) 134 (1): 14–19.
Published Online: 01 July 2016
...Luca Perico; Marina Morigi; Ariela Benigni Mitochondria are dynamic organelles whose functions are tightly regulated at multiple levels to maintain proper cellular homeostasis. Mitochondrial Sirtuin 3 (SIRT3), which belongs to an evolutionary conserved family of NAD + -dependent deacetylases...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2016) 134 (3): 141–144.
Published Online: 16 June 2016
... in AKI remain unclear, cardiac mitochondria injury could be a novel candidate of drug targets against high mortality in severe AKI. kdoi-tky@umin.ac.jp 17 02 2016 21 05 2016 16 6 2016 © 2016 S. Karger AG, Basel 2016 Copyright / Drug Dosage / Disclaimer Copyright: All...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1997) 76 (3): 249–253.
Published Online: 23 December 2008
.... Mitochondria Mitochondrial genome Mitochondrial nephropathy Tubulointerstitial nephritis NEPHRON Review Nephron 1997;76:249-253 M. Buemi3 A. Allegroa A. Rotigd M. C. Gublerb C. Aloisi3 F. Corica3 G. Pettinato3 N. Frisina3 P. Niaudetc a Chair of Nephrology. Department of Internal Medicine, Messina...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1991) 57 (3): 349–354.
Published Online: 11 December 2008
... to in the content or advertisements. Germanium dioxide Nephrotoxicity, dose-dependent Tubule, distal Granule, dense Electron-dense inclusion Mitochondria Nephron 1991;57:349-354 t 1991 S. Karger AG, Basel 0028-2766/91/0573-0349S2.75/0 Dose Dependency of Germanium-Dioxide-Induced Nephrotoxicity in Rats...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1990) 54 (1): 53–60.
Published Online: 10 December 2008
... manifestations. Renal biopsy specimens revealed the tubular epithelial cell degeneration containing hematoxylin-positive fine granules on light microscopy, and electron-dense inclusions in the swollen mitochondria on electron microscopy. These findings localized mainly in distal segment of the tubules...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1987) 47 (1): 66–69.
Published Online: 05 December 2008
... of lysosomes, osmiophilic granular material inside the lysosomes, vacuolisation of organelles and mitochondrial damage of varying degree. No cystic changes were found. Aluminum Acquired cystic kidney disease Mitochondria Renal failure © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1985) 41 (4): 354–358.
Published Online: 04 December 2008
...Andrew J. Adler; Geoffrey M. Berlyne The exchange of calcium between serum, cerebrum and cerebral mitochondria was studied in chronically uremic rats. Chemical and radiocalcium assays were performed at periods from 1 to 48 h following intracardiac injection of 45 Ca. The disappearance of 45 Ca from...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1978) 21 (3): 170–176.
Published Online: 02 December 2008
...Barry B. Kirschbaum Incorporation of 14 C-labeled leucine and mannose were used as indices of protein and glycoprotein synthesis by isolated rat kidney mitochondria. Uninephrectomy, certain salts including NaCl and heavy metals, detergents such as digitonin and lysophosphatidylcholine, and various...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1979) 24 (6): 297–301.
Published Online: 02 December 2008
... mitochondrial fractions. The results are discussed along with other studies of mitochondria in experimental renal disease. 14 05 1979 2 12 2008 Mitochondria Folate nephropathy Protein synthesis Adenosine triphosphatase © 1979 S. Karger AG, Basel 1979 Copyright / Drug Dosage...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1976) 17 (4): 297–306.
Published Online: 28 November 2008
... of mitochondrial function may benefit from the digitonin pretreatment step. Digitonin Mitochondria Lysosomes Glycosidases 29 05 1975 11 09 1975 28 11 2008 © 1976 S. Karger AG, Basel 1976 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...