... responses occur to restore the normal structure and tissue homeostasis in the kidney. Tolerogenic DCs, M2 macrophages and regulatory T cells modulate the renal immune response by direct cell-cell contact or by humoral mediators, leading to endothelial and renal tubular repair and regeneration. However, when...

... reduced glomerular crescent formation, neutrophils and macrophages compared to wild-type mice, while nephritic BM-TC+ mice developed less glomerular segmental necrosis. IL-17RA expression was required in both BM and TC for maximal systemic interferon-γ expression. Antigen-specific humoral immune responses...

... identified many TUNEL-positive apoptotic cells mainly in the nephrogenic region in the developing mouse and human fetal kidneys. Tissue-fixed macrophages were widely distributed throughout the developing mouse and human fetal kidneys, including the nephrogenic zone. Most of the apoptotic cells...

... was up-regulated in various tubules but not associated with the tubular dilatation. Taken together with its chemoattractant activity for macrophage, OPN may be involved in the interstitial fibrosis as another compensatory mechanism in the chronic phase of ureteral obstruction. Therefore, these results...

... Macrophages seem to play an important role in the development of glomerulosclerosis. In the present study we evaluated the effect of morphine, an active metabolite of heroin, on the migration of monocytes across a filter in a modified Boyden chamber. Morphine-mesangial cell interaction enhanced (p...

... The role of infiltrating macrophages in the pathogenesis of acute rejection was investigated in biopsy specimens obtained from human transplanted kidneys using immunohistochemical methods. Thirty-one allograft tissue specimens obtained from 26 patients were histologically classified into 18...

...Jacek Rozga; Roland Andersson; Uppugunduri Srinivas; Bo Ahrén; Stig Bengmark Phosphatidylcholine (PC) is the predominant constituent of the surface-active material coating peritoneal mesothelium. Its effects on surgically induced adhesion formation and on peritoneal macrophage viability...

...E. Podjarny; M. Rathaus; A. Pomeranz; J. Shapira; J. Bernheim Activation of macrophages and release of mediators that activate the coagulation system characterize proliferative glomerulonephritis. To evaluate the possible role of prostanoids in this process, isolated rat glomeruli (G...

... the expression of such molecules on polymorphonuclear leukocytes (PMN) and assessed them, functionally, on PMN, tissue macrophages and circulating monocytes in 6 HLA-B8-, DR3-negative patients with EMC and glomerulonephritis. The Fc receptors expressed on PMN surface, as estimated by using AB 8.28 monoclonal...

...Jürgen Bommer; Diethard Gemsa; Joachim Kessler; Eberhard Ritz Spleen cell suspensions of 2 dialysis patients with hepatosplenomegaly and pancytopenia were studied in vitro. Spleen cells of a cadaver kidney donor were studied as control. In spleen macrophages of the patients, silicone particles...

...Gavin J. Becker; Wayne W. Hancock; Jennifer L. Stow; Eric F. Glasgow; Robert C. Atkins; Napier M. Thomson Serial renal biopsies for glomerular culture, histochemical staining for β-glucuronidase, electron microscopy (EM) and light microscopy, were used to study macrophage involvement...

... was designed to evaluate the inhibitory effects of colchicine on osteopontin (OPN) expression and the macrophage accumulation in chronic cyclosporine (CsA) nephrotoxicity in rats. Methods: Male adult Sprague-Dawley rats on a low salt diet (LSD, 0.05% sodium) were treated daily with Col (30 µg/kg), CsA (15 mg...

... of cytotoxic T cells (CD8) and macrophages (CD14) in the urine and their presence in crescent formations and necrotic glomerular tufts, thus suggesting that macrophages and CD8 play a central role in the glomerular injury or necrotizing glomerulonephritis [ 6, 7, 8 ]. Leukocytapheresis (LAP) may serve...

...B. Handan Özdemir; Beyhan Demirhan; Yücel Güngen Aim: The purpose of this study was to analyze the role of intraglomerular macrophage infiltration in human renal allografts by examining biopsies from kidney grafts that were dysfunctional after transplantation. Methods: Eighty-three patients (58 men...

.... Biopsy specimens were evaluated for macrophages, proliferating cells, α-actin expression, and type IV collagen deposition in both glomeruli and the tubulointerstitium and the results compared with the current WHO and NIH classifications in relation to the clinical presentation. Results: Patients with WHO...

...Nobuyuki Miyatake; Kenichi Shikata; Hikaru Sugimoto; Masahiko Kushiro; Yasushi Shikata; Saeko Ogawa; Yoshiko Hayashi; Masayuki Miyasaka; Hirofumi Makino Mononuclear cells, primarily macrophages and lymphocytes, infiltrate the renal glomeruli and are involved in the progression of various glomerular...