... Endoplasmic reticulum-mitochondrial interaction Fatty acid metabolism Lipotoxicity Tubular inflammation Organelle stress, which is associated with mitochondrial or ER dysfunction, mediates tubular inflammation and fibrosis, playing a crucial role in the pathogenesis of kidney disease, including AKI...

...Elia Escasany; Adriana Izquierdo-Lahuerta; Gema Medina-Gomez The recent and ongoing worldwide increase in the prevalence of obesity parallels the increase in the incidence of chronic kidney disease (CKD). This association suggests an implication of lipotoxicity in the development of kidney diseases...