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Giulia Villa, Erica Daina, Paolo Brambilla, Sara Gamba, Valentina Fanny Leone, Camillo Carrara, Paola Rizzo, Marina Noris, Giuseppe Remuzzi, Andrea Remuzzi, Anna Caroli
Published Online: 03 November 2023
...Giulia Villa; Erica Daina; Paolo Brambilla; Sara Gamba; Valentina Fanny Leone; Camillo Carrara; Paola Rizzo; Marina Noris; Giuseppe Remuzzi; Andrea Remuzzi; Anna Caroli Introduction: Primary membranoproliferative glomerulonephritis (MPGN) is a rare kidney disease with poor prognosis and no specific...
Published Online: 13 July 2023
...Lenar Yessayan; H. David Humes; Emily C. Scribe; Sai Prasad N. Iyer; Kevin K. Chung Introduction: NEUTRALIZE-AKI is a pivotal study to evaluate the safety and effectiveness of the selective cytopheretic device (SCD) in adult patients with acute kidney injury (AKI) requiring continuous kidney...
Nephron (2023) 147 (1): 52–56.
Published Online: 14 February 2023
... proportional to dataset size at a given hospital, which suggests that hospitals with smaller datasets have significant room for growth with federated learning approaches. Key Messages: This short article provides an overview of federated learning, gives a use case for COVID-19-associated acute kidney injury...
Nephron (2023) 147 (8): 458–464.
Published Online: 17 January 2023
...Roberto F. Nicosia Context: The clinical course of coronavirus disease-19 (COVID-19) can be complicated by acute kidney injury and proteinuria. Kidney cells express receptors for SARS-CoV-2, the virus responsible for COVID-19. Direct infection of the kidney parenchyma by SARS-CoV-2 has been...
Nephron (2023) 147 (3-4): 234–243.
Published Online: 22 July 2022
...Tianxin Yang The (pro)renin receptor (PRR) was originally cloned as a specific single-transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physiopathological processes. Activation of PRR in the kidney causes...
Nephron (2022) 146 (3): 278–281.
Published Online: 14 July 2021
...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Kidney Orphan receptor Olfactory receptor Taste receptor G protein-coupled receptor National Institutes...
Nephron (2021) 145 (6): 604–608.
Published Online: 13 April 2021
...Almudena García-Carrasco; Adriana Izquierdo-Lahuerta; Gema Medina-Gómez There is a strong relationship between the kidney and the heart, where if one of these organs fails, so does the other, in the so-called cardiorenal syndrome (CRS). Besides, there are also interactions with the rest of the body...
Adesewa Oloko, Hari Talreja, Alexandra Davis, Brendan McCormick, Edward Clark, Ayub Akbari, Jennifer Kong, Swapnil Hiremath
Nephron (2020) 144 (4): 176–184.
Published Online: 10 March 2020
..., with the exception of 2 studies [ 21, 25 ]. Imaging Contrast induced Dialysis Kidney Residual renal function Acute kidney injury Iodinated contrast media (ICM) are used in the imaging of vascular structures and organs during radiographic procedures, such as computed tomography (CT...
Nephron (2020) 144 (2): 96–108.
Published Online: 29 October 2019
...Bin Wang; Honglei Guo; Lilu Ling; Jialing Ji; Jianying Niu; Yong Gu Background: Chloroquine (CQ), a classic autophagy inhibitor, is used clinically for malaria prophylaxis and pulmonary hypertension treatment. The adverse effects of CQ on morphological and functional changes in the kidney were...
Nephron (2019) 143 (3): 211–216.
Published Online: 14 June 2019
...Dennis G. Moledina; Chirag R. Parikh Background: Differentiating etiologies of acute kidney injury (AKI) is critical in determining the course of care in clinical practice. For example, acute interstitial nephritis (AIN) requires withdrawal of the offending drug and immunosuppressive therapy, while...
Nephron (2019) 141 (2): 128–132.
Published Online: 14 December 2018
...Benjamin S. Freedman Context: Human kidney organoids are complex structures resembling nephron arrays, which can be derived in a variety of ways. Whether all of these differentiation protocols produce qualitatively similar organoid cell types is not yet clear. Subject of Review: A comparative...
Nephron (2019) 143 (1): 8–11.
Published Online: 25 October 2018
..., implying a higher risk of adverse cardiovascular events. More recently, data related to the possible role of obesity in the risk of kidney disease in adults, independently of diabetes, has started to become more available. In children, the evidence is scarcer, but it has also been acknowledged that obesity...
Maria E. Ougaard, Frederikke E. Sembach, Peter H. Kvist, Morten Tonnesen, Klaus S. Frederiksen, Martin Egfjord, Henrik E. Jensen, Elisabeth D. Galsgaard
Nephron (2018) 140 (3): 218–230.
Published Online: 11 September 2018
...Maria E. Ougaard; Frederikke E. Sembach; Peter H. Kvist; Morten Tonnesen; Klaus S. Frederiksen; Martin Egfjord; Henrik E. Jensen; Elisabeth D. Galsgaard Background/Aims: Murine nephrotoxic nephritis (NTN) is a well-established model resembling chronic kidney disease. Investigating gene expression...
Nephron (2018) 140 (3): 185–193.
Published Online: 11 September 2018
...Mostafa Abdelsalam; Sherouk Salah Eldin Elnagar; Ashraf H. Mohamed; Mona Tawfik; Nagy Sayed Ahmed Aim: Acute kidney injury (AKI) is a major health problem with poor patient prognosis. We evaluated the clinical characteristics, risk factors, associated comorbidities, and outcomes of AKI patients...
Nephron (2017) 137 (4): 253–255.
Published Online: 08 June 2017
...Ali Poyan Mehr; Samir M. Parikh With one of the highest mitochondrial densities in the body, the kidneys consume approximately 10% of total oxygen while constituting 0.5% of body mass. Renal respiration is linear to solute extraction, linking oxidative metabolism directly to tubular function...
Lise Høj Thomsen, Morten Fog-Tonnesen, Lisbeth Nielsen Fink, Jenny Norlin, Amaya García de Vinuesa, Troels Krarup Hansen, Emile de Heer, Peter ten Dijke, Alexander Rosendahl
Nephron (2017) 135 (4): 291–306.
Published Online: 07 January 2017
... and kidney fibrosis. In this study, we extend this to an assessment of transcriptional regulation of the entire TGF-β superfamily in kidneys from diabetic vs. healthy mice. In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related...
Nephron (2016) 134 (3): 167–171.
Published Online: 30 August 2016
...Heather M. Perry; Mark D. Okusa Kidney disease affects millions of people worldwide and it is now widely accepted that many pathological processes may persist after acute kidney injury that can cause the progression to CKD. Tubulointerstitial fibrosis manifests soon after injury and while many...
Nephron (2016) 132 (3): 238–243.
Published Online: 19 February 2016
...Mohammad A. Shafiee; Alexander G. Logan; Mitchell L. Halperin Background/Aims: As restful, non-interrupted sleep is essential for normal mental and physical functioning, the urine flow rate (U FR ) overnight remains low. Due to this reduced U FR , the kidneys produce a lower urine volume, which may...
Ruud R.G. Bueters, Annelies Jeronimus-Klaasen, Nuria Maicas, Sandrine Florquin, Lambertus P. van den Heuvel, Michiel F. Schreuder
Nephron (2016) 132 (2): 110–118.
Published Online: 26 January 2016
...Ruud R.G. Bueters; Annelies Jeronimus-Klaasen; Nuria Maicas; Sandrine Florquin; Lambertus P. van den Heuvel; Michiel F. Schreuder Background: Diuretics are administered to neonates to control fluid balance. We studied whether clinical doses affected kidney development and function and whether...
Stuart William Smith, Adam Paul Croft, Hannah Louise Morris, Amy Jane Naylor, David Leonard Huso, Clare Marie Isacke, Caroline Olivia Susan Savage, Christopher Dominic Buckley
Nephron (2016) 131 (4): 265–277.
Published Online: 04 December 2015
... is a transmembrane glycoprotein expressed by key effector cells within the stroma of fibrotic kidneys including pericytes, myofibroblasts and stromal fibroblasts. In human disease, increased expression of CD248 by stromal cells predicts progression to end-stage renal failure. We therefore, hypothesized...