..., we discuss the role of iron imbalance in mediating the pathogenic events during sepsis. Intracellular ferritin serves as a repository for iron and prevents iron-mediated injury and may limit the availability of iron to pathogens. Circulating levels of ferritin also increase during sepsis and often...

... regulated suggesting spatial pathogenic mechanisms in the kidney. Downregulation of cortical tubulointerstitium genes involved in iron metabolism was detected along with iron accumulation. Conclusion: This study demonstrates several regulated genes in pathways important for the pathogenesis of the NTN model...

...Sundararaman Swaminathan Background: Iron is critical for fundamental biologic functions such as cell division and mitochondrial electron transport. However, by the virtue of its ability to donate electrons, iron is probably the most effective oxidant in biologic systems. Summary: To avoid damage...

...Shinji Tanaka; Tetsuhiro Tanaka Iron deficiency is a major cause of hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) and is often observed in chronic kidney disease (CKD) patients with anemia. With iron supplementation, ESA doses can be decreased, resulting in lower treatment costs...

... an equivalent of 150 mg of elemental iron of either preparation, in a random fashion. After a baseline fasting serum iron level was obtained, the serum iron concentration was measured at 2 h in the control group and at 2 and 4h in the CAPD patients. One to 2 months later, all study subjects received...

... on chronic ambulatory peritoneal dialysis (CAPD), were treated intravenously with this preparation in a dose of 100 mg elemental iron twice monthly. There were five groups. Group 1:41 HD patients who were receiving erythropoietin (EPO) for at least 6 months prior to the addition of IV Fe. In this group, when...

... Amino-aciduria Enzymuria Proximal tubular dysfunction Iron 1 11 1991 12 12 2008 Original Paper Nephron 1992;62:18-21 Patricia C.K. Chana W.H. Chow» Sidney C.F. Tamb Ignatius K.P. Chenga M.K. Chan» Amino-Aciduria and Enzymuria in Patients with Artificial Heart Valves Department...

...Thomas O. Pitts; Galen L. Barbour Autopsy data on 24 chronic maintenance hemodialysis patients who had received varying doses of parenteral iron as the iron-dextran complex were reviewed for evidence of iron overload (hemosiderosis) and tissue fibrosis or organ dysfunction (hemochromatosis...

...Charles Beerenhout; Otto Bekers; Jeroen P. Kooman; Frank M. van der Sande; Karel M.L. Leunissen An adequate iron management is important in the treatment of anemia and in hemodialysis (HD) patients. Serum ferritin and transferrin saturation (TS) may be influenced by the presence of inflammation...

...Akihiko Kato; Mayumi Hamada; Takayuki Suzuki; Takanori Maruyama; Yukitaka Maruyama; Akira Hishida Aims: To conduct a 3-month prospective study to determine the optimal way for intravenous iron supplementation in hemodialysis (HD) patients with resistance to recombinant human erythropoietin (rHuEPO...