... in VC as an epigenetic regulator. Indoxyl sulfate (IS) is a protein-bound uremic toxin that has been proven as one of the major risk factors of cardiovascular disease in CKD. SET domain containing lysine methyltransferase 7/9 (SET7/9) is one of the important histone methyltransferases. Objectives...

...Junna Yamaguchi; Tetsuhiro Tanaka; Reiko Inagi AST-120 (kremezin; Kureha Chemical, Tokyo, Japan) is an oral spherical carbonaceous adsorbent, which was approved for clinical use in Japanese chronic kidney disease (CKD) patients in 1991. It adsorbs indole, the precursor of indoxyl sulfate...

... of chronic kidney disease and cardiovascular disease. This study is aimed at investigating whether indoxyl sulfate (IS) affects Mas receptor expression, cell proliferation and tissue factor expression in vascular smooth muscle cells, and if Ang-(1-7), an activator of Mas receptor, counteracts the IS-induced...

...Toshimitsu Niwa; Takashi Miyazaki; Saori Tsukushi; Kenji Maeda; Yoshiharu Tsubakihara; Akira Owada; Tatsuo Shiigai We identified and quantified indoxyl-β- D -glucuronide in uremic serum and urine to determine the metabolism of indoles including indoxyl sulfate in uremic patients. Serum levels...

...Toshimitsu Niwa; Tomoko Yazawa; Michihito Ise; Mikio Sugano; Tomio Kodama; Yasuo Uehara; Kenji Maeda Serum indoxyl sulfate, which is markedly accumulated in uremic patients, cannot be removed efficiently by hemodialysis due to its albumin binding. To determine if oral adsorbent (AST-120) can...

...Noriyoshi Kobayashi; Atsuko Maeda; Satoshi Horikoshi; Isao Shirato; Yasuhiko Tomino; Michihito Ise The aim of the present study was to determine if treatment with an oral adsorbent (AST-120, Kremezin ® ) might decrease the urinary albumin excretion and serum indoxyl sulfate (s-IS), and prevent...